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| 1 | A hydrocarbon enrichment model and prediction of favorable accumulation areas in complicated superimposed basins in China显示文摘The geologic conditions of superimposed basins in China are very complicated. This is mainly shown by multi-phase structural evolution,multiple sets of source-reservoir-cap rock combinations,multiple stages of hydrocarbon generation and expulsion from source rocks,multi-cycle hydrocarbon enrichment and accumulation,and multi-phase reservoir adjustment and reconstruction. The enrichment,accumulation and distribution of hydrocarbon is mainly controlled by the source rock kitchen,paleoanticline,regional cap rock and intensity of tectonic movement. In this paper,the T-BCMS model has been developed to predict favorable areas of hydrocarbon accumulation in complicated superimposed basins according to time and spatial relationships among five key factors. The five factors include unconformity surface representing tectonic balancing(B) ,regional cap rock representing hydrocarbon protection(C) ,paleo-anticline representing hydrocarbon migration and accumulation(M) ,source rock kitchen representing hydrocarbon generation and expulsion(S) and geological time(T) . There are three necessary conditions to form favorable areas of hydrocarbon accumulation. First,four key factors BCMS should be strictly in the order of BCMS from top to bottom. Second,superimposition of four key factors BCMS in the same area is the most favorable for hydrocarbon accumulation. Third,vertically ordered combination and superimposition in the same area of BCMS should occur at the same geological time. The model has been used to predict the most favorable exploration areas in Ordovician in the Tarim Basin in the main hydrocarbon accumulation periods. The result shows that 95% of the discovered Ordovician hydrocarbon reservoirs are located in the predicted areas,which indicates the feasibility and reliability of the key factor matching T-BCMS model for hydrocarbon accumulation and enrichment. | Pang Xiongqi Meng Qingyang Jiang Zhenxue Liu Luofu Lu Xiuxiang | 2010 | Petroleum Science2010，7，1： | 16 |
| 2 | When water meets iron at Earth's core-mantle boundary显示文摘Hydrous minerals in subducted crust can transport large amounts of water into Earth's deep mantle. Our laboratory experiments revealed the surprising pressure-induced chemistry that, when water meets iron at the core-mantle boundary, they react to form an interlayer with an extremely oxygen-rich form of iron, iron dioxide, together with iron hydride. Hydrogen in the layer will escape upon further heating and rise to the crust, sustaining the water cycle. With water supplied by the subducting slabs meeting the nearly inexhaustible iron source in the core, an oxygen-rich layer would cumulate and thicken, leading to major global consequences in our planet. The seismic signature of the D″ layer may echo the chemical complexity of this layer. Over the course of geological time, the enormous oxygen reservoir accumulating between the mantle and core may have eventually reached a critical eruption point. Very large-scale oxygen eruptions could possibly cause major activities in the mantle convection and leave evidence such as the rifting of supercontinents and the Great Oxidation Event. | Ho-Kwang Mao Qingyang Hu Liuxiang Yang Jin Liu Duck Young Kim Yue Meng Li Zhang Vitali B.Prakapenka Wenge Yang Wendy L.Mao | 2017 | National Science Review2017，4，6： | 14 |
| 3 | The multi-factor recombination and processes superimposition model for hydrocarbon accumulation:application to the Silurian in the Tarim Basin显示文摘鉴于结构的进化, source-reservoir-seal 集合的多重集合,烃累积的多重周期和在建筑群的重新调整和重建的多重事件的多重事件的地质的特征附加了的烃,为烃累积的多因素再结合和过程重迭模型被提出在中国的盆。它是包括能帮助预言有利探索区域的理论和方法的一个系统。根据这个模型的意见,为在附加的盆的烃产生,进化和分发的基本纪律能在多因素再结合,过程重迭,油充满的多重阶段和最近的阶段保藏被总结。与是的 Tarim 盆的志留纪一个例子基于控制烃累积的四个因素(paleo背斜,来源岩石,地区性的帽子岩石和运动学的平衡带)的进化历史的重建,这个模特儿被收养预言有利的烃累积区域和在油充满的三个阶段跟随结构的破坏的有利探索区域,到在 Tarim basi | Meng Qingyang Pang Xiongqi Gao Jianbo | 2008 | Petroleum Science2008，5，1： | 8 |
