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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Spent mushroom substrates as component of growing media for germination and growth of horticultural plants显示文摘 | E. Medina C. Paredes M.D. Pérez-Murcia M.A. Bustamante R. Moral | 2009 | Bioresource Technology2009，，18： | 2 |
| 3 | Polymorphisms in the endothelial protein C receptor gene and thrombophilia显示文摘 | Medina P Navarro S Estelles A | 2007 | Thromb Haemost2007，98，： | 1 |
| 4 | Carcinoma-associatedfibroblast-like differention of human mesenchymal stem cells显示文摘 | Mishra P J Humeniuk R Medina D J | 2008 | Cancer Research2008，68，11： | 1 |
| 5 | OncomiR addiction inan in vivo model of microRNA-21-induced pre-B-cell lymphoma显示文摘 | MEDINA P P NOLDE M SLACK F J | 2010 | Nature2010，467，： | 1 |
| 6 | Senescence-associated genes induced during compatible viral inter- actions with grapevine and Arabidopsis显示文摘 | ESPINOZA C MEDINA C SOMERVILLE S ARCE-JOHNSON P | 2007 | Journal of Experimental Botany2007，58，12： | 1 |
| 7 | The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer显示文摘 | Medina P P Castillo S D Blanco S | 2009 | Hum Mol Genet2009，18，7： | 1 |
| 8 | Regression of murine lung tumors by the let-7 microRNA 显示文摘 | Trang P Medina PP Wiggins JF | 2010 | Oncogene2010，29，11： | 1 |
| 9 | Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma显示文摘 | Medina E Arioli I | 1998 | Blood1998，16，： | 1 |
| 10 | Complications of three sacrospinous ligament fixation tenchiques显示文摘 | Pollak J Takacs P Medina C | 2007 | Int J Gynecol Obstet2007，99，1： | 1 |
| 11 | Decrease in serum adiponectin levels associated with visceral fat accu- mulation independent of pubertal stage in children and adolescents 显示文摘 | Medina - Bravo P Meza - Santibdfiez R Rosas - Ferndndez P | 2011 | Arch Med Res2011，42，2： | 1 |
| 12 | Biocatalysis : towards ever greener biodiesel production 显示文摘 | ROBLES - MEDINA A GONZ:LEZ - MORENO P A ESTEBAN - CERDAN L | 2009 | Biotechnol Adv2009，27，4： | 1 |
| 13 | 查看详情显示文摘 | Alejandre A Medina F Salagre P Fabregat A.and Sueiras J.E | | 0，，： | 1 |
| 14 | Analysis of water transport in a high pressure PEM electrolyzer显示文摘 | MEDINA P SANTARALLI M | 2010 | International Journal of Hydrogen Energy2010，35，11： | 1 |
| 15 | Platelet Aggregation-Induced by Caco-2 Cells:Regulation by Matrix Metalloproteinase-2 and Adenosine Diphosphate显示文摘 | JURASZ P SANTOS-MARTINEZ M J | 2006 | J Pharmacol Exp Ther2006，317，： | 1 |
| 16 | Platelet aggregation-induced by caco-2 cells:regulation by matrix metalloproteinase-2 and adenosine diphosphate显示文摘 | Medina C Jurasz P Santos-Martinez MJ | 2006 | J Pharmacol Exp Ther2006，317，2： | 1 |
| 17 | Synthesis and assembly of hepatits B virus surface antigen particles in yeast显示文摘 | VALENZUELA P MEDINA A RUTTER W J | 1982 | Nature1982，298，： | 1 |
| 18 | Characterization of the Insulation and Leakage Currents of PV Generators: Relevance for Human Safety显示文摘 | HERNCNDEZ J VIDAL P MEDINA A | 2010 | Renewable Energy2010，35，3： | 1 |
| 19 | Qual- ity of acute myocardial infarction care and outcomes in 33,997 patients aged 80 years or older: Findings from get with the guidelines-coronary artery disease显示文摘 | MEDINA H M CANNON C P ZHAO X | 2011 | Am Heart J2011，162，： | 1 |
| 20 | Global lithium resources : relative importanceof pegmatite,brine and other deposits 显示文摘 | Stephen E Kealer Paul W Gruber Pablo A Medina Gregory A Keoleian Mark P Everson Timothy J Wall-ington | 2012 | Ore GeologyReviews2012，48，： | 1 |
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