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| 1 | Multilayer black phosphorus as saturable absorber for an Er:Lu_(2)O_(3) laser at~3 μm显示文摘Multilayer black phosphorus(BP) nanoplatelets of different thicknesses were prepared by the liquid phase exfoliation method and deposited onto yttrium aluminum garnet substrates to form saturable absorbers(SAs). These were characterized with respect to their thickness-dependent saturable absorption properties at 3 μm. The BP-SAs were employed in a passively Q-switched Er:Lu_2O_3 laser at 2.84 μm. By using BP exfoliated in different solvents,stable pulses as short as 359 ns were generated at an average output power of up to 755 m W. The repetition rate in the experiment was 107 k Hz, corresponding to a pulse energy of 7.1 μJ. These results prove that BP-SAs have a great potential for optical modulation in the mid-infrared range. | Mingqi Fan Tao Li Shengzhi Zhao Guiqiu Li Xiaochun Gao Kejian Yang Dechun Li Christian Krankel | 2016 | Photonics Research2016，4，5： | 5 |
| 2 | Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma显示文摘RNA interference(RNAi)is one of the most promising methods for the treatment of malignant tumors.However,developing an efficient biocompatible delivery vector for small interfering RNA(siRNA)remains a challenging issue.This study aimed to prepare a non-viral tumor-targeted carrier,named RGDfC-modified functionalized selenium nanoparticles(RGDfC-SeNPs).RGDfC-SeNPs were used to selectively deliver siSox2 to HepG2 liver cancer cells and tissues for the treatment of hepatocellular carcinoma(HCC).In the current study,RGDfC-SeNPs were successfully synthesized and characterized.It was shown that RGDfC-SeNPs could effectively load siSox2 to prepare an antitumor prodrug RGDfC-Se@siSox2.RGDfC-Se@siSox2 exhibited selective uptake in HepG2 liver cancer cells and LO2 normal liver cells,indicating RGDfC-SeNPs could effectively deliver siSox2 to HepG2 liver cancer cells.RGDfC-Se@siSox2 entered HepG2 cells via clathrin-mediated endocytosis by firstly encircling the cytoplasm and then releasing siSox2 in the lysosomes.RGDfC-Se@siSox2 could effectively silence Sox2 and inhibit the proliferation,migration and invasion of HepG2 cells.RGDfC-Se@siSox2 induced HepG2 cells apoptosis most likely via overproduction of reactive oxygen species and disruption of the mitochondrial membrane potentials.Most importantly,RGDfC-Se@siSox2 significantly inhibited the tumor growth in HepG2 tumor-bearing mice without obvious toxic side effects.These studies indicated that RGDfC-SeNPs may be an ideal gene carrier for delivering siSox2 to HepG2 cells and that RGDfC-Se@siSox2 may be a novel and highly specific gene-targeted prodrug therapy for HCC. | Yu Xia Guoyi Tang Yi Chen Changbing Wang Min Guo Tiantian Xu Mingqi Zhao Yongjian Zhou | 2021 | Bioactive Materials2021，6，5： | 2 |
| 3 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 4 | Self-assembled inverted micelles prepared from a dendrimer template:phase transfer of encapsulated guests显示文摘 | Chechik V Crooks R M Zhao Mingqi | | 0，，20： | 1 |
| 5 | Preparation of highly impermeable hyperbranched polymer thin-film coatings using dendrimers first as building blocks and then as in situ thermosetting agents显示文摘 | Zhao Mingqi Liu Yuelong Crooks Richard M | 1999 | Journal of the American Chemical Society1999，121，5： | 1 |
| 6 | Hyperbranched polymer films and dendrimers显示文摘 | Zhao mingqi Sun L Crooks R M | | 0，，： | 1 |
| 7 | Hyperbranched Polymer Films and Dendrimers显示文摘 | Sun L Crooks R M | 1999 | Polym Prepr1999，40，： | 1 |
| 8 | Self-Assembled Inverted Micelles Prepared from a Dendrimer Template:Phase Transfer of Encapsulated Guests显示文摘 | Crooks R M Zhao Mingqi | 1999 | J Am Chem Soc1999，121，： | 1 |
| 9 | Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways显示文摘Emerging evidence that Enterovirus A 71(EV-A71)infection closely related to apoptosis.The ZVAD is a caspase inhibitor that can prevent apoptosis.The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs.In this study,after treated with ZVAD in EV-A71 infected Vero cells,the viral replication was reduced,and the cell viability was higher than EV-A71 group.Additionally,ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells.ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral. | TIANTIAN XU RUILIN ZHENG DANYANG CHEN HAIYANG CHEN MINGQI ZHAO MIN GUO YI CHEN CHANGBING WANG LU KUANG YINGHUA LI BING ZHU | 2022 | BIOCELL2022，46，4： | 1 |
| 10 | 显示文摘 | Chechik V Zhao Mingqi Crooks R M | 1999 | J Am Chem Soc1999，121，： | 1 |
| 11 | Influence of Annealing Temperature on Structural, Morphological and NH3 Sensing Properties of Nanostructured WO3 Porous Films显示文摘 | Shiguang Shang Ling Zhao Xin Li Mingqi Gao Ping Zhao Shan Zhao | 2014 | Integrated Ferroelectrics2014，，： | 1 |
| 12 | Preparation of Cu nanoclusters within dendrimer templates显示文摘 | ZHAO Mingqi SUN Li CROOK R M | 1998 | J Am Chem Soc1998，120，： | 1 |
| 13 | Homogeneous hydrogenation catalysis with monodisperse, dendrimer-encapsulated Pd and Pt nanoparticles显示文摘 | ZHAO Mingqi CROOK R M | 1999 | Angew Chem Int Ed Engl1999，38，： | 1 |
| 14 | 显示文摘 | Chechik V Zhao Mingqi Crooks R M | 1999 | J Am Chem Soc1999，121，： | 1 |
