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| 1 | Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography显示文摘AIM: To review the benefits of single photon emission computed tomography(SPECT)/computed tomography(CT) hybrid imaging for diagnosis of various endocrine disorders.METHODS: We performed MEDLINE and Pub Med searches using the terms: 'SPECT/CT'; 'functional anatomic mapping'; 'transmission emission tomography'; 'parathyroid adenoma'; 'thyroid cancer'; 'neuroendocrine tumor'; 'adrenal'; 'pheochromocytoma'; 'paraganglioma'; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts(case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this technology.RESULTS: The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the biodistribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for ^(99m)Tc-sestamibi parathyroid scintigraphy and ^(99m)Tc-pertechnetate thyroid scintigraphy, ^(123)I- or ^(131)I-radioiodine for staging of differentiated thyroid carcinoma, ^(111)In- and ^(99m)Tclabeled somatostatin receptor analogues for detection of neuroendocrine tumors, ^(131)I-norcholesterol(NP-59) scans for assessment of adrenal cortical hyperfunction, and ^(123)I- or ^(131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and paraganglioma.CONCLUSION: SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating to improved diagnostic accuracy and meaningful impact on patient care. | Ka-Kit Wong Arpit Gandhi Benjamin L Viglianti Lorraine M Fig Domenico Rubello Milton D Gross | 2016 | World Journal of Radiology2016，8，6： | 3 |
| 2 | Chemotactic motility is required for invasion of the host by the fish pathogen Vibrio anguillarum显示文摘 | O'Toole R Milton D L Wolf-Watz H | 1996 | Molecular Microbiol- ogy1996，19，3： | 1 |
| 3 | Cloning of a metalloprotease gene involved in the virulence mechanism of Vibrio anguillarum显示文摘 | Milton D L Norqvist A Wolf-Watz H | 1992 | J Bacteriol1992，174，22： | 1 |
| 4 | Chemical class separation and Characterization of organic compounds in synthetic fuels显示文摘 | Larter Douglas W Lee Milton L Bartle Keith D | 1981 | Analytical Chemistry1981，53，： | 1 |
| 5 | Chemical class separation and characterization of organic compounds in synthetic fuels显示文摘 | Later Douglas W Lee Milton L Bartle Kelth D | 1981 | Anal Chem1981，53，： | 1 |
| 6 | The upregulation of cognate and inducible heat shock proteins in the anoxic turtle brain 显示文摘 | Prentice H M Milton S L Scheurle D | 2004 | J~oumal of Cerebral Blood Flow & Metabolism2004，24，： | 1 |
| 7 | The basolateral amyg- dala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation 显示文摘 | Theberge F R Milton A L Belin D | 2010 | Learn Mem2010，17，9： | 1 |
| 8 | Heavy met als in stream sediments from copper and gold mining areas in southern Brazil显示文摘 | MARIA H D P MILTON L L F ELBA C T | 1997 | Journal of Geochemical Exploration1997，58，： | 1 |
| 9 | Surface properties,micellization,and premicellar aggregation of Gemini surfactants with rigid and flexible spacers显示文摘 | Song L D Milton J R | 1996 | Langmuir1996，12，： | 1 |
| 10 | Sequence of a novel virulence-mediating gene,virC,from Vibrio anguillarum 显示文摘 | Milton D L Norqvist A Wolf-Watz H | 1995 | Gene1995，164，1： | 1 |
| 11 | Flagellin A is essential for the virulence of Vibrio anguillarurn 显示文摘 | MILTON D L O'TOOLE R HORSTEDT P | 1996 | J Bacteriol1996，178，5： | 1 |
| 12 | Single-event burnout and avalanche characteristics of power DMOSFETs 显示文摘 | SANDRA L MILTON B GIRDHAR D A | 2006 | IEEE Trans Nuel Sci2006，53，6： | 1 |
| 13 | Surface properties, micellization, and premicellar aggregation of Gemini surfactants with rigid and flexible spacers 显示文摘 | SONG L D MILTON J R | 1996 | Langmuir1996，12，5： | 1 |
| 14 | Identification and characterization of additional flagellin genes from Vibrio anguillarum显示文摘 | MCGEE K HORSTEDT P Milton D L | 1996 | J Baeteriol1996，，： | 1 |
| 15 | A respective comparison of three techniques for femoral head and neck excision in dogs显示文摘 | Mnontgomery R D Milton J L Home R D | 1987 | Vet Surg1987，16，： | 1 |
| 16 | The REMATCH trial: rationale, design, and end points显示文摘 | Eric A Rose Alan J Moskowitz Milton Packer Josephine A Sollano Deborah L Williams Anita R Tierney Daniel F Heitjan Paul Meier Deborah Davis Ascheim Ronald G Levitan Alan D Weinberg Lynne Warner Stevenson Peter A Shapiro Ronald M Lazar John T Watson Daniel | 1999 | The Annals of Thoracic Surgery1999，，3： | 1 |
| 17 | A retrospective comparison of three techniques for femoral head and neck excision in dogs显示文摘 | Montgomery R D Milton J L Horne R D | 1987 | Vet Surg1987，16，6： | 1 |
| 18 | Cloning of a metalloprotease gene involved in the virulence mechanism of Vibrio anguillarum显示文摘 | MILTON D L NORQVIST A WOLF-WATZ H | 1992 | J Baeteriol1992，174，： | 1 |
| 19 | Surface properties, micellization, and premi- celler aggregation of Gemini surfactants with rigid and flexible spacers显示文摘 | Song L D Milton J R | 1996 | Langmuir1996，12，5： | 1 |
| 20 | Cloning of a metalloprotease gene involved in the virulence mecha nism of Vibrio anguillarum 显示文摘 | Milton D L Norqvist A Wolf-Watz H | 1992 | J Bacteriol1992，174，22： | 1 |
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