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| 1 | YODA-HSP90 Module Regulates Phosphorylation-Dependent Inactivation of SPEECHLESS to Control Stomatal Development under Acute Heat Stress in Arabidopsis显示文摘Stomatal ontogenesis,patterning,and function are hallmarks of environmental plant adaptation,especially to conditions limiting plant growth,such as elevated temperatures and reduced water availability.The specification and distribution of a stomatal cell lineage and its terminal differentiation into guard cells require a master regulatory protein phosphorylation cascade involving the YODA mitogen-activated protein kinase kinase kinase.YODA signaling results in the activation of MITOGEN-ACTIVATED PROTEIN KINASEs(MPK3 and MPK6),which regulate transcription factors,including SPEECHLESS(SPCH).Here,we report that acute heat stress affects the phosphorylation and deactivation of SPCH and modulates stomatal density.By using complem entary molecular,genetic,biochemical,and cell biology approaches,we provide solid evidence that HEAT SHOCK PROTEINS 90(HSP90s)play a crucial role in transducing heat-stress response through the YODA cascade.Genetic studies revealed that YODA and HSP90.1 are epistatic,and they likely function linearly in the same developmental pathway regulating stomata formation.HSP90s interact with YODA,affectits cellular polarization,and modulate the phosphorylation of downstream targets,such as MPK6 and SPCH,under both normal and heat-stress conditions.Thus,HSP90-mediated specification and differentiation of the stomatal cell lineage couples stomatal development to environmental cues,providing an adaptive heat stress response mechanism in plants. | Despina Samakovli Tereza Ticha Tereza Vavrdova Miroslav Ovecka Ivan Luptovciak Veronika Zapletalova Anna Kucharova Pavel Krenek Yuliya Krasylenko Theoni Margaritopoulou Loukia Roka Dimitra Milioni George Komis Polydefkis Hatzopoulos Jozef Samaj | 2020 | Molecular Plant2020，13，4： | 9 |
| 2 | Association of Helicobacter pylori infection with cardiovascular disease—Is it just a myth?显示文摘 | Dimitrios K. Christodoulou Haralampos J. Milionis Panagiota Pappa Konstantinos H. Katsanos Dimitrios Sigounas Matilda Florentin Moses Elisaf Epameinondas V. Tsianos | 2010 | European Journal of Internal Medicine2010，，2： | 2 |
| 3 | Treatment of hyperlipidaemia with fenofibrate andrelated fibrates显示文摘 | Filippatos T Milionis HJ | 2008 | Expert Opin Investig Drugs2008，17，10： | 1 |
| 4 | A review of drug - induced hyponatremia 显示文摘 | Liamis G Milionis H Elisaf M | 2008 | Am J Kidney Dis2008，52，1： | 1 |
| 5 | The hyponatremic patient:a systematic approach to laboratory diagnosis显示文摘 | Milionis HJ Liamis GL Elisaf MS | 2002 | Can Med Assoc J2002，166，8： | 1 |
| 6 | Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals 显示文摘 | MILIONIS HJ LIBEROPOULOS E GOUDEVENOSJ | 2005 | Int J Cardiol2005，99，2： | 1 |
| 7 | Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects显示文摘 | Milionis HJ Rizos E Goudeveons J | 2005 | Stroke2005，36，： | 1 |
| 8 | Impact of renin angiotensin aldoste rone system genes on the treatment response of patients with hypertension and metabolic syndrome显示文摘 | Milionis HJ Kostapanos MS Vakalis K | 2007 | JRAAS2007，8，4： | 1 |
| 9 | Rosuvas- tatin treatment is associat-es with an increase in insulin resist- ance in hyperlipidaemie patients with impared fasting glucose 显示文摘 | Kostapanos MS Milionis HJ Agouridis AD | 2009 | In J Clin Pract2009，63，9： | 1 |
| 10 | Proprotein convertase subtilisin kexin 9 inhibitors : next generation in lipid-lowering therapy 显示文摘 | Milionis H Liamis G Elisaf M | 2015 | Expert Opin Biol Ther2015，15，2： | 1 |
| 11 | Components of the Metabolic Syndrome and Risk for First-Ever Acute Ischemic Nonembolic Stroke in Elderly Subjects显示文摘 | Rizos E Goudevenos J | 2005 | Stroke2005，36，： | 1 |
| 12 | The hyponatremic patient:a systematic approach to laboratory diagnosis显示文摘 | Milionis HJ Liamis GL Elisaf MS | 2002 | CMAJ2002，166，： | 1 |
| 13 | Fever with rash following zolendronic acid administration显示文摘 | Rizos EC Milionis HJ Elisaf MS | 2006 | Clin Exp Rheumatol2006，24，4： | 1 |
| 14 | Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia显示文摘 | Milionis H J Kakafika AI Tsouli SG | 2004 | Am Heart J2004，148，： | 1 |
| 15 | A review of drug-induced hyponatre- mia显示文摘 | Liamis G Milionis H Elisaf M | 2008 | Am J Kidney Dis2008，52，1： | 1 |
| 16 | Anemia on admission predicts short-and long-term outcomes in patients with acute ischemic stroke显示文摘 | Milionis H Papavasileiou V Eskandari A | 2014 | Int J Stroke2014，11，26： | 1 |
| 17 | Current role of statins in the treat- ment of essential hypertension显示文摘 | Kostapanos MS Milionis HJ Elisaf MS | 2010 | Expert Opin Pharmacother2010，11，16： | 1 |
| 18 | Ankle-brachial in- dex long-term outcome after first-ever ischaemic stroke显示文摘 | Milionis H Vemmou A Ntaios G | 2013 | Eur J Neurol2013，20，11： | 1 |
| 19 | Matabolic syndrome and its components as predictors of ischemic stroke in type 2 diabetic patient显示文摘 | Protopsaltis I Korantzopoulos P Milionis HJ | 2008 | Stroke2008，39，： | 1 |
| 20 | Combinatorial interaction of cis-elements specifies the expression of the Arabidopsis AtHsp90-1 gene显示文摘 | Haralampidis K Milioni D Rigas S | | 0，，129： | 1 |
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