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| 1 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 2 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 3 | GM-CSF and SDF treatment induced neovasculogenesis in a mouse ischemic hindlimb model显示文摘 | Mireille AM Mark B Todd G | 2004 | Am Coll Surg2004，199，3： | 1 |
| 4 | Twice-daily versus once-daily applications of pimecrolimus cream 1% for the prevention of disease relapse in pediatric patients with atopic dermatitis 显示文摘 | Mireille RM Werner A Anthony G | 2009 | Pediatr Dermatol2009，26，5： | 1 |
| 5 | Assessment of exposure to traffic pollution using the ExTra index: study of validation 显示文摘 | Patrice R Mireille C Stepanie G | 2003 | Environmental Research2003，93，： | 1 |
| 6 | Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions 显示文摘 | Gregory G Philippe R Mireille G | 2004 | J Biol Chem2004，279，28： | 1 |
| 7 | Laser-induced damage thresholds of bulk and eoatingoptical materials at 1030nm, 500fs显示文摘 | LAURENT G MIREILLE C | 2014 | Applied Optics2014，53，4： | 1 |
| 8 | Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37 显示文摘 | Pascale N Helene G Mireille R | 2003 | Oncogene2003，22，： | 1 |
| 9 | Apoptisis participates in cellularity regulation during rat aortic intimal thickening 显示文摘 | Francoise G Mireille R | 1995 | Am J Pathol1995，146，： | 1 |
| 10 | Maize and sunflower biomass estimation in southwest France using high spatial and temporal resolution remote sensing data显示文摘 | Martin Claverie Valérie Demarez Beno?t Duchemin Olivier Hagolle Danielle Ducrot Claire Marais-Sicre Jean-Fran?ois Dejoux Mireille Huc Pascal Keravec Pierre Béziat Remy Fieuzal Eric Ceschia Gérard Dedieu | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 11 | Improving adverse drug reaction reporting in hospitals显示文摘 | MIREILLE G KATTALIN B AGNES S | 2010 | Drug Safety2010，33，5： | 1 |
| 12 | Renal tubular dys- genesis, a not uncommon autosomal recessive disorder leading to oligohydramnios : role of the renin- angiotensin system 显示文摘 | MIREILLE L CAI Y LILIANE G | 2006 | ASN2006，17，： | 1 |
| 13 | Diversity of puroindolines as revealed by two-dimensional electrophoresis显示文摘 | Gerard B Nardjis A Gilberto I Therese G Stephane H Mireille D Didier M | 2003 | Proteomics2003，3，： | 1 |
| 14 | Factors Affeeting University-Industry R&D Projects: The Importance of Searching, Screening and Signaling 显示文摘 | ROBERTO F ALDO G MIREILLE M | 2006 | Research Policy2006，35，2： | 1 |
| 15 | GM-CSF and SDF treatment induces neovasculogenesis in a mouse ischemic hind limb model显示文摘 | Mireille AM Mark B Todd G | 2004 | J Am Coll Surg2004，199，3： | 1 |
| 16 | GM-CSF and SDF treatment induces neovasculogenesis in a mouse ischemic hindlimb model显示文摘 | Mireille AM Mark B Todd G | 2004 | J American College Surgeons2004，199，3： | 1 |
| 17 | Development of virus-specific CD4^+T ceils on reexposure to varicella-zoster virus显示文摘 | Mireille T Vossen M Mi-Ran G | 2004 | Infectious Diseases2004，190，16： | 1 |
| 18 | Persistence of Mycoplasma gallisepticum in chickens after treatment with enrofloxacin without development of resistance显示文摘 | Anita K R Anne V G Mireille G | 2005 | Veterinary Microbiology2005，，106： | 1 |
| 19 | High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon显示文摘 | Anna?g Lan Mireille Andriamihaja Jean-Marc Blouin Xinxin Liu Véronique Descatoire Caroline Desclée de Maredsous Anne-Marie Davila Francine Walker Daniel Tomé Fran?ois Blachier | 2014 | The Journal of Nutritional Biochemistry2014，，： | 1 |
| 20 | Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer显示文摘BACKGROUND Inflammatory bowel disease(IBD)constitutes a substantial risk factor for colorectal cancer.Connexin 43(Cx43)is a protein that forms gap junction(GJ)complexes involved in intercellular communication,and its expression is altered under pathological conditions,such as IBD and cancer.Recent studies have implicated epigenetic processes modulating DNA methylation in the pathogenesis of diverse inflammatory and malignant diseases.The ten-eleven translocation-2(TET-2)enzyme catalyzes the demethylation,hence,regulating the activity of various cancer-promoting and tumor-suppressor genes.AIM To investigate Cx43 and TET-2 expression levels and presence of 5-hydroxymethylcytosine(5-hmC)marks under inflammatory conditions both in vitro and in vivo.METHODS TET-2 expression was evaluated in parental HT-29 cells and in HT-29 cells expressing low or high levels of Cx43,a putative tumor-suppressor gene whose expression varies in IBD and colorectal cancer,and which has been implicated in the inflammatory process and in tumor onset.The dextran sulfate sodium-induced colitis model was reproduced in BALB/c mice to evaluate the expression of TET-2 and Cx43 under inflammatory conditions in vivo.In addition,archived colon tissue sections from normal,IBD(ulcerative colitis),and sporadic colon adenocarcinoma patients were obtained and evaluated for the expression of TET-2 and Cx43.Expression levels were reported at the transcriptional level by quantitative real-time polymerase chain reaction,and at the translational level by Western blotting and immunofluorescence.RESULTS Under inflammatory conditions,Cx43 and TET-2 expression levels increased compared to noninflammatory conditions.TET-2 upregulation was more pronounced in Cx43-deficient cells.Moreover,colon tissue sections from normal,ulcerative colitis,and sporadic colon adenocarcinoma patients corroborated that Cx43 expression increased in IBD and decreased in adenocarcinoma,compared to tissues from non-IBD subjects.However,TET-2 expression and 5-hmC mark levels decreased in samples from patients with ulcerative colitis or cancer.Cx43 and TET-2 expression levels were also investigated in an experimental colitis mouse model.Interestingly,mice exposed to carbenoxolone(CBX),a GJ inhibitor,had upregulated TET-2 levels.Collectively,these results show that TET-2 levels and activity increased under inflammatory conditions,in cells downregulating gap junctional protein Cx43,and in colon tissues from mice exposed to CBX.CONCLUSION These results suggest that TET-2 expression levels,as well as Cx43 expression levels,are modulated in models of intestinal inflammation.We hypothesize that TET-2 may demethylate genes involved in inflammation and tumorigenesis,such as Cx43,potentially contributing to intestinal inflammation and associated carcinogenesis. | Mohammad El-Harakeh Jessica Saliba Kawthar Sharaf Aldeen May Haidar Layal El Hajjar Mireille Kallassy Awad Jana G Hashash Margret Shirinian Marwan El-Sabban | 2022 | World Journal of Gastroenterology2022，28，40： | 0 |
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