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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 3 | Feeding cessation effects of chlorantraniliprole,a new anthranilic diamide insecticide,in comparison with several insecticides in distinct chemical classes and mode-of-action groups显示文摘 | GREG T H MELISSA Z PAULA G M | 2009 | Pest Manage Sci2009，65，： | 1 |
| 4 | Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trial in humans显示文摘 | ZHOU X G MELISSA K M SHAW W | 2004 | J Nutr2004，134，： | 1 |
| 5 | Parathyroid careinonla: clinical presentation and management 显示文摘 | Schoretsanitis G Daskalakis M Melissas J | 2009 | Am J Otolaryngol2009，30，4： | 1 |
| 6 | Peripherally Inserted Central Venous Catheter-associated Thrombosis: Retrospective Analysis of Clinical Risk Factors in Adult Patients显示文摘 | King Melissa M Rasnake Mark S Rodriguez Rechell G | 2006 | Southern Medical Journal2006，99，10： | 1 |
| 7 | Gender differences in students' experiences interests and attitudes toward science and scientists显示文摘 | JONES M G ANN H MELISSA J R | 2000 | Science Education2000，84，： | 1 |
| 8 | Vimentin induces changes in censhape, motility, and adhesion during the epithe- lial to mesenchymal transition 显示文摘 | MELISSA G M KOMA S I GOLDMAN R D | 2010 | FASEB J2010，24，： | 1 |
| 9 | Modeling short-term variability of semivolatile organic chemicals in air at a local scale: An integrated modeling approach显示文摘 | Melissa M Davide G Antonio D et a1 | 2011 | Environmental Pollution2011，159，： | 1 |
| 10 | Predicating pressure gradients in heavy oil-water pipelines 显示文摘 | Melissa J M Randall G G Clifton A S | 2000 | The Canadian Journal of Chemical Engineering2000，8，8： | 1 |
| 11 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 12 | The role of UbiX in Escherichia coli coenzyme Q biosynthesis 显示文摘 | Melissa G Kyle R H Beth N M | 2007 | Archives of Biochemistry and Biophysics2007，467，2： | 1 |
| 13 | Rate of hepatitis B virus infection in preganant women determined by a monoclonal hepatitis B surface antigen immunoassay 显示文摘 | Melissa G Gotstein Aide P M | 2002 | J Clin Microbiol2002，40，9： | 1 |
| 14 | Feeding Cessation Effects of Chloran- traniliprole, a New Anthranilic Diamide Insecticide, in Comparison with Several Insecticides in Distinct Chemical Classes and Mode-of-achnn Groups 显示文摘 | Greg T H Melissa Z Paula G M | 2009 | Pest Manag Sci2009，65，9： | 1 |
| 15 | The health benefits of dietary fiber:Beyond the usual suspects of type 2 diabetes mellitus,cardiovascular disease and colon cancer显示文摘 | Melissa M K Michael J M Gregory G F | | 0，，08： | 1 |
| 16 | Assessing the level of healthcare information technology adoption in the United States: a snapshot显示文摘 | Eric G Poon Ashish K Jha Melissa Christino Mdissa M Honour etc | 2006 | BMC Medical Informaties & Decision Making2006，，6： | 1 |
| 17 | Attenuation of glycemic responses by oatβ-glucan solutions and viscoelastic gels is dependent on molecular weight distribution显示文摘 | Melissa G Y Kwong Thomas M S Wolever Yolanda Brummer | 2013 | Food and Function2013，4，3： | 1 |
| 18 | Parathyroidcarcinoma:clinical presentation and management 显示文摘 | Schoretsanitis G Daskalakis M Melissas J | 2009 | Am JOtolaryngol2009，30，4： | 1 |
| 19 | VirB12 is a serological marker of Brucella infection in experimental and natural hosts显示文摘 | Hortensia G R Andreas B D H Melissa K M | 2008 | Clin Vaccine Immunol2008，，2： | 1 |
| 20 | Ab initio and density functional theory studies for the explanation of the antioxidant activity of certain phenolic acids显示文摘 | Bakalbassis E G Chatzopoulou A Melissas V S Tsimidou M Tsolaki M Vafiadis A | 2001 | Lipids2001，36，： | 1 |
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