|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Semistructured interviewing in primary care research:a balance of relationship and rigour显示文摘Semistructured in-depth interviews are commonly used in qualitative research and are the most frequent qualitative data source in health services research.This method typically consists of a dialogue between researcher and participant,guided by a flexible interview protocol and supplemented by follow-up questions,probes and comments.The method allows the researcher to collect open-ended data,to explore participant thoughts,feelings and beliefs about a particular topic and to delve deeply into personal and sometimes sensitive issues.The purpose of this article was to identify and describe the essential skills to designing and conducting semistructured interviews in family medicine and primary care research settings.We reviewed the literature on semistructured interviewing to identify key skills and components for using this method in family medicine and primary care research settings.Overall,semistructured interviewing requires both a relational focus and practice in the skills of facilitation.Skills include:(1)determining the purpose and scope of the study;(2)identifying participants;(3)considering ethical issues;(4)planning logistical aspects;(5)developing the interview guide;(6)establishing trust and rapport;(7)conducting the interview;(8)memoing and reflection;(9)analysing the data;(10)demonstrating the trustworthiness of the research;and(11)presenting findings in a paper or report.Semistructured interviews provide an effective and feasible research method for family physicians to conduct in primary care research settings.Researchers using semistructured interviews for data collection should take on a relational focus and consider the skills of interviewing to ensure quality.Semistructured interviewing can be a powerful tool for family physicians,primary care providers and other health services researchers to use to understand the thoughts,beliefs and experiences of individuals.Despite the utility,semistructured interviews can be intimidating and challenging for researchers not familiar with qualitative approaches.In order to elucidate this method,we provide practical guidance for researchers,including novice researchers and those with few resources,to use semistructured interviewing as a data collection strategy.We provide recommendations for the essential steps to follow in order to best implement semistructured interviews in family medicine and primary care research settings. | Melissa DeJonckheere Lisa M Vaughn | 2019 | Family Medicine and Community Health2019，7，2： | 8 |
| 2 | Chest neoplasms with infectious etiologies显示文摘A wide spectrum of thoracic tumors have known or suspected viral etiologies.Oncogenic viruses can be classified by the type of genomic material they contain.Neoplastic conditions found to have viral etiologies include post-transplant lymphoproliferative disease,lymphoid granulomatosis,Kaposi's sarcoma,Castleman's disease, recurrent respiratory papillomatosis,lung cancer,malignant mesothelioma,leukemia and lymphomas.Viruses involved in these conditions include Epstein-Barr virus, human herpes virus 8,human papillomavirus,Simian virus 40,human immunodeficiency virus,and Human T-lymphotropic virus.Imaging findings,epidemiology and mechanism of transmission for these diseases are reviewed in detail to gain a more thorough appreciation of disease pathophysiology for the chest radiologist. | Carlos S Restrepo Melissa M Chen Santiago Martinez-Jimenez Jorge Carrillo Catalina Restrepo | 2011 | World Journal of Radiology2011，3，12： | 6 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 5 | Outcomes of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding显示文摘AIM:To evaluate weight loss and surgical outcomes of Roux-en-Y gastric bypass(RYGB)and laparoscopic adjustable gastric band(LAGB).METHODS:Data relating to changes in body mass index(BMI)and procedural complications after RYGB(1995-2009;n=609;116M:493F;42.4±0.4 years)or LAGB(2004-2009;n=686;131M:555F;37.2±0.4years)were extracted from prospective databases.RESULTS:Pre-operative BMI was higher in RYGB than LAGB patients(46.8±7.1 kg/m2vs 40.4±4.2 kg/m2,P<001);more patients with BMI<35 kg/m2underwent LAGB than RYGB(17.1%vs 4.1%,P<0.0001).BMI decrease was greater after RYGB.There were direct relationships between weight loss and pre-operative BMI(P<0.001).Although there was no difference in weight loss between genders during the first 3-year post-surgery,male LAGB patients had greater BMI reduction than females(-8.2±4.3 kg/m2vs-3.9±1.9kg/m2,P=0.02).Peri-operative complications occurred more frequently following RYGB than LAGB(8.0%vs0.5%,P<0.001);majority related to wound infection.LAGB had more long-term complications requiring corrective procedures than RYGB(8.9%vs 2.1%,P<0.001).Conversion to RYGB resulted in greater BMI reduction(-9.5±3.8 kg/m2)compared to removal and replacement of the band(-6.0±3.0 kg/m2).Twelve months post-surgery,fasting glucose,total cholesterol and low density lipoprotein levels were significantly lower with the magnitude of reduction greater in RYGB patients.CONCLUSION:RYGB produces substantially greater weight loss than LAGB.Whilst peri-operative complications are greater after RYGB,long-term complication rate is higher following LAGB. | Nam Q Nguyen Philip Game Justin Bessell Tamara L Debreceni Melissa Neo Carly M Burgstad Pennie Taylor Gary A Wittert | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 6 | 基层保健研究中的半结构化访谈:关系与严谨的平衡显示文摘半结构化深度访谈常用于定性研究,是健康服务研究中最常见的定性数据来源。