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| 1 | Human thrombin for the treatment of gastric and ectopic varices显示文摘AIM:To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic varices.METHODS:Retrospective observational study in a Tertiary Referral Centre.Between January 1999-October 2005,we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic varices.Patient details including age,gender and aetiology of liver disease/segmental portal hypertension were documented.The thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection needle.All patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was recorded.Initial haemostasis rates,rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin therapy.The duration of follow up was also listed.The study was conducted according to the United Kingdom research ethics guidelines.RESULTS:Thirty-seven patients were included.33 patients(89%) had thrombin(250 U/mL) for gastric varices,2(5.4%) for duodenal varices,1 for rectal varices and 1 for gastric and rectal varices.(1) Gastric varices,an average of 15.2 mL of thrombin was used per patient.Re-bleeding occurred in 4 patients(10.8%),managed in 2 by a transjugular intrahepatic portosystemic shunt(TIPSS)(one unsuccessfully who died) and in other 2 by a distal splenorenal shunt;(2) Duodenal varices(or type 2 isolated gastric varices),an average of 12.5 mL was used per patient over 2-3 endoscopy sessions.Re-bleeding occurred in one patient,which was treated by TIPSS;and(3) Rectal varices,an average of 18.3 mL was used per patient over 3 endoscopy sessions.No re-bleeding occurred in this group.CONCLUSION:Human thrombin is a safe,easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices. | Norma C McAvoy John N Plevris Peter C Hayes | 2012 | World Journal of Gastroenterology2012，18，41： | 11 |
| 2 | Molecular and physiological characterization of the effects of auxin-enriched rootstock on grafting显示文摘Grafting is a highly useful technique,and its success largely depends on graft union formation.In this study,we found that root-specific expression of the auxin biosynthetic gene iaaM in tobacco,when used as rootstock,resulted in more rapid callus formation and faster graft healing.However,overexpression of the auxin-inactivating iaaL gene in rootstocks delayed graft healing.We observed increased endogenous auxin levels and auxin-responsive DR5::GUS expression in scions of WT/iaaM grafts compared with those found in WT/WT grafts,which suggested that auxin is transported upward from rootstock to scion tissues.A transcriptome analysis showed that auxin enhanced graft union formation through increases in the expression of genes involved in graft healing in both rootstock and scion tissues.We also observed that the ethylene biosynthetic gene ACS1 and the ethylene-responsive gene ERF5 were upregulated in both scions and rootstocks of the WT/iaaM grafts.Furthermore,exogenous applications of the ethylene precursor ACC to the junction of WT/WT grafts promoted graft union formation,whereas application of the ethylene biosynthesis inhibitor AVG delayed graft healing in WT/WT grafts,and the observed delay was less pronounced in the WT/iaaM grafts.These results demonstrated that elevated auxin levels in the iaaM rootstock in combination with the increased auxin levels in scions caused by upward transport/diffusion enhanced graft union formation and that ethylene was partially responsible for the effects of auxin on grafting.Our findings showed that grafting success can be enhanced by increasing the auxin levels in rootstocks using transgenic or gene-editing techniques. | Longmei Zhai Xiaomin Wang Dan Tang Qi Qi Huseyin Yer Xiangning Jiang Zhenhai Han Richard McAvoy Wei Li Yi Li | 2021 | Horticulture Research2021，8，1： | 3 |
| 3 | A randomised control trial of a self-management program for people with a chronic illness from Vietnamese, Chinese, Italian and Greek backgrounds显示文摘 | Hal Swerissen John Belfrage Amanda Weeks Lucinda Jordan Christine Walker John Furler Brian McAvoy Meredith Carter Chris Peterson | 2006 | Patient Education and Counseling2006，，1： | 2 |
| 4 | Base control for the tennesse eastman problem显示文摘 | MCAVOY T J YE N | 1994 | Computers Chem Eng1994，18，5： | 2 |
| 5 | Laminin-binding integrins in rat lens morpho- genesis and their regulation during fibre differentiation显示文摘 | WedereU ED Brown H O' Connor M Chamberlain CG McAvoy JW de Iongh RU | 2005 | Exp Eye Res2005，81，3： | 1 |
| 6 | Dynamics of pH in Controlled Stirred Tank reactor显示文摘 | McAvoy T J Hsu E Lowenthal S | 1972 | Ind Eng Chem Process Des1972，11，1： | 1 |
| 7 | Fate of linear aylkybenzene sulfonates in the environment 显示文摘 | McAvoy D C Eckhoff W S Rapaport R A | 1993 | Toxic Chem1993，12，： | 1 |
| 8 | Batch tracking via nonlinear principal component analysis显示文摘 | McAvoy T J | 1996 | AIChE1996，42，8： | 1 |
| 9 | 显示文摘 | Klerk J D Weinert R W Mcavoy B R | 1979 | IEEE Transations on Sonics and Ultrasonics1979，26，： | 1 |
| 10 | IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages 显示文摘 | Richardson NA Chamberlain CG McAvoy JW | 1993 | Invest Ophthalmol Vis Sci1993，34，20： | 1 |
| 11 | Batch-to-batch optimization using neural network models显示文摘 | Dong D McAvoy T Zafiriou E | 1996 | Industrial & Engineering Chemistry Research1996，35，： | 1 |
| 12 | Aluminum precipitation and dissolution rates in spodosol Bs horizons in the northeastern USA 显示文摘 | Dahlgren R A Driseoll C T McAvoy D C | 1989 | Soil Sci Soc Am J1989，53，： | 1 |
| 13 | Contemplative Stance for Chemical Process Control显示文摘 | MCAVOY T J | 1992 | Automatica1992，28，2： | 1 |
| 14 | Inhibition of FGF-induced alpha A-crystallin promoter activity in lens epithelial explants by TGF beta显示文摘 | Ueda Y Chambertain CG Satoh K McAvoy JW | 2000 | Invest Ophthalmol Vis Sci2000，41，7： | 1 |
| 15 | Optimizing neural net based predictive control显示文摘 | Bhat N McAvoy T J | 1990 | Proc American Control Cont1990，3，： | 1 |
| 16 | Growth factors involved in aqueous humour-induced lens cell proliferation显示文摘 | IYENGAR L PATKUNANATHAN B MCAVOY JW | 2009 | Growth Factors2009，27，1： | 1 |
| 17 | Islation enhanced principal component analysis显示文摘 | Gertler J Li W Huang Y and McAvoy T | 1999 | AIChE Journal1999，45，： | 1 |
| 18 | Development of a mathematical model foe physical disintegration of flushable con- sumer products in wastewater systems显示文摘 | Karadagli F Mcavoy D C Rittmann B E | 2009 | Water Environ Res2009，81，5： | 1 |
| 19 | Toxicity and bioaccumulation of biosolids-bome triclocarban (TCC) in terrestrial organisms显示文摘 | Snyder E H O'Connor G A McAvoy D C | 2011 | Chemosphere2011，82，3： | 1 |
| 20 | Use of neural networks for sensor failure detection in a control system显示文摘 | Zafiriou E McAvoy T J | 1990 | IEEE Control System Magazine1990，10，3： | 1 |
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