| 4 | Multiple-Element Matching Reservoir Formation and Quantitative Prediction of Favorable Areas in Superimposed Basins显示文摘在韦斯特中国的附加的盆经历了多级式的构造事件和 multicycle 烃水库形成,并且复杂的烃水库在这种类型的盆广泛地被发现了。大多数复杂的烃水库被重定位,规模重建,部件变化和阶段国家转变描绘,并且他们的分布是很困难的预言。研究显示出那地区性的 caprock (C) ,高质量的沉积外形(存款, D ) , paleohighs (山, M ) 并且来源岩石(S) 是贡献复杂的烃水库形成和西方的附加的盆的分发的四个地质的元素。四个元素的纵的顺序的联合控制烃水库形成的阶层,并且平面重迭和联合控制烃水库的范围,他们在 geohistory 的同时的联合效果决定烃水库形成的时间。多重元素的匹配水库形成介绍水库形成的一个基本模式在里面附加的盆,和我们建议它被表示为 T-CDMS。基于多重元素的匹配水库形成模式,一个全面水库形成索引(Tcdms ) 在这篇论文被开发描绘水库形成条件,和一个方法被介绍在附加的盆预言水库形成范围和出现的概率。通过新理论,方法和技术的申请,在奥陶纪的出现的有利水库形成范围和概率在四个不同水库形成时期在 Tarim 盆指向地区被预言。结果证明中央 Tarim, Yinmaili 和 Lunnan 是奥陶纪油和煤气的地可能形成了的三个很有利的区域。有当前发现的烃水库的预言结果的巧合到达 97% 。这反映新理论,方法和技术的有效性和可靠性。 | WANG Huaijie PANG Xiongqi WANG Zhaoming YU Qiuhua HUO Zhipeng MENG Qingyang | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 8 |
| 5 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 6 | Alteration and Reformation of Hydrocarbon Reservoirs and Prediction of Remaining Potential Resources in Superimposed Basins显示文摘复杂的烃水库在从在早阶段形成的烃水库的多重结构的改变,改革和破坏形成的中国的附加的盆广泛地发展了。他们被陷井调整,部件变化,阶段变换,和规模改革当前描绘。这为由在烃水库形成以后并且为预言揭示进化机制指导当前的烃探索是重要的仍然是潜在的资源。基于很多座复杂的烃水库的分析,有四个地质的特征,控制在早阶段形成的烃水库的破坏的度:在构造进化期间为油和气体封上的构造事件紧张,频率,时间和 caprock。研究看那越大构造事件紧张,越多经常构造事件,以后的最后构造事件,越多更弱为油和气体封上的 caprock,并且更大在早阶段的破坏的烃的体积。基于关于烃水库破坏机制,构造重迭的一个地质的模型和评估潜在的留下的复杂的烃水库的一个数学模型的主要控制因素的研究被建立了。断言方法和技术过程在 Tarim 盆的 Tazhong 区域被使用,在烃累积的四个阶段和烃改变的三个阶段发生了的地方。Geohistorical 烃累积到达了 31.84 亿吨, 12.71 亿吨被破坏。仍然是为探索可得到的资源的全部的体积是 19 亿吨。 | PANG Hong PANG Xiongqi YANG Haijun LIN Changsong MENG Qingyang WANG Huaijie | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 4 |
| 7 | A method of identifying effective source rocks and its application in the Bozhong Depression,Bohai Sea,China显示文摘Research on effective source rocks directly affects the accuracy of identifying hydrocarbon resources, and indirectly affects the exploration decisions in petroliferous basins. Although the previous evaluation methods of effective source rocks vary relatively widely, a complete quantitative evaluation approach has not yet been developed. For that reason, we redefined the concept of effective source rocks based on the existing research results. Surrounding this definition, and guided by the hydrocarbon expulsion theory, the quantitative model called 'two stages and three steps' method is established to predict effective source rocks. Its application in the Bozhong Depression indicates that among the four sets source rocks in the Bozhong Depression, the Member 3 of the Shahejie Formation (Es 3 ) has the largest effective source rock thickness, and the Member 1 Member 2 of the Shahejie Formation (Es 1+2 ) is the second largest .The effective part of dark mudstone is only 30%-80% of the total volume and with the increase of buried depth and improvement of quality, the effective part increases. Comprehensive analysis indicates that the 'two stages and three steps' method is a practical technique for effective source rock prediction. | Jiang Fujie Pang Xiongqi Meng Qingyang Zhou Xiaohui | 2010 | Petroleum Science2010，7，4： | 3 |
| 8 | New WHO global air quality guidelines help prevent premature deaths in China显示文摘The air quality guidelines (AQGs) issued by the World Health Organization (WHO) in 2005 are key references for the National Ambient Air Quality Standards (NAAQSs) in China.On 22September 2021,the WHO issued new AQGs (NAQGs)[1],which propose more stringent targets to control exposure to multiple air pollutants,including fine particulate matter (PM_(2.5)) and ozone (O_(3)),to which,in 2019,451 million premature deaths,globally,were attributable [2]. | Tao Xue Guannan Geng Xia Meng Qingyang Xiao Yixuan Zheng Jicheng Gong Jun Liu Wei Wan Qiang Zhang Haidong Kan Shiqiu Zhang Tong Zhu | 2022 | National Science Review2022，9，4： | 3 |
