| 4 | Stereoselective Synthesis of 2,3,4,6-Tetrasubstituted Tetrahydropyrans显示文摘 The construction of stereodefined, highly substituted tetrahydropyrans has attracted a lot of interest over the years since they constitute ubiquitous fragments of numerous biologically active natural products.[1] During the course of our synthetic studies toward ambruticin, a fascinating antibiotic[2] which came back in the front scene with three recent total synthesis, [3] we have been interested in the synthesis of 2,3,4,6-tetrasubstituted tetrahydropyrans 5 (Scheme 1). [4] Moreover, this kind of subunit is found to be embedded in several other natural products such as lasonolide A, polycavernoside A, ratjadone, or concanamycin A.…… | GONG Jun-Fang WU Yang-Jie Véronique Micheletb Jean-Pierre Genêt b | 2003 | 有机化学2003，23，z1： | 0 |
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