|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 3 | 可视耳模拟系统:一种新颖的颞骨解剖教辅工具显示文摘学习掌握颞骨手术解剖学知识是开展耳外科手术的必要前提和必备基础。耳及颞骨的内部构造精细而复杂,并且紧邻面神经、颈部大血管和中后颅底等重要结构。为了全面准确地了解和掌握颞骨内部的复杂结构及毗邻关系。 | 黄孝文 余洋 Sorensen M S Mosegaard J Noe K Mikkelsen T P | 2011 | 临床耳鼻咽喉头颈外科杂志2011，25，22： | 2 |
| 4 | A 10-year survey, 1980- 1990, of prenatally diagnosed small supermumerary marker chro- mosomes identified by FISH analysis: Outcome and fallow-up of 14 cases diagnosed in a series of 12699 prenatal samples 显示文摘 | Brondum-Nielsen K Mikkelsen M | 1995 | Prenatal Diagn1995，15，： | 1 |
| 5 | Sea-level- andgas-hydrate-controlled catastrophic sediment failures ofthe Amazon Fan 显示文摘 | Maslin M Mikkelsen N Vilela C | 1998 | Geology1998，26，12： | 1 |
| 6 | Intracellular localisation and innate immune responses following Francisella noatunensis infection of Atlantic cod (Gadus morhua) macrophages 显示文摘 | Bakkemo K R Mikkelsen H Bordevik M | 2011 | Fish & Shellfish Immunology2011，31，6： | 1 |
| 7 | Electrokinetic instability mieromixing显示文摘 | Oddy M H Santiago J G Mikkelsen J C | 2001 | Analytical Chemistry2001，73，24： | 1 |
| 8 | Voltammetric DNA biosensor for cystic fibrosis based on a modified carbon paste electrode显示文摘 | Saraullo A Mikkelsen S R | 1994 | Anal Chem1994，，66： | 1 |
| 9 | Histopathological studies of sclerotia of phytopathogenic fungi parasitized by a GFP transformed Trichoderma virens antagonistic strain显示文摘 | Sarrocco S Mikkelsen L Vergara M | 2006 | Mycological Research2006，110，2： | 1 |
| 10 | Plant chitinases 显示文摘 | COLLINGE D B KRAGH K M MIKKELSEN J D | 1993 | The Plant Journal1993，3，1： | 1 |
| 11 | I solation of the promoters of Atlantic salmon MHC Ⅱ genes显示文摘 | Syed M Vestrheim O Mikkelsen B | 2003 | Mar Biotechnol(NY)2003，5，3： | 1 |
| 12 | Influencing cocoa flayour using Pichia kluyveriand Kluyveromyces marxianus in a defined mixed starter culture for cocoa fermentation显示文摘 | CRAFACK M MIKKELSEN M S(A)ERENS S | 2013 | International Journal of Food Microbiology2013，167，： | 1 |
| 13 | Lentiviral vectors for cutan- eous RNA managing显示文摘 | Primo M N Bak R O Mikkelsen J G | 2012 | Exp Dermatol2012，21，3： | 1 |
| 14 | Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa显示文摘 | Mikkelsen H Sivaneson M Filloux A | 2011 | Environ Microbiol2011，13，7： | 1 |
| 15 | Maternal fish oil supplementation in lactation : effect on visual acuity and n-3 fatty acid content of infant erythrocytes 显示文摘 | Lauritzen L Jorgensen SH Mikkelsen TB Skovgaard M Straarup EM Olsen SF | 2004 | Lipids2004，39，3： | 1 |
| 16 | Serum lactate is associated of organ failure and shock显示文摘 | MIKKELSEN M E MILTIADES A N GAIESKI D F | 2009 | Crit Care Med2009，37，5： | 1 |
| 17 | Ma- ternal fish oil supplementation in lactation: effect on visual acuity and n 3 fatty acid content of infant erythrocytes显示文摘 | LAURITZEN L J RGENSEN M H MIKKELSEN T B | 2004 | Lipids2004，39，3： | 1 |
| 18 | Self-limited growth of a thin oxide layer on Rh(111)显示文摘 | J Gustason A Mikkelsen M Borg | | 0，，92： | 1 |
| 19 | Altering Glucosinolate Profiles Modulates Disease Resistance in Plants 显示文摘 | BRADER G MIKKELSEN M D HALKIER B A | 2006 | The Plant Journal2006，46，5： | 1 |
| 20 | Influence of dif- ferent carbon sources on bacterial cellulose production by Glu- conacetobacter xylinus strain ATCC 53524显示文摘 | Mikkelsen D Flanagan B M Dykes G A | 2009 | Journal of Ap- plied Microbiology2009，107，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员