| 9 | A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients显示文摘We sought to evaluate the efficacy and effects of low-dose tacrolimus (FK506) to recipients with living donor liver transplantation (LDLT). A total of 66 patients who underwent LDLT between 2001 and 2007 were enrolled in this study. According to different doses of tacrolimus, the recipients were randomly divided into two groups: the low-dose tacrolimus group (group A) and the normal-dose tacrolimus group (group B). The blood concentration of tacrolimus and its side effects including infection, hyperglycemia, hypertension, high blood creatinine and jaundice were monitored once a week at the perioperative period, and once a month thereafter. Besides, the survival rates of the recipients were analyzed at the 1and 3-year time point after operation. Among these patients, no significant acute rejection was detected after LDLT. The incidences of infection, hyperglycemia, liver dysfunction and renal impairment in group A were markedly lower than those in group B. However, no significant differences were detected in the incidence of hypertension between the two groups. Moreover, the recipients in each group had a similar survival rate according to the results of 1and 3-year follow-up. The incidence of side effects that associated with tacrolimus positively correlated with tacrolimus blood concentration. In conclusion, long-term and low-dose administration of tacrolimus is a safe and effective treatment for LDLT recipients. | Zhengshan Wu Qingyang Meng Yongxiang Xia Feng Zhang Wei You | 2013 | The Journal of Biomedical Research2013，27，4： | 3 |
| 10 | The evolution and present status of the study on peak oil in China显示文摘Peak oil theory is a theory concerning long-term oil reserves and the rate of oil production. Peak oil refers to the maximum rate of the production of oil or gas in any area under consideration. Its inevitability is analyzed from three aspects. The factors that influence peak oil and their mechanisms are discussed. These include the amount of resources, the discovery maturity of resources, the depletion rate of reserves and the demand for oil. The advance in the study of peak oil in China is divided into three stages. The main characteristics, main researchers, forecast results and research methods are described in each stage. The progress of the study of peak oil in China is summarized and the present problems are analyzed. Finally three development trends of peak oil study in China are presented. | Pang Xiongqi Zhao Lin Feng Lianyong Meng Qingyang Tang Xu LiJunchen | 2009 | Petroleum Science2009，6，2： | 2 |
| 11 | Petrologic and geochemical characteristics of high-quality saline lacustrine source rocks in western Qaidam Basin显示文摘The main oil source in western Qaidam Basin is the Paleogene saline lacustrine source rocks.Traditionally,it was considered that these source rocks were characterized by low abundance and poor type of organic matter as well as limited oil generation potential,but this poor source rock condition was very inconsistent with good hydrocarbon exploration results.A previous study has just confirmed that this area develops high-quality source rocks,which is of great significance for recognizing potential of hydrocarbon resource and consolidating confidence to search large and medium-sized oil and gas fields in western Qaidam Basin.Based on fine geochemical analysis of source rocks,petrology,element geochemistry and organic geochemistry are applied to discuss development conditions of high-quality source rocks in this area.The results showed that the saline lacustrine sediments in western Qaidam Basin were deposited in relatively shallow and quiet water with relatively high salinity and low nutrient content;influenced by the drought and cold climate,the terrigenous supply of fresh water was limited,and few aquatic organisms were developed.Good preservation condition is favorable for rapid preservation of oil generating biomass(such as aquatic organisms),to form source rocks rich in hydrogen element with high soluble organic matter content;but relatively lower paleo-productivity makes organic matter abundance lower than that in the eastern saline lacustrine basins.The semi-deep lake,with relatively low salinity and abundant nutrients,is the most favorable are for development of high-quality source rocks;the source rocks have large thickness in the sedimentary depression areas,but due to high water salinity and far away from the provenance area,the water stratification was obvious,so it have moderate to high organic matter abundance. | Bin Zhang Yuanyuan He Yan Chen Qingyang Meng Jiaxuan Huang Li Yuan | 2018 | Petroleum Research2018，3，4： | 2 |
