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| 1 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 2 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 3 | The male / female ratio of fetal deaths and births in Japan 显示文摘 | Mizuno R | 2000 | Lancet2000，，9231： | 1 |
| 4 | Inhibition of the ubiquitin-proteasome pathway activates stress kinases and induces apoptosis in renal cancer cells 显示文摘 | Ishizawa J Yoshida S Oya M Mizuno R Shinojima T Marumo K | 2004 | Int J Oncol2004，25，3： | 1 |
| 5 | Vaccination with tumor cell lysate-plused dendritic cell augment the effect of IFN-beta gene therapy for malignant glima in an experimental mose intracranial glioma显示文摘 | Saito R Mizuno M Nakahara N | 2004 | Cancer2004，111，5： | 1 |
| 6 | The male/female ratio of fetal deaths and births in Japan显示文摘 | Mizuno R | 2000 | Lancet2000，356，9231： | 1 |
| 7 | Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences显示文摘 | Ogawa R Mizuno H Watanabe A | 2004 | Biochem Biophys Res Commun2004，319，： | 1 |
| 8 | Modulation of bel-2 family pro- teins in MAPK independent apoptosis induced by a edc25 phos- phatase inhibitor Cpd 5 in renal cancer cells显示文摘 | Mizuno R Oya M Hara S | 2005 | Oneol Rep2005，14，3： | 1 |
| 9 | Immunohistochemieal demonstration of proliferating lymphatic vessels in eoloreetal carcinoma and its clinicopathological significance显示文摘 | Omaehi T Kawai Y Mizuno R | 2007 | Cancer Lett2007，246，12： | 1 |
| 10 | Estimation of the fight ventrieular volume and ejection fraction by transthoraeie three - dimensional eehoeardiography a validation study using magnetic resonance imaging显示文摘 | Fujimoto S Mizuno R Nakagawa Y | 1998 | Int J Card Imaging1998，14，： | 1 |
| 11 | Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences显示文摘 | Ogawa R Mizuno H Watanabe A | 2004 | Biochem Biophys Res Commun2004，319，2： | 1 |
| 12 | Osteogenic and chondrogenic differentiation by adipose-derived stem cel s harvested from GFP transgenic mice显示文摘 | Ogawa R Mizuno H Watanabe A | | 0，，04： | 1 |
| 13 | Influence of living style and situation on the compliance of taking antihypertensive agents in patients with essential hypertension显示文摘 | Mizuno R Fujimoto S Uesugi A | 2008 | Intern Med2008，47，19： | 1 |
| 14 | Inhibition of MKP21 expression potentiates JNK related apoptosis in renal cancer cells显示文摘 | Mizuno R Oya M Shiomi T | 2004 | J Urol2004，172，2： | 1 |
| 15 | Role of neurotensin receptor 1 in the regula- tion of food intake by neuromendins and neuromedin-related peptides 显示文摘 | Kim E R Mizuno T M | 2010 | Neuroscience Letters2010，468，： | 1 |
| 16 | Bisebromoamide, an extract from lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells显示文摘 | Suzuki K Mizuno R Suenaga K | 2013 | Cancer Med2013，2，1： | 1 |
| 17 | High-power and superpower Cerenkov masers显示文摘 | De Groot J S Stone R A Mizuno K | 1988 | IEEE Trans Plasma Sci1988，16，2： | 1 |
| 18 | Effects of Emulsifying Salts on the Turbidity and Calcium-Phosphate-Protein Interactions in Casein Micelles显示文摘 | R Mizuno J A Lucey | 2005 | Journal of Dairy Science2005，88，9： | 1 |
| 19 | MALAT -1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes 显示文摘 | Tano K Mizuno R Okada T | 2010 | FEBS Lett2010，584，22： | 1 |
| 20 | Two steroidal alkaloid glu- cosides fromveratrum taliense显示文摘 | Mizuo Mizuno Tan R X Zhen P | 1990 | Phytochemistry1990，29，1： | 1 |
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