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| 1 | Prevalence of Opportunistic Pathogens and Diversity of Microbial Communities in the Water System of a Pulmonary Hospital显示文摘Objective Our objective was to investigate the occurrence of opportunistic pathogens and characterize the bacterial community structures in the water system of a pulmonary hospital.Methods The water samples were collected from automatic and manual faucets in the consulting room,treatment room,dressing room,respiratory ward,and other non-medical rooms in three buildings of the hospital.Quantitative polymerase chain reaction was used to quantify the load of several waterborne opportunistic pathogens and related microorganisms,including Legionella spp.,Mycobacterium spp.,and M.avium.Illumina sequencing targeting 16 S r RNA genes was performed to profile bacterial communities.Results The occurrence rates of Legionella spp.,Mycobacterium spp.,and M.avium were 100%,100%,and 76%,respectively in all samples.Higher occurrence rates of M.avium were observed in the outpatient service building(building 1,91.7%)and respiration department and wards(building 2,80%)than in the office building(building 3),where no M.avium was found.M.avium were more abundant in automatic faucets(average 2.21×10~4 gene copies/L)than in manual faucets(average 1.03×10~4 gene copies/m L)(P<0.01).Proteobacteria,Actinobacteria,Bacteroidetes,Cyanobacteria,Firmicutes,and Acidobacteria were the dominant bacterial phyla.Disinfectant residuals,nitrate,and temperature were found to be the key environmental factors driving microbial community structure shifts in water systems.Conclusion This study revealed a high level of colonization of water faucets by opportunistic pathogens and provided insight into the characteristics of microbial communities in a hospital water system and approaches to reduce risks of microbial contamination. | TANG Wei MAO Yu LI Qiu Yan MENG Die CHEN Ling WANG Hong ZHU Ren ZHANG Wei Xian | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 2 | SPAGINS:semiempirical parameterization for fragments in gamma-induced nuclear spallation显示文摘From the empirical phenomena of fragment distributions in nuclear spallation reactions,semiempirical formulas named SPAGINS were constructed to predict fragment cross-sections in high-energyγ-induced nuclear spallation reactions(PNSR).In constructing the SPAGINS formulas,theoretical models,including the TALYS toolkit,SPACS,and Rudstam formulas,were employed to study the general phenomenon of fragment distributions in PNSR with incident energies ranging from 100 to 1000 MeV.Considering the primary characteristics of PNSR,the SPAGINS formulas modify the EPAX and SPACS formulas and efficiently reproduce the measured data.The SPAGINS formulas provide a new and effective tool for predicting fragment production in PNSR. | Hui‑Ling Wei Meng‑Die Zhou Pu Jiao Yu‑Ting Wang Jie Pu Kai‑Xuan Cheng Ya‑Fei Guo Chun‑Yuan Qiao Gong‑Tao Fan Hong‑Wei Wang Chun‑Wang Ma | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 3 | Tetrahedral DNA Nanostructure-modified Gold Nanorod-based Anticancer Nanomaterials for Combined Photothermal Therapy and Chemotherapy显示文摘Objective To develop an effective treatment strategy to simultaneously avoid fatal adverse effects in the treatment of oral cancer,combination therapy has been explored because of its multiple functions.This work aims to develop a novel type of gold-nanorod-based nanomaterials decorated with tetrahedral DNA nanostructures(TDN)carrying antitumor drugs,namely,GNR@TDN-DOX nanocomposites.Methods In the designed structure,TDN,with a three-dimensional geometry composed of DNA strands,can provide GC base pairs for binding with the anticancer drug doxorubicin(DOX).The photothermal heating properties,biocompatibility properties,and antitumor performance of obtained GNR@TDN-DOX nanocomposites were investigated to assess their application potential in tumor treatment.Results Systematic studies have shown that the obtained GNR@TDN-DOX nanocomposites have high photothermal conversion under the illumination of an 808-nm infrared laser,leading to effective antitumor applications.In addition,the cell viability study shows that GNR@TDN-DOX nanocomposites have good biocompatibility.In vitro studies based on A375 cells show that the GNR@TDN-DOX nanocomposites can effectively eliminate cancer cells because of the combination of photothermal therapy induced by GNRS and chemotherapy induced by TDN-carrying DOX.The result shows that the obtained GNR@TDN-DOX nanocomposites have efficient cellular uptake and lysosome escape ability,together with their nuclear uptake behavior,which results in a significant antitumor effect.Conclusion This work has demonstrated a potential nanoplatform for anticancer applications. | WU Hao XU Jiang Shan LI Yan Hong WU Xing Han HU Wei LIU Meng Die SUN Qiang GUO Bin | 2022 | Biomedical and Environmental Sciences2022，35，12： | 0 |
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