| 12 | A Unified Analytical Framework for Ship Domains显示文摘 | Wang Ning Meng Xianyao Xu Qingyang Wang Zuwen | 2009 | The Journal of Navigation2009，，4： | 1 |
| 13 | LD-Pumped Random Fiber Laser Based on Erbium-Ytterbium Co-Doped Fiber显示文摘In this paper,a cladding-pumped erbium-ytterbium co-doped random fiber laser(EYRFL)operating at 1550 nm with high power laser diode(LD)is proposed and experimentally demonstrated for the first time.The laser cavity includes a 5-m-long erbium-ytterbium co-doped fiber that serves as the gain medium,as well as a 2-km-long single-mode fiber(SMF)to provide random distributed feedback.As a result,stable 2.14 W of 1550 nm random lasing at 9.80 W of 976 nm LD pump power and a linear output with the slope efficiency as 22.7%are generated.This simple and novel random fiber laser could provide a promising way to develop high power 1.5μm light sources. | Qingyang MENG Han WU Bing HAN Jiaqi LI Zinan WANG | 2020 | Photonic Sensors2020，10，2： | 1 |
| 14 | Bio- degradation Behavior of Poly(butylene adipate-cotereph- thalate((PBAT),Poly)lactic acid)(PLA),and Their Blend Under Soil Conditions显示文摘 | Weng Yunxuan Jin Yujuan Meng Qingyang | 2013 | Polymer TevSting2013，32，： | 1 |
| 15 | Mineralogy of the deep lower mantle in the presence of H_(2)O显示文摘Understanding the mineralogy of the Earth’s interior is a prerequisite for unravelling the evolution and dynamics of our planet.Here,we conducted high pressure-temperature experiments mimicking the conditions of the deep lower mantle(DLM,1800–2890 km in depth)and observed surprising mineralogical transformations in the presence of water.Ferropericlase,(Mg,Fe)O,which is the most abundant oxide mineral in Earth,reacts with H_(2)O to form a previously unknown(Mg,Fe)O_(2)H_(x)(x≤1)phase.The(Mg,Fe)O_(2)H_(x) has a pyrite structure and it coexists with the dominant silicate phases,bridgmanite and post-perovskite.Depending on Mg content and geotherm temperatures,the transformation may occur at 1800 km for(Mg_(0.6)Fe_(0.4))O or beyond 2300 km for(Mg_(0.7)Fe_(0.3))O.The(Mg,Fe)O_(2)H_(x) is an oxygen excess phase that stores an excessive amount of oxygen beyond the charge balance of maximum cation valences(Mg^(2+),Fe^(3+) and H^(+)).This important phase has a number of far-reaching implications including extreme redox inhomogeneity,deep-oxygen reservoirs in the DLM and an internal source for modulating oxygen in the atmosphere. | Qingyang Hu Jin Liu Jiuhua Chen Bingmin Yan Yue Meng Vitali B.Prakapenka Wendy L.Mao Ho-Kwang Mao | 2021 | National Science Review2021，8，4： | 1 |
| 16 | Numerical Investigation of the Influence of Fuel Concentration Gradient on Propane/Oxygen Detonation Propagation显示文摘In this paper,one-and two-dimensional numerical simulations are carried out to study the effects of fuel concentration gradients(such as steep,intermediate and shallow)on the detonation wave behavior.The equivalent ratio range of detonation propagation,the quenching mechanism and the change of cell size are discussed in detail.The simulation results show,as the fuel concentration gradient increases,the detonation wavefront decays faster and decouples into a leading shock and a following flame at equivalence ratios of 0.68,0.64 and 0.62,respectively.Moreover,there are two modes of the quenching mechanism.One occurs in the steep gradient that the detonation wave fails rapidly.The O_(2)in front of the detonation wave passes through the detonation wave and forms some unburned O_(2)pockets.The unburned pockets are affected by the marginal walls and reduce the heat release.The other occurs in the intermediate and shallow gradients that more triple points will survive in the flow field,which leads to a difference in the propagation speed of the detonation wavefront.This makes the detonation wavefront bent and deformed.The unburned O_(2)pockets are affected by the strong instability near the triple points and show different distribution characteristics compared with the steep gradient,which may be helpful to the detonation