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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Antimyeloma effi cacy of plitidepsin ( aplidin (R) ) : from bench to the bedside 显示文摘 | Ocio EM Mitsiades C Mateos MV | 2007 | Blood2007，，： | 1 |
| 3 | Novel histone deacetylase inhibitors in the treatment of thyroid cancer显示文摘 | MITSIADES C S POULAKI V MCMULLAN C | 2005 | Clin Cancer Res2005，15，： | 1 |
| 4 | Regulation of vascular endothelial growth factor expression by insulin-like growth factorⅠin thyroid carcinomas显示文摘 | Poulaki V Mitsiades CS Mc Mullan C | 2003 | J Clin Endocrinol Metab2003，88，11： | 1 |
| 5 | Bortezomib:proteasome inhibition as an effective anticancer therapy显示文摘 | Richardson PG Mitsiades C | 2006 | Annu Rev Med2006，57，： | 1 |
| 6 | The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents:therapeutic applications显示文摘 | Mitsiades N Mitsiades C S Richardson PG | 2003 | Blood2003，101，6： | 1 |
| 7 | Regulation of Apo2L/tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Thyroid Carcinoma Cells 显示文摘 | Poulaki V Mitsiades C S Kotoula V | 2002 | Am J Pathol2002，161，： | 1 |
| 8 | Antimyeloma activity of heat shock protein-90 inhibition 显示文摘 | Mitsiades CS Mitsiades NS McMullan C J | 2006 | Blood2006，107，3： | 1 |
| 9 | Molecular mechanisms mediating antimyeloma activity of protea- some inhibitor PS-341显示文摘 | Hideshima T Mitsiades C Akiyama M | 2003 | Blood2003，101，4： | 1 |
| 10 | Molecular mechanisms mediating antimyelorna activity of proteasome inhibitor Ps341 显示文摘 | Hideshima T Mitsiades C Akiyama M | 2003 | Blood2003，101，4： | 1 |
| 11 | Regulation of vascular endothelial growth factor expres sion by insulin-like growth factor I in thyroid carcinomas显示文摘 | Poulaki V Mitsiades CS McMullan C | 2003 | J Clin Endocrinol Metab2003，88，11： | 1 |
| 12 | Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents,in multi- ple myeloma显示文摘 | Hideshima T Chauhan D Hayashi T Podar K Akiyama M Mitsiades C | 2003 | Cancer Res2003，63，： | 1 |
| 13 | Human retinoblastoma cells are resistant to apoptosis induced by death receptors:role of caspase-8 gene silencing 显示文摘 | Poulaki V Mitsiades CS Mcmullan C | 2005 | Invest Ophthalmol Vis Sci2005，46，1： | 1 |
| 14 | The Akt pathway: Molecular targets for anti-cancer drug development 显示文摘 | Mitsiades C S Mitsiades N Koutsilieris M | 2004 | Curr Cancer Drug Targets2004，4，2： | 1 |
| 15 | Mole- cular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341 显示文摘 | HIDESHIMA T MITSIADES C AKIYAMA M | 2003 | Blood2003，101，4： | 1 |
| 16 | Bortezomib: proteasome inhibition as an effective anticancer therapy 显示文摘 | Richardson PG Mitsiades C Hideshima T | 2006 | Annu Rev Med2006，57，： | 1 |
| 17 | Novel therapies in myeloma显示文摘 | Hayden P J Mitsiades C S Anderson K C Richardson P G | 2007 | Curr Opin Hematol2007，14，： | 1 |
| 18 | Molecular mechanisms cediating antimeloma activity of proteasome hnhibitor PS-341 显示文摘 | Hideshima T Mitsiades C Akiyama M | 2003 | Blood2003，101，： | 1 |
| 19 | Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets显示文摘 | Hideshima T Mitsiades C Tonon G | 2007 | Nat Rev Cancer2007，7，8： | 1 |
| 20 | Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies显示文摘 | Treon SP Mitsiades C Mitsiades N | 2001 | J Immunother2001，24，3： | 1 |
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