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| 1 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 4 | Metabolites of Colletotrichum gloeosporioides,an eddophytic fungus in Artemisia mongolica显示文摘 | Zou W X Meng J C Lu H | 2000 | J Nat Prod2000，63，： | 1 |
| 5 | Studies on catalytic pyrolysis of heavy oils: reaction behaviors and mechanistic pathways 显示文摘 | Meng X H Xu C M Gao J S | 2005 | Appl Catal A Gen2005，294，： | 1 |
| 6 | A thermo-responsive affinity membrane with nano-structured pores and grafted poly(N-isopropylacrylamide) surface layer for hydrophobic adsorption显示文摘 | Meng T Xie R Chen Y C Cheng C J Li P F Ju X J Chu L Y | 2010 | Journal of Membrane Science2010，349，12： | 1 |
| 7 | Electrospray ionization for mass spectrometry of large biomolecules 显示文摘 | FENN J B MANN M MENG C K | 1989 | Science1989，246，： | 1 |
| 8 | Double-symmetric algebras显示文摘 | Bai C M Meng D J | 1997 | Chinese Science Bull etin1997，42，15： | 1 |
| 9 | Synthesis,crystal structure and magnetic properties of a new ion-pair complex benzyltriphenylphosphiniumbis(maleonitriledithiolato)nickel显示文摘 | Ni C L Li Y Z Meng Q J | 2005 | J Coord Chem2005，58，： | 1 |
| 10 | Metabolites of Colletotri churn gloeosporioides , an endophytic fungus in Artemisia mongoli- ca 显示文摘 | Zou W X Meng J C Lu H | 2000 | Journal of Natural Products2000，63，11： | 1 |
| 11 | Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners显示文摘 | Oldfield C J Meng J Yang J Y | 2008 | BMC Genomics2008，9，1： | 1 |
| 12 | Uncertainty analysis of irradiance non-uniformity measurementof pulsed solar simulator显示文摘 | He Y W Xiong L M Meng H F Liu D P Zhang J C | 2012 | Proceedings of SPIEThe International Society for Optical Engineering2012，8563，： | 1 |
| 13 | Regulation of Flower Development and Anthocyanin Accumulation in Gerbera hybrida 显示文摘 | MENG X C WANG X J | 2004 | J Hort Sci Biotech2004，79，1： | 1 |
| 14 | Production of light olefins by catalytic pyrolysis of heavy oil 显示文摘 | MENG X H XU C M GAO J S | 2006 | Pet Sci Technol2006，24，： | 1 |
| 15 | Giant magnetic-field-induced strains in Heusler alloy NiMnGa with modified composition显示文摘 | WU G H YU C H MENG L Q CFIEN J L YANG F M QI S R ZHAN W S WANG Z ZHENG Y F ZHAO L C | 1999 | Appl Phys Lett1999，75，19： | 1 |
| 16 | Faunal tumovers of Paleogene mammals from the Mongolian Plateau显示文摘 | Meng J McKenna M C | 1998 | Nature1998，394，： | 1 |
| 17 | Double-symmetric algebras and adjacent structure of Li ealgebras显示文摘 | Bai C M Meng D J | 1997 | Chinese Science Bulletin1997，43，12： | 1 |
| 18 | Antifungal highly oxygenated guaianolides and other constituents from Ajania fruticu-losa显示文摘 | MENG J C Hu Y F CHEN J H | 2001 | Phytochemistry2001，58，7： | 1 |
| 19 | Inhibition of activator protein 1 activity and cell growth by purified green tea polyphones in H-ras-transfOrmed cells: structure-activity relationship and mechanism involved 显示文摘 | Chung J Y Huang C Meng X | 1999 | Cancer Res1999，59，18： | 1 |
| 20 | Social capital,customer service orientation and creativity in retail stores显示文摘 | MERLOO BELL S J MENG(U)C B WHITWELL G J | | 0，，59： | 1 |
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