这种方法通常包括研究者和参与者之间的对话,在可灵活调整的访谈协议框架下,辅以后续问题、调查和评价。该方法允许研究者收集开放式数据,探索参与者对某一特定主题的想法、感受和信念,深入研究个人问题,有时是敏感问题。本文旨在确定和描述在家庭医学和基层保健研究环境中设计和进行半结构化访谈的基本技能。本文回顾了有关半结构化访谈的文献,以确定在家庭医学和基层保健研究环境中使用这种方法的关键技能和内容。总的来说,半结构化访谈既需要关注关系,也需要促进技能的实践。技能包括:(1)确定研究的目的和范围;(2)确定参与者;(3)考虑道德伦理问题;(4)规划后勤方面;(5)制定访谈指南;(6)建立信任和融洽关系;(7)进行访谈;(8)记录和反思;(9)分析数据;(10)证明研究的可信程度;(11)在论文或者报告中展示研究结果。半结构化访谈为家庭医生在基层保健研究环境中进行研究提供了一种有效、可行的研究方法。采用半结构化访谈进行数据收集的研究者应关注关系,并注意访谈技能,以确保质量。半结构化访谈可以成为家庭医生、基层保健从业人员和其他卫生服务研究者用来了解个人想法、信念和经验的一个强有力工具。尽管如此,对于不熟悉定性方法的研究者来说,半结构化访谈可能让人感到害怕,颇具挑战。为了阐明这一方法,本文为研究者(包括新手和资源较少的研究者)提供了实践指导,使其能够运用半结构化访谈来进行数据收集。为了在家庭医学和基层保健研究环境中更好地实施半结构化访谈,本文给出了必要步骤的建议。 | Melissa DeJonckheere Lisa M Vaughn 赵新月(译) 韩建军 许岩丽 杨辉(审校) | 2019 | 中国全科医学2019，22，23： | 3 |
| 7 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 8 | Non-operative successful management of a perforated small bowel diverticulum显示文摘Jejunoileal diverticula are rare and generally asymptomatic.In the few cases of patients who develop complications such as diverticulitis,perforation,obstruction,and/or hemorrhage,conventional treatment consists of surgical resection.We describe a case of perforated jejunoileal diverticulum with localized abscess and highlight the merits of surgical vs medical management.The patient is a 77-year-old male who presented with sharp,constant abdominal pain just inferior to the umbilicus.Administration of intravenous antibiotics results in complete and long-term resolution of the patient’s symptoms.In this report,we establish a framework for safely treating perforated small bowel diverticulum without surgical exploration. | Melissa M Levack Maria Lucia Madariaga Haytham MA Kaafarani | 2014 | World Journal of Gastroenterology2014，20，48： | 3 |
| 9 | Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6显示文摘Mice carrying Collagen2a1-cre-mediated deletions of Lrp5 and/or Lrp6 were created and characterized.Mice lacking either gene alone were viable and fertile with normal knee morphology.Mice in which both Lrp5 and Lrp6 were conditionally ablated via Collagen2al-cre-mediated deletion displayed severe defects in skeletal development during embryogenesis.In addition,adult mice carrying Collagen2al-cre-mediated deletions of Lrp5 and/or Lrp6 displayed low bone mass suggesting that the Collagen2a1-cre transgene was active in cells that subsequently differentiated into osteoblasts.In both embryonic skeletal development and establishment of adult bone mass,Lrp5 and Lrp6 carry out redundant functions. | Cassie A Schumacher Danese M Joiner Kennen D Less Melissa Oosterhouse Drewry Bart O Williams | 2015 | Bone Research2015，3，4： | 3 |
| 10 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 11 | Forgotten node:A case report显示文摘Sister Mary Joseph nodule or node refers to a palpable nodule bulging into the umbilicus and is usually a result of a malignant cancer in the pelvis or abdomen.Traditionally it has been considered a sign of ominous prognosis.Gastrointestinal malignancies,most commonly gastric,colon and pancreatic cancer account for about 52% of the underlying sources.Gynecological cancers,most commonly ovarian and uterine cancers account for about 28% of the sources. | Patrick M Fratellone Melissa A Holowecki | 2009 | World Journal of Gastroenterology2009，15，39： | 2 |
| 12 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 13 | Skeletal Muscle Adaptations to Training under Normobaric Hypoxic Versus Normoxic Conditions显示文摘 | MELISSA L MACDOUGALL J D TARNOPOLSKY M A | 1997 | Med Sci Sports Exe1997，，29： | 1 |
| 14 | Global cancer sta- tistics显示文摘 | Ahmedin Jemal DVM Bray F Melissa M | 2011 | Cancer J Clin2011，61，2： | 1 |
| 15 | Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes显示文摘 | Gong A Y Pamela S T Melissa A M | 2003 | Am J Cell Physiol2003，25，6： | 1 |
| 16 | Global cancer sta-tistics显示文摘 | Jemal A Bray F Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 17 | M ethicllin-resistant staphy- lococcus aureus disease in three communities显示文摘 | Scott KF Jeffrey CH Melissa M | 2005 | N Engl J Med2005，352，： | 1 |
| 18 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 19 | Global cancer statistics 显示文摘 | Jemal A Bray F Melissa M | | CACancer J Clin0，61，2： | 1 |
| 20 | The Mechanism of Action of Multidrug-Resistance-Linked P-Glycoprotein显示文摘 | Zuben E. Sauna Melissa M. Smith Marianna Müller Kathleen M. Kerr Suresh V. Ambudkar | 2001 | Journal of Bioenergetics and Biomembranes2001，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员