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| 1 | Dental and periodontal phenotype in sclerostin knockout mice显示文摘Sclerostin is a Wnt signalling antagonist that controls bone metabolism.Sclerostin is expressed by osteocytes and cementocytes;however,its role in the formation of dental structures remains unclear.Here,we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography(mCT)imaging.mCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls.mCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice.No significant differences were observed for the tooth and pulp chamber volume.Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width.Taken together,these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin. | Ulrike Kuchler Uwe Y Schwarze Toni Dobsak Patrick Heimel Dieter D Bosshardt Michaela Kneissel Reinhard Gruber | 2014 | International Journal of Oral Science2014，6，2： | 7 |
| 2 | Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator显示文摘Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative applications.In particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit X-rays.This betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial coherence.However,despite its unique features,the usability of the betatron source has been constrained by its poor control and stability.In this article,we demonstrate the reliable production of X-ray beams with tunable polarization.Using ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and controlled.We observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam divergence.The polarization ratio reaches 80%,and the polarization axis can easily be rotated.We anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications. | Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 3 | Roughley,MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein显示文摘 | Michaela D Hideaki N John S | 2011 | Matrix Biology2011，30，3： | 1 |
| 4 | Endophytic and ectophytic potato associated bacterial communities differ in structure and antagonistic function against plant pathogenic fungi 显示文摘 | GABRIELE B ANNETTE K MICHAELA D | 2005 | FEMS2005，51，： | 1 |
| 5 | Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase显示文摘 | Eike-Christin von Leitner Anna Klinke Dorothee Atzler Jessica L. Slocum Natalie Lund Jan T. Kielstein Renke Maas Robin Schmidt-Haupt Michaela Pekarova Olaf Hellwinkel Dimitrios Tsikas Louis G. D?Alecy Denise Lau Stephan Willems Lukas Kubala Heimo Ehmke Th | 2011 | Circulation2011，，24： | 1 |
| 6 | Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload: effects of betar receptor blockade显示文摘 | Grimm D Michaela H Jabusch HC | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 7 | Polyclonal,newly derived T cells with low expression of inhibitory molecule PD-1 in tonsils define the pheno- type of lymphocytes in children with Periodic Fever,Aphtous Stomatitls, Pharyngitis and Adenitis (PFAPA) syndrome显示文摘 | Petra D Petra K Michaela K | 2015 | Mol Immunol2015，，： | 1 |
| 8 | Combined exposure to hydrogen peroxide and lights selectiveeffects on Cyanobacteria, green algae ,and diatoms显示文摘 | Michaela D A Wim A Blahoslav M | 2007 | Environ Sci Technol2007，41，1： | 1 |
| 9 | Genetic diversity of pestiviruses: Identification of novel groups and implications for classification显示文摘 | Paul Becher Michaela Orlich Anthony d Ssannon | 1997 | J gen Virol1997，78，： | 1 |
| 10 | Extracelluar matrix proteins in cardiac fibroblasts derived from rat heart with chronic pressure overload: Effeels of hetar receptor blockadel显示文摘 | Grimm D Michaela H Jabusch HC | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 11 | Extraellular matrix proteins in cardiac fibroblasts derived form rat hearts with chronic pressure overload: effects of beta- receptor blockade显示文摘 | Grimm D Michaela Hub er Jabusch HC | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 12 | Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions显示文摘 | Johannes Prox Christian Bernreuther Hermann Altmeppen Jasper Grendel Markus Glatzel Rudi D’Hooge Stijn Stroobants Tariq Ahmed Detlef Balschun Michael Willem Sven Lammich Dirk Isbrandt Michaela Schweizer Katrien Horré Bart De Strooper Paul Saftig | 2013 | Journal of Neuroscience2013，，32： | 1 |
| 13 | Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia显示文摘 | Theo D K Seval T Michaela S | 2010 | haematologica2010，95，4： | 1 |
| 14 | Negative role of RIG-1 serine 8 phosphorylation in the regulation of in- terferon-13 production 显示文摘 | Estanislao N V Michaela U G Gustavo M D | 2009 | J Bio Chemis2009，285，26： | 1 |
| 15 | CD25-regulatory T cells and tumor immunity显示文摘 | Emma J Michaela D V Denise G | 2003 | Immunol Lett2003，85，2： | 1 |
| 16 | Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro显示文摘 | Michaela D Sabine F Yang S | 2014 | Plos One2014，9，89： | 1 |
| 17 | Endopphytic and ectophytic potato-associated bacterial communities differ in structure and antagonistic function against plant pathogenic fungi显示文摘 | Gabriele B Annette K Michaela D | 2005 | FEMS Microbiology Ecology2005，51，： | 1 |
| 18 | Polyclonal, newly derived T cells with low expression of inhibitory molecule PD - 1 in tonsils define the phenotype of lymphocytes in children with Periodic Fever, Aphtous Stomatitis, Pharyngitis and Adenitis (PFAPA) syndrome 显示文摘 | Petra D Petra K Michaela K | 2015 | Mol Immunol2015，65，1： | 1 |
| 19 | Endopphytic and ectophytic potato-associated bacterial communities differ in structure and antagonistic function against plant pathogenic fungi显示文摘 | Gabriele B Annette K Michaela D | 2005 | FEMS Microbiology Ecology2005，51，： | 1 |
| 20 | Fusobacterium necrophorum as the cause of recurrent sore throat:comparison of isolates from persistent sore throat syndrome and Lemierre's disease显示文摘 | Batty A Wren M W D Michaela G | 2005 | Journal of Infection2005，51，4： | 1 |
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