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| 1 | A Direct Link between Abscisic Acid Sensing and the Chromatin-Remodeling ATPase BRAHMA via Core ABA Signaling Pathway ComDonents显示文摘对干旱的最佳的反应为植物幸存是批评的并且将在气候变化期间影响生物多样性和庄稼性能。有丝分裂地可继承的 epigenetic 或动态染色质状态变化在对干旱压力荷尔蒙 abscisic 酸(骆驼毛的织物) 的植物反应被含有。Arabidopsis SWI/SNF 改变染色质的 ATPase 梵天(BRM ) 由在萌芽期间阻止压力反应小径的早熟的激活调制反应到骆驼毛的织物。我们证明核心骆驼毛的织物发信号小径部件身体上与 BRM 交往并且 post-translationally 由 phosphorylation/dephosphorylation 修改 BRM。基因证据建议 SnRK2.2/2.3 kinases 下游的 BRM 行为,和生物化学的研究鉴别在在 SnRK2 的 BRM 的 C 终端区域的 phosphorylation 地点指向 evolutionarily 被保存的地点。最后, phosphomimetic BRM S1760D S1762D 异种显示骆驼毛的织物超敏性。优先的研究证明 BRM 当面在 ABA 小径住在目标 loci 并且刺激的缺席,但是当骆驼毛的织物不在时仅仅是活跃的。我们的数据建议 BRM 的 SnRK2 依赖的 phosphorylation 导致它的抑制,并且 BRM 的调停 PP2CA 的 dephosphorylation 恢复 BRM 的能力镇压骆驼毛的织物反应。这些调查结果点到存在一快速基于 phosphorylation 换到控制 BRM 活动;这个性质能潜在地被利用在植物改进干旱忍耐。 | Marta Peirats-Llobet Soon-Ki Han Miguel Gonzalez-Guzman Cheol Woong Jeong Lesia Rodriguez Borja Belda-Palazon Doris Wagner Pedro L. Rodriguez | 2016 | Molecular Plant2016，9，1： | 13 |
| 2 | Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery显示文摘According to the United States census bureau 20% of Americans will be older than 65 years in 2030 and half of them will need an operation- equating to about 36 million older surgical patients. Older adults are prone to complications during gastrointestinal cancer treatment and therefore may need to undergo special pretreatment assessments that incorporate frailty and sarcopenia assessments. A focused, structured literature review on Pub Med and Google Scholar was performed to identify primary research articles, review articles, as well as practice guidelines on frailty and sarcopenia among patients undergoing gastrointestinal surgery. The initial search identified 450 articles; after eliminating duplicates, reports that did not include surgical patients, case series, as well as case reports, 42 publications on the impact of frailty and/or sarcopenia on outcome of patients undergoing gastrointestinal surgery were included. Frailty is defined as a clinically recognizable state of increased vulnerability to physiologic stressors resulting from aging. Frailty is associated with a decline in physiologic reserve and function across multiple physiologic systems. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Unlike cachexia, which is typically associated with weight loss due to chemotherapy or a general malignancy-related cachexia syndrome, sarcopenia relates to muscle mass rather than simply weight. As such, while weight reflects nutritional status, sarcopenia- the loss of muscle mass- is a more accurate and quantitative global marker of frailty. While chronologic age is an important element in assessing a patient's peri-operative risk, physiologic age is a more important determinant of outcomes. Geriatric assessment tools are important components of the preoperative work-up and can help identify patients who suffer from frailty. Such data are important, as frailty and sarcopenia have repeatedly been demonstrated among the strongest predictors of both short- and longterm outcome following complicated surgical procedures such as esophageal, gastric, colorectal, and hepatopancreatico-biliary resections. | doris wagner mara mcadams demarco neda amini stefan buttner dorry segev faiz gani timothy m pawlik | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 8 |
| 3 | Sirolimus has a potential to influent viral recurrence in HCV positive liver transplant candidates显示文摘 | Doris Wagner Daniela Kniepeiss Silvia Schaffellner Estrella Jakoby Helmut Mueller Astrid Fahrleitner-Pammer Philipp Stiegler Karl-Heinz Tscheliessnigg Florian Iberer | 2010 | International Immunopharmacology2010，，8： | 1 |
| 4 | The MicroRNA-Regulated SBP-Box Transcription Factor SPL3 Is a Direct Upstream Activator of LEAFY , FRUITFULL , and APETALA1显示文摘 | Ayako Yamaguchi Miin-Feng Wu Li Yang Gang Wu R. Scott Poethig Doris Wagner | 2009 | Developmental Cell2009，，2： | 1 |
| 5 | H2A.Z contributes to trithorax activity at the AGAMOUS locus显示文摘Dear Editor,In multicellular eukaryotes,Polycomb repression heritably si-lences gene expression programs not needed or detrimental for a given developmental stage or tissue(Schuettengruber et al.,2017).During cell fate reprogramming,Polycomb silencing can be overcome by the combined activity of multiple Trithorax group(TrxG)proteins(Wu et al.,2012;Liang et al.,2015;Schuettengruber et al.,2017).TrxG proteins are genetically defined as suppressors of homeotic defects caused by loss of Polycomb function and have diverse enzymatic activities(Schuettengruber et al.,2017).We used a genetic enhancer screen to identify candidate TrxG proteins and uncovered TrxG activity for components of the SWR1 chromatin remodeling complex,which deposits the histone variant H2A.Z(Deal et al.,2007;March-Diaz et al.,2008). | Un-Sa Lee Tomasz Bieluszewski Jun Xiao Ayako Yamaguchi Doris Wagner | 2022 | Molecular Plant2022，15，2： | 0 |
| 6 | Mechanical upper bowel obstruction caused by a large trichobezoar in a young woman: A very unusual case report显示文摘BACKGROUND Bezoars usually compile human fibers and debris.A special form of bezoar in case of psychologically altered individuals is the trichobezoar.It consists of voluntarily swallowed hair bulks and is normally removed via gastroscopy.Trichobezoars leading to ileus have rarely been reported.CASE SUMMARY A 24-year-old female patient presented to the emergency room with abdominal pain,nausea,and vomiting for 3 d.Her previous medical and psychiatric history was unremarkable.Laboratory analysis showed iron deficiency anemia,leukocytosis,and elevated liver enzymes.An abdominal CT scan revealed a dense structure in the patients’stomach which turned out to be a huge trichobezoar completely obstructing the pylorus.The trichobezoar had to be removed surgi-cally.During her postoperative course,a subcutaneous seroma formed.After a single puncture,the rest of the recovery process was unremarkable,and the patient recovered fully.CONCLUSION A mechanical bowel obstruction is a potentially life-threatening event for every patient.In our case a young female was suffering from severe symptoms of an obstruction which might have resulted in serious harm without successful surgical management. | Magdalena Scherrer Peter Kornprat Robert Sucher Johanna Muehlsteiner Doris Wagner | 2024 | World Journal of Clinical Cases2024，12，4： | 0 |
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