| 15 | Self-Assembled In- verted Micelles Prepared Dendrimer Template: Phase Transfer of Encapsulated Guests 显示文摘 | Chechik V Zhao Mingqi Crooks R M | 1999 | JAm Chem Soc1999，121，20： | 1 |
| 16 | Mutational spectrum of syndromic genes in sporadic brain arteriovenous malformation显示文摘Background:Brain arteriovenous malformations(BAVMs)are abnormal vessels that are apt to rupture,causing lifethreatening intracranial hemorrhage(ICH).The estimated prevalence of BAVMs is 0.05%among otherwise healthy individuals.In this study,we aim to investigate the mutational spectrum of syndromic genes in sporadic BAVM.Methods:We recruited a cohort of 150 patients with BAVM and performed whole-exome sequencing on their peripheral blood DNA.To explore the mutational spectrum of syndromic genes in sporadic brain arteriovenous malformation,we selected six genes according to the Online Mendelian Inheritance in Man(OMIM)and literature.All variants in the six candidate genes were extracted and underwent filtering for qualifying variants.Results:There are a total of four patients with rare variants in hereditary hemorrhagic telangiectasia-related genes.In addition,we identified two patients have the variant of RASA1 gene in our database,which are also rare mutations that are absent from population databases.However,we did not find any patients with GNAQ mutations in our database.Conclusions:In conclusion,we demonstrated that variants in syndromic vascular malformations play important roles in the etiology of sporadic BAVM. | Kun Wang Mingqi Zhang Sen Zhao Zhixin Xie Yisen Zhang Jian Liu Ying Zhang Xinjian Yang Nan Wu | 2022 | Chinese Neurosurgical Journal2022，8，2： | 0 |
| 17 | High-performance γ-MnO_(2) Dual-Core,Pair-Hole Fiber for Ultrafast Photonics显示文摘Manganese dioxide(MnO2)is a widely used and well-studied 3-dimensional(3D)transition metal oxide,which has advantages in ultrafast optics due to large specific surface area,narrow bandgap,multiple pores,superior electron transfer capability,and a wide range of light absorption.However,few studies have considered its excellent performance in ultrafast photonics.y-MnO2 photonics devices were fabricated based on a special dual-core,pair-hole fiber(DCPHF)carrier and applied in ultrafast optics fields for the first time.The results show that the soliton molecule with tunable temporal separation(1.84 to 2.7 ps)and 600-MHz harmonic solitons are achieved in the experiment.The result proves that this kind of photonics device has goodapplications in ultrafast lasers,high-performance sensors,fiber optical communications,etc.,which can help expand the prospect of combining 3D materials with novel fiber for ultrafast optics device technology. | Xiaohui Li Xiangzhen Huang Yueheng Han Enci Chen Penglai Guo Wenmin Zhang Mingqi An Zhiwen Pan Qian Xu Xiaoxiao Guo Xiwei Huang Yishan Wang Wei Zhao | 2023 | Ultrafast Science2023，3，1： | 0 |
| 18 | Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells显示文摘Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein(RBP)-specific aptamers,cap-dependent translation is rendered exclusively dependent on synthetic translation initiation factors(STIFs)containing different RBPs engineered to conditionally associate with different eIF4F-binding proteins(eIFBPs).This modular design framework facilitates the engineering of various gene switches and intracellular sensors responding to many user-defined trigger signals of interest,demonstrating tightly controlled,rapid and reversible regulation of transgene expression in mammalian cells as well as compatibility with various clinically applicable delivery routes of in vivo gene therapy.Therapeutic efficacy was demonstrated in two animal models.To exemplify disease treatments that require on-demand drug secretion,we show that a custom-designed gene switch triggered by the FDA-approved drug grazoprevir can effectively control insulin expression and restore glucose homeostasis in diabetic mice.For diseases that require instantaneous sense-and-response treatment programs,we create highly specific sensors for various subcellularly(mis)localized protein markers(such as cancer-related fusion proteins)and show that translation-based protein sensors can be used either alone or in combination with other cell-state classification strategies to create therapeutic biocomputers driving self-sufficient elimination of tumor cells in mice.This design strategy demonstrates unprecedented flexibility for translational regulation and could form the basis for a novel class of programmable gene therapies in vivo. | Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie | 2024 | Cell Research2024，34，1： | 0 |
| 19 | Advanced composite materials manufacturing technology显示文摘In recent years,a variety of composite materials preparation technology has been updated,from ceramic matrix composites,metal matrix composites to polymer matrix composites,a variety of preparation techniques have been greatly improved,making the composite properties and applications signifi cantly improved.This paper reviews several important preparation methods and applications of ceramic matrix composites,metal matrix composites and polymer matrix composites. | Zhijin Tang Hongliang Zhang Mingqi Sun Xiaoting Zhao | 2017 | Materials Science(Advanced Composite Materials)2017，1，1： | 0 |
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