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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | 不同萃取技术获得的Artemisia sp的甲醇提取物其抗氧化和抗菌活性的比较(英文)显示文摘The polyphenol content,antioxidant and antimicrobial activities of the extracts obtained by classical, ultrasonic and Soxhlet extractions from dry aerial parts of two Artemisia species(Artemisia vulgaris and Artemisia campestris)were compared.Ultrasound positively affected the yield of extractive substance and the kinetics of extraction,but the extract obtained by the classical extraction showed the highest antioxidant activities and contained higher total contents of phenolic compounds and flavonoids than the extracts obtained by two other extraction techniques.Both flavonoid aglycones(apigenin,quercetin,quercetin 3,3′-dimethyl ether)and flavonoid glycosides(rutin,hyperoside and kaempferol 3-rhamnoside)were identified by thin layer chromatograph(TLC)analysis in the extracts from both species.A.campestris extracts were richer in quercetin than A.vulgaris and its antimicrobial activity was also better than A.vulgaris.Extracts obtained from both species were found to be more effective on the tested yeasts than bacteria.The kinetics of the total extractive substances,such as phenolic,flavonoids and quercetin extraction,was successfully described by the model of unsteady-state diffusion. | Ivana Karabegovi Milena Nikolova Dragan Velikovi Sаa Stojievi Vlada Veljkovi Miodrag Lazi | 2011 | Chinese Journal of Chemical Engineering2011，19，3： | 1 |
| 3 | Evaluation of genotoxic and antigenotoxic effects of hydroalcoholic extracts of Zuccagnia punctata Cav.显示文摘 | Iris Catiana Zampini Milena Villarini Massimo Moretti Luca Dominici María Inés Isla | 2007 | Journal of Ethnopharmacology2007，，2： | 1 |
| 4 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 5 | Cytokine levels(IL-6 and IFN-γ) acute phase response and nutritional status as prognostic actors in lung cancer显示文摘 | Antonio Milena Emilio González-Reimers María J Brito | 1999 | Cytokine1999，11，1： | 1 |
| 6 | Immediate occlusalloading of immediately placed implants supporting fixedrestorations in completely edentulous arches:a year pro-spective pilot study显示文摘 | Francesco P Nicolo A Milena F et a1 | 2009 | Journal of Periodontology2009，80，3： | 1 |
| 7 | Immediate Occlusal Loading of Immediately Placed Implants Supporting Fixed Restorations in Completely Edentulous Arches: A 1 -- Year Prospective Pilot Study 显示文摘 | Franeesco P Nicolo A Milena F | 2009 | Journal of Periodontology2009，80，3： | 1 |
| 8 | Mapping QTL for grain yield and plant traits in a tropical maize population显示文摘 | Milena A L Dyeme A V Anete P S | 2006 | Molecular Breeding2006，17，： | 1 |
| 9 | Polyurethane latex modified with polyaniline显示文摘 | IRINA SAPURINA JAROSLAV STEJSKAL MILENA ˇSP' IRKOV' A | 2005 | Synthetic Metals2005，151，2： | 1 |
| 10 | Dietary fish oil does not influence acute rejection rate and graft survival after renal transplantation:a randomized placebo-controlled study显示文摘 | HERNANDEZ D GUERRA R MILENA A | 2002 | Nephrol Dial Transplant2002，17，5： | 1 |
| 11 | Shelf-life modeling of ready-toeat coconut显示文摘 | Milena S Maria R C Daniela D A | 2003 | International Journal of Food Science and Technology2003，38，5： | 1 |
| 12 | Relations between mercury fractions and microbial community components in seawater under the presence and absence of probable phosphorus limitation conditions显示文摘Microbial transformations of toxic monomethylmercury(MMHg) and dissolved gaseous mercury(DGM) at the lower levels of the marine food web are not well understood, especially in oligotrophic and phosphorus-limited seas. To examine the effects of probable phosphorus limitation(~PP-limitation) on relations between mercury(Hg) fractions and microorganisms, we determined the total mercury(THg), total methylated mercury(MeHg), DGM, and microbiological and chemical parameters in the Central Adriatic Sea. Using statistical analysis, we assessed the potential microbial effects on Hg transformations and bioaccumulation. Only in the absence of ~PP-limitation conditions(^(NO–P)P-limitation) is MeHg significantly related to most chemical and microbial parameters, indicating metabolism-dependent Hg transformations.The heterotrophic activity of low nucleic acid bacteria(abundant in