propagation.In addition,as the fuel concentration gradient increases,the triple points moving toward the wall gradually disappear while the triple points that move toward the center can continue to survive,which leads to the gradual increase in cell size and irregularity of the cell structure. | SHAO Xiaofeng WU Tianxing MENG Qingyang ZHAO Ningbo QI Lei ZHENG Hongtao | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 17 | Identification and evaluation of shale oil micromigration and its petroleum geological significance显示文摘Taking the Lower Permian Fengcheng Formation shale in Mahu Sag of Junggar Basin,NW China,as an example,core observation,test analysis,geological analysis and numerical simulation were applied to identify the shale oil micro-migration phenomenon.The hydrocarbon micro-migration in shale oil was quantitatively evaluated and verified by a self-created hydrocarbon expulsion potential method,and the petroleum geological significance of shale oil micro-migration evaluation was determined.Results show that significant micro-migration can be recognized between the organic-rich lamina and organic-poor lamina.The organic-rich lamina has strong hydrocarbon generation ability.The heavy components of hydrocarbon preferentially retained by kerogen swelling or adsorption,while the light components of hydrocarbon were migrated and accumulated to the interbedded felsic or carbonate organic-poor laminae as free oil.About 69% of the Fengcheng Formation shale samples in Well MY1 exhibit hydrocarbon charging phenomenon,while 31% of those exhibit hydrocarbon expulsion phenomenon.The reliability of the micro-migration evaluation results was verified by combining the group components based on the geochromatography effect,two-dimension nuclear magnetic resonance analysis,and the geochemical behavior of inorganic manganese elements in the process of hydrocarbon migration.Micro-migration is a bridge connecting the hydrocarbon accumulation elements in shale formations,which reflects the whole process of shale oil generation,expulsion and accumulation,and controls the content and composition of shale oil.The identification and evaluation of shale oil micro-migration will provide new perspectives for dynamically differential enrichment mechanism of shale oil and establishing a“multi-peak model in oil generation”of shale. | HU Tao JIANG Fujie PANG Xiongqi LIU Yuan WU Guanyun ZHOU Kuo XIAO Huiyi JIANG Zhenxue LI Maowen JIANG Shu HUANG Liliang CHEN Dongxia MENG Qingyang | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 18 | Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kαinhibitors显示文摘Phosphatidylinositol 3-kinase alpha(PI3Kα)inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma(ESCC).It is of great importance to identify potential biomarkers to predict or monitor the efficacy of PI3Kαinhibitors in an aim to improve the clinical responsive rate in ESCC.Here,ESCC PDXs with CCND1 amplification were found to be more sensitive to CYH33,a novel PI3Kα-selective inhibitor currently in clinical trials for the treatment of advanced solid tumors including ESCC.Elevated level of cyclin D1,p21 and Rb was found in CYH33-sensitive ESCC cells compared to those in resistant cells.CYH33 significantly arrested sensitive cells but not resistant cells at G1 phase,which was associated with accumulation of p21 and suppression of Rb phosphorylation by CDK4/6 and CDK2.Hypo-phosphorylation of Rb attenuated the transcriptional activation of SKP2 by E2F1,which in turn hindered SKP2-mediated degradation of p21 and reinforced accumulation of p21.Moreover,CDK4/6 inhibitors sensitized resistant ESCC cells and PDXs to CYH33.These findings provided mechanistic rationale to evaluate PI3Kαinhibitors in ESCC patients harboring amplified CCND1 and the combined regimen with CDK4/6 inhibitors in ESCC with proficient Rb. | Xu Zhang Yuxiang Wang Xi Zhang Yanyan Shen Kang Yang Qingyang Ma Yuemei Qiao Jiajie Shi Yi Wang Lan Xu Biyu Yang Gaoxiang Ge Landian Hu Xiangyin Kong Chunhao Yang Yi Chen Jian Ding Linghua Meng | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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