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| 1 | Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice显示文摘AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice.METHODS: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation. | Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero | 2006 | World Journal of Gastroenterology2006，12，40： | 9 |
| 2 | Imaging of the temporomandibular joint: An update显示文摘Imaging of the temporomandibular joint(TMJ) is continuously evolving with advancement of imaging technologies. Many different imaging modalities are currently used to evaluate the TMJ. Magnetic resonance imaging is commonly used for evaluation of the TMJ due to its superior contrast resolution and its ability to acquire dynamic imaging for demonstration of the functionality of the joint. Computed tomography and ultrasound imaging have specific indication in imaging of the TMJ. This article focuses on state of the art imaging of the temporomandibular joint. Relevant normal anatomy and biomechanics of movement of the TMJ are discussed for better understanding of many TMJ pathologies. Imaging of internal derangements is discussed in detail. Different arthropathies and commontumors are also discussed in this article. | Asim K Bag Santhosh Gaddikeri Aparna Singhal Simms Hardin Benson D Tran Josue A Medina Joel K Curé | 2014 | World Journal of Radiology2014，6，8： | 5 |
| 3 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 4 | Measuring and modelling the soil shrinkage characteristic curve显示文摘 | W.M. Cornelis J. Corluy H. Medina J. Díaz R. Hartmann M. Van Meirvenne M.E. Ruiz | 2006 | Geoderma2006，，1： | 2 |
| 5 | Laparoscopically monitored colonoscopic polypectomy: an established form of endoluminal therapy for colorectal polyps显示文摘 | Franklin ME Jr Leyva Alvizo A Abrego Medina D | 2007 | Surg Endosc2007，21，9： | 1 |
| 6 | Antineoplastic effects of partially HLA-matched irradiated blood mononuclear cells in patients with renal cell carcinoma 显示文摘 | Strair RK Schaar D Medina D | 2003 | J Clin Oncol2003，21，20： | 1 |
| 7 | Carcinoma-associatedfibroblast-like differention of human mesenchymal stem cells显示文摘 | Mishra P J Humeniuk R Medina D J | 2008 | Cancer Research2008，68，11： | 1 |
| 8 | Dental implant failure rates and associated risk factors显示文摘 | Moy PK Medina D Shetty V | | 0，，： | 1 |
| 9 | Hedgehog signalling as a target in cancer stem cells显示文摘 | Medina V Calvo MB Díaz-Prado S | 2009 | Clin Transl Oncol2009，11，4： | 1 |
| 10 | The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer显示文摘 | Medina P P Castillo S D Blanco S | 2009 | Hum Mol Genet2009，18，7： | 1 |
| 11 | Spent mushroom substrates as component of growing media for germination and growth of horticultural plants 显示文摘 | Medina E Paredes C Perez-Murcia M D | 2009 | Bioresource Technology2009，，100： | 1 |
| 12 | Chemical characterization of Opuntia dillenii and Opuntia ficus indica fruits显示文摘 | E.M. Díaz Medina E.M. Rodríguez Rodríguez C. Díaz Romero | 2006 | Food Chemistry2006，，1： | 1 |
| 13 | In vitro cultured primary roots derived from stem segments of cassava(Manihot esculenta)can behave like storage organs显示文摘 | Medina R D Faloci M M Conzalez A M et d | 2007 | Annals of Botany2007，99，： | 1 |
| 14 | The development of voidage and capillary size within extruded plastic films显示文摘 | MEDINA D I HALLMARK B LORD T D | 2008 | Journal of Materials Science2008，43，15： | 1 |
| 15 | Effects of combinsfion estrogen: cyclophosphamide treatment on the growth of the MXT transplantable mammary tumor in the mouse显示文摘 | Medina D Clark JH | 1983 | Cancer Res1983，43，7： | 1 |
| 16 | Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus x gene 显示文摘 | Slagle B L Lee T H Medina D | 1996 | Mol Carcinog1996，15，： | 1 |
| 17 | Information sharing with collabora- tive convergence: the case for interaction 显示文摘 | SUTHERS D MEDINA R | 2007 | Computer Sup- port for Collaborative Learning2007，，9： | 1 |
| 18 | Careinogen indueibility in vivo and down regulation of DMBT1 during breast careinogenesi显示文摘 | Mollenhauer J Helmke B Medina D | 2004 | Genes Chromosomes Cancer2004，39，3： | 1 |
| 19 | A visual reporter system for virus-induced gene silencing in tomato fruit based on anthocyanin accumulation显示文摘 | Orzaez D Medina A Torre S | | 0，，03： | 1 |
| 20 | Spentmushroom substrates as component of growing media for germina-tion and growth of horticultural plants显示文摘 | MEDINA E PAREDES C PREZ-MURCIA M D | 2009 | Bioresourse Technolo-gy2009，100，： | 1 |
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