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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 3 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 4 | A new role for reticulon-4B/NOGO- B in the intestinal epithelial barrier function and inflammatory bowel disease显示文摘 | Rodriguez-Feo JA Puerto M Fernandez- Mena C | 2015 | Am J Physiol Gastrointest Liver Physiol2015，308，2： | 1 |
| 5 | Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system显示文摘 | Mena C Christophe T Amine N | 2012 | PLoS ONE2012，7，42： | 1 |
| 6 | Using image analy- sis in the study of multiphase gas absorption 显示文摘 | Mena P C Pons M N Teixeira J A | 2005 | Chemi- cal Engineering Science2005，60，18： | 1 |
| 7 | Development of a tyrosinase biosensor based on gold nanoparticles-modified glassy car- bon electrodes: Application to the measurement of a bioelectrochemical polyphenols index in wines显示文摘 | SANZ V C MENA M L GONZ LEZ-CORT S A | 2005 | Anal Claim Aeta2005，528，1： | 1 |
| 8 | Development of a tyrosinase biosensor based on gold nanoparticles-modified glassy carbon electrodes application to the measurement of a bioelectroehemical polyphenols index in wines显示文摘 | SANZ V C MENA M L CORTES A G | 2005 | Anal China Acts2005，528，： | 1 |
| 9 | In vivo glutamine hydrolysis in the formation of extracellular glutamate in the injured rat brain显示文摘 | Mena F V Baab P J Zielke C L | 2000 | J Neurosci Res2000，60，5： | 1 |
| 10 | Biological permeable reactive barriers coupled with electrokinetic soil flushing for the treatment of diesel-polluted clay soil显示文摘 | Mena E Ruiz C Villasenor J | 2015 | Journal of Hazardous Materials2015，283，11： | 1 |
| 11 | Comprehensive analysis of gluten in processed foods using a new extraction method and a competitive ELISA based on the R5 antibody显示文摘 | Mena M C Lombardia M Hemando A | | 0，，15： | 1 |
| 12 | Effects of calcium antagonists on the dopamine system 显示文摘 | Mena M A Garcla de Y6benes M J Tabernero C | 1995 | Clin Neuropharmacol1995，18，5： | 1 |
| 13 | Congenital anomalies of the inferior vena cava:review of embryogenesis and presentation of a simplified classification显示文摘 | CHUANG V P MENA C E HOSKINS P A | 1974 | Br J Radiol1974，47，： | 1 |
| 14 | Removal of 2, 4, 6-tri- chlorophenol from spiked clay soils by electrokinetic soil flushing assisted with granular activated carbon permeable reactive barri- er 显示文摘 | Ruiz C Mena E Cafiizares P | 2013 | Industrial and Engineering Chemistry Research2013，53，2： | 1 |
| 15 | Removal of nitrates from spiked clay soils by coupling electrokinetic and permeable reac- tive barrier technologies 显示文摘 | Garcia Y Ruiz C Mena E | 2014 | Journal of Chemical Teclmol~Jg~ and Biotechnology2014，90，9： | 1 |
| 16 | Biological pem~eable re- active bmTiers coupled with electrokinetic soil flushing for the treatment of diesel-polluted clay soil 显示文摘 | Mena E Ruiz C Villasefior J | 2015 | Journal ~ Huzardous Materials2015，283，： | 1 |
| 17 | Identification of DNAbinding motifs of the Mycobacterium tuberculosis PhoP/PhoRtwo-component signal transduction System显示文摘 | Mena C Christophe T Amine N | 2012 | Plos One2012，7，42： | 1 |
| 18 | Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients 显示文摘 | Rushing E J Olsen C Mena H | 2005 | J Neurosurg2005，103，6： | 1 |
| 19 | Symmetrical ambulatory ar-terial stiffness index:relationship with microalbuminuria and renalfunction显示文摘 | Robles NR Mena C Macias R | 2010 | EurJ Intern Med2010，21，2： | 1 |
| 20 | Nitrate removal using natural clays modified by acid thermoactivation显示文摘 | C J Mena Duran M R Sun Kou T Lopez | 2007 | Surface Science2007，，253： | 1 |
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