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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The role of constraints within generalized nonextensive statistics显示文摘 | Tsallis C Mendes R S Plastino A R | 1998 | Physica A:Statistical Mechanics and its Applications1998，261，3： | 1 |
| 3 | Effect of transglutaminaseand carrageenan on restructured fish products containing dietaryfibres 显示文摘 | Cardoso C Mendes R Nunes M L | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 4 | Parameter estimation in biochemical pathway: a comparison of global optimization methods显示文摘 | Moles C G Mendes P Banga J R | 2003 | Genome Research2003，13，： | 1 |
| 5 | Pharmacodynamic comparisons of antimicrobials against nosocomial isolates of escherichia coli,klebsiella pneumoniae,acinetobacter baumannii and pseudomonas aeruginosa from the MYSTIC surveillance program:the OPTAMA Program,South America 2002显示文摘 | KIFFER C R MENDES C KUTI J L | 2004 | Diagn Microbiol Infect Dis2004，49，2： | 1 |
| 6 | Development of a healthylow-fat fishsausage containing dietary fibre 显示文摘 | Cardoso C Mendes R Nunes M L | 2008 | InternationalJournal of Food Science andTechnology2008，43，： | 1 |
| 7 | Nano- composite acrylic paint with self-cleaning action显示文摘 | CARNEIRO C VIEIRA R MENDES A M | 2012 | Jour- nal of Coatings Technology and Research2012，9，6： | 1 |
| 8 | Modeling and ride-through control of doubly fed induction generators during symmetrical voltage sags显示文摘 | Mendes V F de Sousa C V Silva S R | 2011 | IEEE Transactions on Energy Conversion2011，26，4： | 1 |
| 9 | Using immunology principles for fault detection显示文摘 | BRANCO P J C DENTE J A MENDES R V | 2003 | IEEE Transactions on Industrial Electronics2003，50，2： | 1 |
| 10 | Premedication in fibre-optic bronchoscopy from the patient's and the physician's viewpoint:a randomized study for the comparison of midazolam and hydrocodone显示文摘 | MENDES DE LEON C BEZEL R KARRER W | 1986 | Schweiz Med Wochenschr1986，116，5： | 1 |
| 11 | Parameter estimation in biochemical pathways: a comparison of global optimization method显示文摘 | Moles C G Mendes P Banga J R | 2003 | Genome Research2003，13，： | 1 |
| 12 | Instrumental texture and sensory characteristics of cod frankfurter sausages 显示文摘 | Cardoso C M L Mendes R Nunes M L | 2009 | International Journal of Food Properties2009，12，3： | 1 |
| 13 | Microbial biomass and activities in soil aggregates affected by winter cover crops 显示文摘 | MENDES I C BANDICK A K DICK R P | 1999 | Soil Science Society of America Journal1999，63，4： | 1 |
| 14 | Microbial biomass and activities in soil aggregates by winter cover crops显示文摘 | Mendes C Bandick A K Dick R P | 1999 | Soil Science Society of America Journal1999，63，： | 1 |
| 15 | q-Exponential,Weibull,and q-Weibull Distributions:An Empirical Analysis显示文摘 | MENDES R S MALACARNE L C | 2003 | Physica A2003，324，34： | 1 |
| 16 | Quality characteristics of high pressure-induced hake (Merluccius capensis) protein gels with and without MTGase 显示文摘 | Cardoso C L Mendes R O Saraiva J A | 2010 | Journal of Aquatic Food Product Technology2010，19，34： | 1 |
| 17 | Pharmacodynamie comparisons of antimierobials against nosocomial isolates of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa from the MYSTIC surveillance program: the OPTAMA Program, South America 2002 显示文摘 | KIFFER C R MENDES C KUTI J L | 2004 | Diagn Microbiol Infect Dis2004，49，2： | 1 |
| 18 | Microbial biomass and activities in soil aggregates affected by winter cover crops显示文摘 | MENDES I C BANDICK A K DICK R P | 1999 | Soil Science Society of America Journal1999，63，： | 1 |
| 19 | Biocompatibility testing of novel starch-based materials with potential ap- plication in orthopaedic surgery:a preliminary study 显示文摘 | Mendes S C Reis R L Bovell Y P | 2001 | Biomaterials2001，22，14： | 1 |
| 20 | Fabrication of phospholipid- xanthan microcapsules by combining microfluidics with self-assembly 显示文摘 | Mendes A C Baran E T Reis R L | 2013 | Acta biomaterialia2013，9，5： | 1 |
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