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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间表示一连串的激活受体在早怀孕期间调整胎盘的免疫和开发。我们在在 dNK 和 trophoblast 房间之间的怀孕期和相互作用的第一和第二个三个月期间调查了人的 dNK 房间的功能的特性。尽管 CD56 + 在全部的 CD45 + 白血球之中的 CD16 − dNK 没在这个句号,激活的受体的表示, NKp80 和 NKG2D 上变化,极大地 upregulated。我们与第二三个月蜕膜比较在第一个三个月在最近观察了 extravillous trophoblast 房间的一个显著地更高的数字到 dNK 房间。当 co 有教养时,由第一个三个月 dNK 房间的 NKG2D 表示与 HTR-8 trophoblast 房间线被减少。在第二个三个月, dNK 激活的功能的标记,即, angiogenic 因素生产(例如,脉管的 endothelial 生长因素, interleukin-8, interferon-gamma ) ,尽管有 NKp80 或 NKG2D 表面表示的增加的仍然是的马厩。而且, dNK 房间的 degranulation 能力由 CD107a 估计了在第二个三个月被减少。我们建议在第一个三个月, trophoblast-dNK 相互作用与压制的激活的显型产生 dNK 房间的一张人口。在第二个三个月, trophoblast-dNK 相互作用的损失导致了 dNK 房间功能的抑制,尽管他们的激活的受体表示被增加。我们推测在怀孕期间,二机制操作调制激活受体的 dNK 房间 activation:suppression,这由在第二个三个月联合的 receptor-ligand 的 trophoblasts 和解开在第一个三个月铺平。 | Jianhong Zhang Caroline E Dunk Melissa Kwan Rebecca L Jones Lynda K Harris Sarah Keating Stephen J Lye | 2017 | Cellular & Molecular Immunology2017，14，2： | 4 |
| 3 | Candidasepecific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasis 显示文摘 | Janet E Leigh Melissa Barousse Rolf K | 2001 | The Journal of Infectious Diseases2001，15，： | 1 |
| 4 | Iron- deficiency anemia (IDA) in infancy and mother-infant interaction during feeding显示文摘 | RINAT A S MELISSA K E SANDRA W J | 2010 | Dev Behav Pediatr2010，31，4： | 1 |
| 5 | Simultaneous detection of marine fish pathogens by using multiplex PCR and a DNA microarray显示文摘 | Santiago F G Melissa J K Michael E N | 2004 | Clinical Microbiology2004，42，4： | 1 |
| 6 | Attentional task aptitude and performance anxiety显示文摘 | Hopko Derek R Hunt Melissa K Armento Maria E A | 2005 | International Journal of Stress Management2005，12，4： | 1 |
| 7 | The role of estrogen receptor and 13 in regulating vascular smooth muscle cell prolif eration is based on sex 显示文摘 | Melissa E Hogg M D Ashley K Vavra M D Monisha N Banerjee 13 S | 2011 | Journal of Surgical Re- search2011，9，21： | 1 |
| 8 | Cognitive impairment:an increasingl important complication of type 2 diabetes显示文摘 | Jane S Mara K Melissa E | 2008 | Am J Epidemiol2008，168，10： | 1 |
| 9 | Social participation, flow and situational involvement in recreational physical activity 显示文摘 | Melissa D D Andrew T K Mark E H | 2009 | Journal of Leisure Research2009，41，1： | 1 |
| 10 | Identification of the drive constitutive renal COX-2 ex- pression: implications for novel COX-2-targetted therapies that spare the cardiovascular system显示文摘 | Nicholas K Melissa C E molecular pathways that iana G V | 2014 | The FASEB Journal2014，28，1： | 1 |
| 11 | Chemical shift mapping of shikirnate-3-phosphate bingding to the isolated N-terminal domain of 5-enolpyruvylshikimate-3-phosphate synthase 显示文摘 | Melissa E S John K Y Gregory L H | 2001 | FEBS Letters2001，499，： | 1 |
| 12 | The theory building from cases: Opportunities and challenges显示文摘 | Eisenhardt K M Melissa G E | 2007 | Academy of Mana- gement Journal2007，50，1： | 1 |
| 13 | Oral glucose tolerance test minimal model indexes of β-cell function and insulin sensitivity 显示文摘 | Breda E Melissa K C Toffolo G | 2001 | Diabetes2001，50，： | 1 |
| 14 | Simultaneous detection of marine fish pathogens by using multiplex PCR and a DNA microarray显示文摘 | Santiago F G Melissa J K Michael E N | 2004 | Clinical Microbiology2004，42，4： | 1 |
| 15 | Stimulatory effects of selected PAHson testosterone production in goldfish and rainbow trout and possible mechanisms of action 显示文摘 | MELISSA E GLEN J VAN D K | 2001 | Coparative Biochemistry and Physiology2001，130，： | 1 |
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