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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Influence of Motor Drive Parameters on the Robust Stability of Electric Power Steering Systems显示文摘 | Roy McCann L R Pujara J Lieh | 1998 | IEEE O-7803-4398-0/9981998，，： | 2 |
| 3 | Collecting Electrospun Nanofibers with Patterned Electrodes 显示文摘 | Li D Ouyang G McCann J T | 2005 | Nano Letters2005，5，5： | 1 |
| 4 | Retinex at 40显示文摘 | McCann J J | 2004 | Journal of Electronic Imaging2004，13，1： | 1 |
| 5 | Methods for detecting carcino gens and mutagens with the Salmonella/mammalian microsome mutagenicity test显示文摘 | Ames BN McCann J Yamasaki E | 1975 | Murat Res1975，31，6： | 1 |
| 6 | Do postoperative platelet - rich plasma injections accelerate early tendon healing and function- al recovery after arthroscopic supraspinatus repair? A randomized controlled trial显示文摘 | Wang A Mccann P Colliver J | 2015 | Am J Sports Med2015，43，6： | 1 |
| 7 | Electrospinning: a simpleand versatile technique for producing ceramic nanofibers and nanotubes 显示文摘 | Li D McCann J T Xia Y N | 2006 | Journal of the American Ceramic Society2006，89，6： | 1 |
| 8 | Lightness and Retinex theory显示文摘 | Land E McCann J J | 1971 | Journal of the Optical Society of America1971，61，1： | 1 |
| 9 | Use of electrospinning to directly fabricate hollow nanofibers with funetionalized inner and outer surfaces 显示文摘 | Li D McCann J T Xia Y | 2005 | Small2005，1，： | 1 |
| 10 | Quantitative Studies in Retinex Theory:A Comparison between Theoretical Predictions and Observer Responses to the 'Color Mondrian' Experiments显示文摘 | McCann J J McKee S P Taylor T H | 1978 | Vision Research1978，16，5： | 1 |
| 11 | A pectate lyase from Zinnia elegans is auxin inducible显示文摘 | Domingo C Roberts K Stacey N J Connerton I RuoAz-TeraAn F McCann M C | 1998 | Plant J1998，13，： | 1 |
| 12 | Prevalence of asymmetric exophthalmos in Graves orbitopathy显示文摘 | SOROUDI A E GOLDBERG R A MCCANN J D | 2004 | Ophthal Plast Reconstr Surg2004，20，3： | 1 |
| 13 | The physio- logic effects of isoflurane anesthesia in neonatal mice 显示文摘 | Loepke A W McCann J C Kurth C D | 2006 | Anesth Analg2006，102，1： | 1 |
| 14 | Etnerging options for the management of fecal incontinence in hospitalized patients显示文摘 | Wishin J Gallagher TJ McCann E | 2008 | J wound 0stomy Continence Nurs2008，35，1： | 1 |
| 15 | Isolation and characterisation of antibacterial peptides derived from the f ( 164 -207) region of bovineαs2 -casein 显示文摘 | McCann K B Shiell B J Michalski W P | 2005 | Int Dairy J2005，15，2： | 1 |
| 16 | Transferrin: structure, function and potential therapeutic actions 显示文摘 | Gomme P T McCann K B Bertolini J | 2005 | Drug Discov- ery Today2005，10，4： | 1 |
| 17 | The bispectral index and explicit recall during the intraoperative wake-up test for scoliosis surgery显示文摘 | McCann ME Brustowicz RM Bacsik J | 2002 | Anesth Analg2002，94，6： | 1 |
| 18 | Evaluation of expanded bed adsorption chromatography for extraction of prothrombin complex from cohn supernataut I显示文摘 | McCann KB Gomme PT Wu J | 2008 | Biological2008，36，4： | 1 |
| 19 | Schizophrenia and tobacco smoking:a replication study in another US psychiatric hospital显示文摘 | de Leon J Tracy J McCann E | 2002 | Schizophr Res2002，56，12： | 1 |
| 20 | Unique equilibria and substitution effects in a stochas- tic model of the marriage market显示文摘 | DECKER C LIEB E H MCCANN R J | 2013 | Journal of Eco- nomic Theory2013，148，2： | 1 |
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