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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Effects of residual and reapplied biosolids on performance and mineral status of grazing beef steers显示文摘 | Tiffany M E Me Dowell L R O'connor G A etal | 2002 | Journal of Animal Science2002，80，： | 1 |
| 4 | Chemical aspects of clustered DNA damage induction by ionising radiation显示文摘 | Lomax ME Gulston MK and O'Neill P | 2002 | Radiat Prot Dosim2002，99，14： | 1 |
| 5 | Phase Ⅲ trial comparing supportive care alone with supportive care with oral to-potecan in patients with relapsed small cell lung cancer 显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，： | 1 |
| 6 | Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindoprilAndapamide combination in hypertensive patient: a comparison with atenolol显示文摘 | Asmar RG Londan GM O Rourke ME REASON Prelect Coordinators and Investigators | 2001 | Hypertension2001，38，11： | 1 |
| 7 | Alcohol consumption in the severely obese:relationship with the metabolic syndrome显示文摘 | Dixon JB Dixon ME O'Brien PE | 2002 | Obe Res2002，10，： | 1 |
| 8 | Phase Ⅲ trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，34： | 1 |
| 9 | Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choricareinoma cells:selective regulation via estrogen receptors alphaand beta 显示文摘 | O'Neff JS Burow ME Green AE | 2009 | Mol Cell Endocrinol2009，176，12： | 1 |
| 10 | Complex distal hu- meral fractures: internal fixation with a principle based parallel plate technique 显示文摘 | Sanchez-Sotelo J Torchia ME O' Driscoll SW | 2007 | J Bone Joint Surg (Am)2007，89，： | 1 |
| 11 | Comparative metabonomics of differential hydrazine toxicity in the rat and mouse显示文摘 | Bollard ME Keun HC Beckonert O | 2005 | Toxicol Appl Pharmcol2005，204，2： | 1 |
| 12 | Molecular imprinting in sol - gel materials: recent developments and applica- tions显示文摘 | Dl'az-Garcl'a ME Lal'n - o RB | 2005 | Microehim Acta2005，，12： | 1 |
| 13 | Relationship between aortic stiffening and microvascular disease in brain and kidney:cause and logic of therapy显示文摘 | O'Rourke MF Safar ME | | 0，，： | 1 |
| 14 | Complex distal humeral fractures:internal fixation with a principle-based parallelplate technique显示文摘 | Sanchez-Sotelo J Torchia ME O'Driscoll SW | | 0，，05： | 1 |
| 15 | Putting humpty dumpty together again:the importance of integrating cognitive and emotional interventions显示文摘 | Mateer CA Sira CS O'Connell ME | | 0，，01： | 1 |
| 16 | Structural de- terminants of phosphoinositide 3-kinase inhibition by wort- mannin, LY294002, quereetin, myricetin, and staurospo- rine显示文摘 | Walker EH Pacold ME Perisic O | 2000 | Mol Cell2000，6，4： | 1 |
| 17 | US of gastrointestinal tract abnormalities with CT correlation 显示文摘 | O'Malley ME Wilson SR | 2003 | Radiographics2003，23，1： | 1 |
| 18 | Phase Ⅲ trial comparing supportive carealone with supportive carewith oral topotecan in patients with relapsed small-cell lung cancer显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，34： | 1 |
| 19 | Complex distal humeral fractures: internal fixation with a principle-based parallel-plate technique 显示文摘 | Sanchez SJ Torchia ME O' Driscoll SW | 2007 | J Bone Joint Surg Am2007，89，： | 1 |
| 20 | Phase Ⅲ trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，34： | 1 |
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