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| 1 | Wnt activity defines colon cancer stem ceils and is regulated by the microenvironment 显示文摘 | Vermeulen L De Sousa E Melo F van der Heijden M | 2010 | Nat Cell Biol2010，12，5： | 1 |
| 2 | Beneficial effects of angiotensin-(1-7)against deoxycorticosterone acetate-induced diastolic dysfunction occur independently of changes in blood pressure显示文摘 | de Almeida PW Melo MB Lima Rde F | 2015 | Hypertension2015，66，2： | 1 |
| 3 | The developing caneer stern-cell model: clinical challenges and opportunities 显示文摘 | Vermeulen L de Sousa e Melo F Richel DJ | 2012 | Lancet Oncol2012，13，2： | 1 |
| 4 | Wnt activity definescolon cancer stem cells and is regulated hy the microenviron-ment显示文摘 | Vermeulen L De Sousa E Melo F | 2010 | Nat Cell Biol2010，12，5： | 1 |
| 5 | Wnt activity defines colon cancer stem cells and is regulated by the microenvironment显示文摘 | Vemeulen L De Sottsa E Melo F | 2010 | Net Cell Biol2010，12，5： | 1 |
| 6 | Short-term supervised inpatient physiotherapy exercise protocol improves cardiac autonomic function after coronary artery bypass graft surgery--a randomised controlled trial 显示文摘 | Mendes RG Similes RP De Souza Melo Costa F | 2010 | Disabil Rehabil2010，32，16： | 1 |
| 7 | Writ activity defines colon cancer stem cells and is regulated by the microenvironrrnt显示文摘 | Vermeulen L De Sousa E Melo F van der Heijden M et &l | | Nat Ce I Biol 201 O0，12，5： | 1 |
| 8 | Antinocicep-tive and anti-inflammatory kaempferol glycosides from Sedumdendroideum显示文摘 | De Melo G O Malvar Ddo C Vanderlinde F A | 2009 | J Ethnopharmacol2009，124，2： | 1 |
| 9 | The Open-ended Photo- thermal Cell with LiTaO3 and Its use in Determining the Photo- chemical Loss 显示文摘 | DE PAULA M H MELO FILHO S F | 2007 | Sensors and Actuators B2007，125，： | 1 |
| 10 | Wnt activity defines colon cancer stem cells and is regulated by the microenvironment显示文摘 | VERMEULEN L DE SOUSA E MELO F VAN DER HEIJDEN M | 2010 | Nat Cell Biol2010，12，5： | 1 |
| 11 | Wnt activity defines colon cancer stem cells and is regulated by the microenvironment显示文摘 | Vermeulen L De Sousa E Melo F van der Heijden M | 2010 | Nat Cell Biol2010，12，5： | 1 |
| 12 | Partitioning hard clustering algorithms based on multi- ple dissimilarity matrices 显示文摘 | de Carvalho F A T Lechevallier Y de Melo F M | 2012 | Pattern Recognition2012，45，1： | 1 |
| 13 | Maytenus erythroxylon Reissek(Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms显示文摘AIM To investigate the acute toxicity,phytochemical profile,antidiarrheal activity and mechanisms of action of Maytenus erythroxylon(M.erythroxylon)ethanol extract.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to evaluate a possible antimotility effect.KATP channels,nitric oxide,presynapticα2-adrenergic and tissue adrenergic receptors were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.RESULTS All tested doses of the extract(62.5,125,250 and 500 mg/kg)possessed antidiarrheal activity,with a significant decrease of the evacuation index.This activity is possibly related to a reduced gastric emptying(125,250 and 500 mg/kg)and to a decreased percentage of intestinal transit for all tested doses.That last effect seems to be modulated by nitric oxide,KATP channels and tissue adrenergic receptors.Besides,the extract also presented antisecretory effect due to a decrease of intestinal fluid accumulation.CONCLUSION The antidiarrheal effect of M.erythroxylon found in this study involves antimotility and antisecretory mechanisms that may be attributed to the chemical compounds found in this species:saponins,flavonoids,tannins,triterpenes and steroids. | Rodrigo de Oliveira Formiga Zelma Glebya Maciel Quirino Margareth de Fátima Formiga Melo Diniz Alexsandro Fernandes Marinho Josean Fechine Tavares Leonia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，24： | 1 |
| 14 | Anxio-Lytic- Like Effect of Carvacrol (5-Isopmpyl-2-Methylphenol) In- mic:Involvement with GABA Ergic Transmission显示文摘 | Melo F H Venancio E T De Sousa D P | 2009 | Fun- Dam Clin Pharmacol2009，24，4： | 1 |
| 15 | Cat eye syndrome and growth hormone deficiency with pituitary anomalies: a case report and review of the literature显示文摘 | MELO C GAMA -de -SOUSA S ALMEIDA F | 2013 | Gene2013，529，1： | 1 |
| 16 | Evaluation of the flexural strength of carbon fiber-, quartz fiber , and glass fiber based posts显示文摘 | Galhano G A Valandro L F de Melo R M | 2005 | J Endod2005，31，3： | 1 |
| 17 | Cancer Stem Cell Niche: The Place to Be显示文摘 | Borowski T De S ousa E Melo F Vermeulen L | 2011 | Cancer Res2011，71，3： | 1 |
| 18 | Three-year outcome after coronary stenting versus bypass surgery for the treatment of multivessel disease显示文摘 | Legrand VM Serruys PW Unger F van Hout BA Vrolix MC Fransen GM Nielsen TT Paulsen PK Gomes RS de Queiroz e Melo JM Neves JP Lindeboom W Backx B Arterial Revascularization Therapy Study (ARTS) Investigators | 2004 | Circulation2004，109，9： | 1 |
| 19 | Mechanical properties of Sialon显示文摘 | Da Silva C R M De Melo F C L De Macedo Silva O M | 1996 | Materials Science and Engineering:1996，209，12： | 1 |
| 20 | Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence 显示文摘 | Biet F Angela de Melo Marques M Grayon M | 2007 | Microbes Infect2007，9，2： | 1 |
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