oligotrophic regions)seems responsible for most of Hg methylation under ^(NO–P)P-limitation. Under these conditions,DGM is strongly related to microbial fractions and chlorophyll a, indicating biological DGM production, which is probably not metabolically induced, as most of these relations are also observed underPP-limitation. MMHg biomagnification was observed through an increased bioaccumulation factor from microseston to mesozooplankton. Our results indicate that Hgtransformations and uptake might be enhanced under ^(NO–P)P-limitation conditions, emphasizing their impact on the transfer of Hg to higher trophic levels. | Igor ?ivkovi? Vesna Fajon Jo?e Kotnik Yaroslav Shlyapnikov Kristina Obu Vazner Ermira Begu Stefanija ?estanovi? Danijela ?anti? Ana Vrdoljak Slaven Jozi? Mladen ?oli? Jelena Lu?i? Jere Ve?a Grozdan Ku?pili? Marin Ordulj Frano Mati? Branka Grbec Natalia Bojani? ?ivana Nin?evi? Gladan Milena Horvat | 2019 | Journal of Environmental Sciences2019，31，1： | 1 |
| 13 | MiR-15a and miR-16 control Bmi-I expression in ovarian cancer显示文摘 | Resham B Milena N Rochelle A | 2009 | Cancer Res2009，69，23： | 1 |
| 14 | Total mercury, methylmercury and selenium in mercury polluted areas in the province Guizhou, China 显示文摘 | Horvat Milena Nolde Nataa Fajon Vesna Jereb Vesna Logar Martina Lojen Sonja | 2003 | The Science of the Total Environment2003，304，13： | 1 |
| 15 | Shelf-life modeling of ready-to-eat coconut显示文摘 | Milena S Maria R C Daniela D A | 2003 | International Journal of Food Science and Technology2003，38，： | 1 |
| 16 | Dietary fish oil does not influence acute rejection rate and graft survival after renal transplantation: a randomized placebo-controlled study 显示文摘 | Hernandez D Guerra R Milena A | 2002 | Nephrol Dial Transplant2002，17，5： | 1 |
| 17 | Huston,The interplay of facilitation and competition in plant communities显示文摘 | Milena Holmgren Marten Scheffer Michael A | 1997 | Ecology1997，78，7： | 1 |
| 18 | Mercury in an ultraoligotrophic North Patagonian Andean lake (Argentina): Concentration patterns in different components of the water column显示文摘The deep, ultraoligotrophic piedmont lakes of Northern Patagonia (Argentina) are located in pristine and barely impacted areas, along a wide latitudinal range. Several studies have reported moderate to high total mercury (Hg) concentrations and contrasting methylmercury (CH3Hg+) production in different lake compartments. Sources of Hg for western Patagonian terrestrial and aquatic ecosystems are still not clear; while point sources can be ruled out and atmospheric deposition is a plausible source, along with contribution from active volcanic areas of the Andes. In this investigation, we reported a noticeably seasonal, spatial (between lake branches), and vertical (between water column strata) heterogeneity in the total Hg concentrations found in the pelagic zone of Lake Moreno. Sterile water samples taken in a depth profile of the lake showed moderate to high concentrations of CH3Hg+ in autumn with a decreasing trend with depth. Our results indicated that Hg is largely allocated in the plankton fraction between 10–53 μm; which dominated within the euphotic (epilimnetic) zone of the lake due to the high densities attained by two species of the dinoflagellate Gymnodinium. The 53–200 μm planktonic size fraction (comprising rotifers, ciliates and immature stages of crustaceans) and the > 200 μm fraction (calanoid copepods and cladocerans) were found to bear strikingly lower total Hg concentrations, suggesting that the magnification of Hg at the planktonic consumer level is negligible. | María Arribére María C Diéguez Sergio Ribeiro Guevara Claudia P Queimalios Vesna Fajon Mariana Reissig Milena Horvat | 2010 | Journal of Environmental Sciences2010，22，8： | 1 |
| 19 | Adding value to the oil cake as a waste from oil processing indus- try :production of lipase and protease by Candida uti- lisin solid state fermentation显示文摘 | Omar A S M Sanja G Milena : | 2012 | Applied Biochemis- try and Biotechnology2012，166，2： | 1 |
| 20 | Sample preparation methods in the analysis of pesticide residues in baby food with subsequent chromatographic determination 显示文摘 | ANDREA H MILENA D A EVA M | 2007 | J Chromat A2007，1153，： | 1 |
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