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| 1 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 2 | Capsule endoscopy:Current practice and future directions显示文摘Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications,diagnostic yields and safety profile has been presented.Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel.Most commonly,small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease(CD)(in patients with or without a prior history of CD).Typically,CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis.Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures(such as patients known to have CD or presenting with obstructive symptoms)to reduce the risk of capsule retention.CE also has a role in patients with coeliac disease,suspected small bowel tumours and other small bowel disorders.Since the advent of small bowel CE,dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders.Oesophageal CE may be used to diagnose oesophagitis,Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability.Colon CE provides an alternative to conventional colonoscopy for symptomatic patients,while a possible role in colorectal cancer screening is a fascinating prospect.Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy. | Melissa F Hale Reena Sidhu Mark E McAlindon | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 3 | Microbiome as mediator: Do systemic infections start in the gut?显示文摘The intestinal microbiome is emerging as a crucial mediator between external insults and systemic infections. New research suggests that our intestinal microorganisms contribute to critical illness and the development of non-gastrointestinal infectious diseases.Common pathways include a loss of fecal intestinal bacterial diversity and a disproportionate increase in toxogenic bacterial species. Therapeutic interventions targeting the microbiome- primarily probiotics- have yielded limited results to date. However, knowledge in this area is rapidly expanding and microbiome-based therapy such as short-chain fatty acids may eventually become a standard strategy for preventing systemic infections in the context of critical illness. | Melissa Latorre Suneeta Krishnareddy Daniel E Freedberg | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 4 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 5 | Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间表示一连串的激活受体在早怀孕期间调整胎盘的免疫和开发。我们在在 dNK 和 trophoblast 房间之间的怀孕期和相互作用的第一和第二个三个月期间调查了人的 dNK 房间的功能的特性。尽管 CD56 + 在全部的 CD45 + 白血球之中的 CD16 − dNK 没在这个句号,激活的受体的表示, NKp80 和 NKG2D 上变化,极大地 upregulated。我们与第二三个月蜕膜比较在第一个三个月在最近观察了 extravillous trophoblast 房间的一个显著地更高的数字到 dNK 房间。当 co 有教养时,由第一个三个月 dNK 房间的 NKG2D 表示与 HTR-8 trophoblast 房间线被减少。在第二个三个月, dNK 激活的功能的标记,即, angiogenic 因素生产(例如,脉管的 endothelial 生长因素, interleukin-8, interferon-gamma ) ,尽管有 NKp80 或 NKG2D 表面表示的增加的仍然是的马厩。而且, dNK 房间的 degranulation 能力由 CD107a 估计了在第二个三个月被减少。我们建议在第一个三个月, trophoblast-dNK 相互作用与压制的激活的显型产生 dNK 房间的一张人口。在第二个三个月, trophoblast-dNK 相互作用的损失导致了 dNK 房间功能的抑制,尽管他们的激活的受体表示被增加。我们推测在怀孕期间,二机制操作调制激活受体的 dNK 房间 activation:suppression,这由在第二个三个月联合的 receptor-ligand 的 trophoblasts 和解开在第一个三个月铺平。 | Jianhong Zhang Caroline E Dunk Melissa Kwan Rebecca L Jones Lynda K Harris Sarah Keating Stephen J Lye | 2017 | Cellular & Molecular Immunology2017，14，2： | 4 |
| 6 | Free fatty acid-iduced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signaling cascade显示文摘 | Griffin Melissa J | 1999 | Diabetes1999，48，6： | 1 |
| 7 | The extent of lymph node dissection for gastric caneer: a critical appraisal显示文摘 | De Bree E Charalampakis V Melissas J | 2010 | J Surg Oncol2010，102，6： | 1 |
| 8 | Cysts of the adrenal gland: diagnosis and management 显示文摘 | DE BREE E SCHORETSANITIS G MELISSAS J | 1998 | IntUrol Nephrol1998，，30： | 1 |
| 9 | Candidasepecific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasis 显示文摘 | Janet E Leigh Melissa Barousse Rolf K | 2001 | The Journal of Infectious Diseases2001，15，： | 1 |
| 10 | Crow, Smokescreens and State Respconsibility:Using Human Rights Strategies to Promote Global Tobacco 显示文摘 | CONTROL MELISSA E | 2004 | Yale International Law Review2004，29，1： | 1 |
| 11 | Polyacrylam-ide added as a nitrogen source stimulates methanogenesisin consortia form various wastewaters显示文摘 | Melissa E H Michael D M Phillip M F | 2005 | Water Re-search2005，39，14： | 1 |
| 12 | The mechanism of action of multidrug-resistance-linked P-glycoprotein 显示文摘 | ZUBEN E S MELISSA M S MARIANNA M | 2001 | J Bioenerg Biomembr2001，33，6： | 1 |
| 13 | Iron- deficiency anemia (IDA) in infancy and mother-infant interaction during feeding显示文摘 | RINAT A S MELISSA K E SANDRA W J | 2010 | Dev Behav Pediatr2010，31，4： | 1 |
| 14 | Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress 显示文摘 | Melissa H Nicolas A Roberta E | 2012 | Front Pharmacol2012，3，128： | 1 |
| 15 | Natural products inhibiting Candida albicans Secreted aspartic proteases from Lycopodiumcernuum显示文摘 | Zhang Z Z Hala N E Melissa R J etal | 2002 | J Nat Prod2002，65，7： | 1 |
| 16 | Simultaneous detection of marine fish pathogens by using multiplex PCR and a DNA microarray显示文摘 | Santiago F G Melissa J K Michael E N | 2004 | Clinical Microbiology2004，42，4： | 1 |
| 17 | Enzymeatre synthesis of medium chain mono-glycerides in a solvent-free system显示文摘 | MARTA A P L MELISSA E D A | 2002 | Applied Biochemistry and Biotechnology2002，98，： | 1 |
| 18 | Polyacrylamide added as a nitrogen source stimulates methanogenesis in consortia from various wastewaters显示文摘 | Melissa E H Michael D M Phillip M F | 2005 | Water Research2005，39，14： | 1 |
| 19 | Attentional task aptitude and performance anxiety显示文摘 | Hopko Derek R Hunt Melissa K Armento Maria E A | 2005 | International Journal of Stress Management2005，12，4： | 1 |
| 20 | Stat3 as an Oncogene显示文摘 | Jacqueline F Bromberg Melissa H Wrzeszczynska Geeta Devgan Yanxiang Zhao Richard G Pestell Chris Albanese James E Darnell | 1999 | Cell1999，，3： | 1 |
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