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| 1 | A classification of some regular p-groups and its applications显示文摘In this paper we classify regular p-groups with type invariants (e, 1, 1, 1) for e ≥ 2 and (1, 1, 1, 1, 1). As a by-product, we give a new approach to the classification of groups of order p5, p ≥ 5 a prime. | ZHANG Qinhai SONG Qiangwei XU Mingyao | 2006 | Science China Mathematics2006，49，3： | 9 |
| 2 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis显示文摘Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA. | Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo | 2022 | Bone Research2022，10，2： | 7 |
| 3 | Symmetry properties of Cayley graphs of small valencies on the alternating group A_5显示文摘The normality of symmetry property of Cayley graphs of valencies 3 and 4 on the alternating group A5 is studied. We prove that all but four such graphs are normal;that A5 is not 5-CI. A complete classification of all arc-transitive Cayley graphs on A5 of valencies 3 and 4 as well as some examples of trivalent and tetravalent GRRs of A5 is given. | XU Mingyao XU Shangjin | 2004 | Science China Mathematics2004，47，4： | 7 |
| 4 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 5 | Finite p-groups with a minimal non-abelian subgroup of index p(Ⅲ)显示文摘This paper finishes the classification of three-generator finite p-groups G such that Φ(G) Z(G).This paper is a part of classification of finite p-groups with a minimal non-abelian subgroup of index p, and partly solves a problem proposed by Berkovich(2008). | QU HaiPeng XU MingYao AN LiJian | 2015 | Science China Mathematics2015，58，4： | 6 |
| 6 | Fractal characteristics and its application in electromagnetic radiation signals during fracturing of coal or rock显示文摘The present study analyzed the electromagnetic radiation(EMR) time series of the destruction process of coal or rock sample under uniaxial loading and the monitoring process in working face by means of fractal geometry,and results of the correlation dimension change curve of EMR time series were obtained.In the meantime,the current study also sought the fractal characteristic to the EMR signals by contrast to the change curve of EMR signals and explored the precursory phenomenon of rock burst.This paper concluded the main findings as followed:the EMR time series of the destruction process of coal or rock sample under uniaxial loading and the monitoring process in working face corresponded to fractal;the correlation dimension of EMR time series reflected the process of coal or rock damage deformation,that is,the inner damage of coal or rock made a change from random to order.In the field application,the correlation dimension served as a new index of forecasting the coal or rock dynamic disaster. | Wang Chao Xu Jiankun Zhao Xiaoxia Wei Mingyao | 2012 | International Journal of Mining Science and Technology2012，22，2： | 6 |
| 7 | Mesenchymal stem cell-based therapy for burn wound healing显示文摘Burns,with their high incidence and mortality rates,have a devastating effect on patients.There are still huge challenges in the management of burns.Mesenchymal stem cells(MSCs),which have multidirectional differentiation potential,have aroused interest in exploring the capacity for treating different intractable diseases due to their strong proliferation,tissue repair,immune tolerance and paracrine abilities,among other features.Currently,several animal studies have shown that MSCs play various roles and have beneficial effects in promoting wound healing,inhibiting burn inflammation and preventing the formation of pathological scars during burn healing process.The substances MSCs secrete can act on peripheral cells and promote burn repair.According to preclinical research,MSC-based treatments can effectively improve burn wound healing and reduce pain.However,due to the small number of patients and the lack of controls,treatment plans and evaluation criteria vary widely,thus limiting the value of these clinical studies.Therefore,to better evaluate the safety and effectiveness of MSC-based burn treatments,standardization of the application scheme and evaluation criteria of MSC therapy in burn treatment is required in the future.In addition,the combination of MSC pretreatment and dressing materials are also conducive to improving the therapeutic effect of MSCs on burns.In this article,we review current animal research and clinical trials based on the use of stem cell therapy for treating burns and discuss the main challenges and coping strategies facing future clinical applications. | Mingyao Wang Xinxuan Xu Xiongxin Lei Jie Tan Huiqi Xie | 2021 | Burns & Trauma2021，9，1： | 2 |
| 8 | Grain boundary optimization induced substantial squareness enhancement and high performance in iron-rich Sm-Co-Fe-Cu-Zr magnets显示文摘Increasing iron content has been witnessed an essential method to improve the remanence of 2:17-type Sm-Co-Fe-Cu-Zr magnets,however,the inferior squareness factor accompanied with the increased iron content turns into a neck sticking problem.In this work,the grain boundary optimization induced substantial squareness enhancement from 63.4%to 91.4%,and consequently an excellent maximum energy product of 32.63 MGOe have been achieved in iron-rich Sm-Co-Fe-Cu-Zr magnets via tuning solution process.It is clearly revealed that the grain boundary(GB)phases as well as the micro-twins’density in grain interiors can be controlled and interprets the enhancement mechanism of squareness. | Jun Cao Tianli Zhang Jinghua Liu Hao Xu Mingyao Hu Wei Xia Ao Wang Hui Wang Chengbao Jiang | 2021 | Journal of Materials Science & Technology2021，，26： | 2 |
| 9 | On the isomorphism problem of Cayley graphs of abelian groups显示文摘 | Xu Mingyao | 1998 | Discrete Math1998，，187： | 1 |
| 10 | A theorem on Metabelian p-groups And Some Consequences显示文摘 | MINGYAO XU | 1984 | Chin Ann Math1984，5，： | 1 |
| 11 | Metacyclic groups of prime-power order (Research announcement)显示文摘 | Newman M F Xu Mingyao | | 0，，： | 1 |
| 12 | A classification of metacyclic 2-groups显示文摘 | Xu Mingyao Zhang Qinhai | | 0，，： | 1 |
| 13 | Catalytic combustion of styrene over copper based catalyst:inhibitory effect of water vapor显示文摘 | Pan Hongyan Xu Mingyao Li Zhong | 2009 | Chemosphere2009，76，5： | 1 |
| 14 | Metacyclic groups of prime-power order显示文摘 | Newman M F and Xu Mingyao | 1987 | Preprint1987，，： | 1 |
| 15 | Classification of metacyclic 2- groups显示文摘 | Mingyao Xu and Qinhai Zhang | 2006 | Algebra Colluquim2006，13，6： | 1 |
| 16 | Finite p-groups all of whose non-abelian proper subgroups are metacyclic显示文摘 | LIJIAN AN MINGYAO XU | 2006 | Arch Math2006，87，： | 1 |
| 17 | Conjecture of Li and Praeger concerning the isomorphisms of Cayley graphs of A5显示文摘 | Mingyao Xu Xingui Fang Hyo-Seob Sim Young-Gheel Baik | 2001 | Science in China Series A: Mathematics2001，，12： | 1 |
| 18 | Metacyclic groups of prime-power order(Reserch annoucement) 显示文摘 | Newman M F and Xu Mingyao | 1988 | Adv in Math (Beijing)1988，17，： | 1 |
| 19 | Classification of metacyclic 2-groups显示文摘 | Mingyao Xu and Qinhai Zhang | 2006 | Algebra Colluquim2006，13，1： | 1 |
| 20 | Analysis of bina- ry cryogenic mixtures containing nitrogen and freon in cryocoolers 显示文摘 | Mingyao XU Yalin HE Zhongqi CHEN | 1996 | Cryogenics1996，36，： | 1 |
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