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| 1 | 华南地区中生代Cu-(Mo)-W-Sn矿床成矿作用与洋岭/转换断层俯冲显示文摘华南地区是我国重要的金属矿产资源产地,除了发育大量的钨锡钼铋和稀土等金属矿产外,还有铜金矿床分布。本文通过对华南地区29个典型Cu-Mo-W-Sn矿床的时空分布及其与之有关的花岗质岩体的侵位年龄分析,探讨了与不同成矿类型有关的花岗质岩石的地球化学特征。本文认为华南地区10个典型的与Cu有关的矿床主要发生在180~170Ma、160~150Ma以及105~90Ma三个时期,而10个钨矿床主要集中于170~130Ma;4个W-Sn矿床集中于170~130Ma和120~110Ma;而5个Sn矿床则发育于170~150Ma、130~110Ma以及100~90Ma三个时期。Cu矿床主要与同熔型花岗岩有关,而Mo、W-Sn既与同熔型花岗岩有关,又与改造型花岗岩有关。在岩石地球化学上,与Cu-(Mo)-W-Sn成矿作用有关的花岗质岩石也表现出不同的地球化学特点,如,从Cu-(Mo)矿床到W-Sn矿床SiO2含量有逐渐增大、氧化性逐渐降低、还原性逐渐增加以及分异演化程度有逐渐增高的趋势。与Cu-(Mo)-Au矿床有关的花岗质岩石具有较低的SiO2(60.3%~68.1%),氧化性较高(Fe2O3/FeO=0.31~1.81),分异演化程度较低(Rb/Sr=0.05~3.3)的特点;与Cu-(Pb)-(Zn)矿床有关的花岗质岩石具有相对较高的SiO2(73.3%~75.2%),氧化性稍高(Fe2O3/FeO=0.68~1.74),分异程度稍低(Rb/Sr=10.8~57.8)的特点;而与Mo矿床有关的花岗质岩石具有较宽的SiO2(67.3%~76.2%)变化范围,氧化性稍低(Fe2O3/FeO=0.68~1.74),分异演化程度稍低(Rb/Sr=0.6~9.29);与W矿有关的花岗质岩石的SiO2含量为69.9%~80.1%,还原性稍低(Fe2O3/FeO=0.19~0.76),分异演化程度稍高(Rb/Sr=21.9~61.7);与W-Sn矿床有关的SiO2为74.8%~78.7%,还原性较低(Fe2O3/FeO=0.08~0.59),分异程度较高(Rb/Sr=10.8~139);与Sn矿床有关的花岗质岩石的SiO2为64.8%~76.9%,还原性高(Fe2O3/FeO=0.01~0.58),分异演化程度高(Rb/Sr=1~530)。在结合华南地区花岗岩类岩石的分布特征以及盆岭构造的特点,本文提出华南地区Cu-Mo-W-Sn矿床的成矿作用是不同时期大洋板块或者洋岭多阶段俯冲结果的新成因模型,即早侏罗世休眠的Farallon-Izanagi洋岭俯冲导致早—中侏罗世Cu成矿作用;中—晚侏罗世活动的Farallon-Izanagi洋岭和转换断层俯冲是中晚侏罗世Cu-(Mo)-(W)成矿作用以及多阶段W-Sn成矿作用的触发动力,而白垩纪Izanagi大洋板块俯冲则是白垩纪斑岩型Cu-W-Sn成矿作用的诱因。该模型的提出较好地解释了华南中生代大规模岩石圈拆沉—减薄—伸展的机制及其大规模成矿作用的动力。 | 李晓峰 Watanabe Yasushi 华仁民 毛景文 | 2008 | 地质学报2008，82，5： | 78 |
| 2 | 江西永平铜矿花岗质岩石的岩石结构、地球化学特征及其成矿意义显示文摘江西永平铜矿位于华南怀玉山—北武夷山铜铅锌多金属成矿带内,是赣东北地区除了德兴铜矿外的另一个大型铜矿基地。该矿区存在两种类型的花岗质岩石,一种是花岗岩;另一种是英安斑岩。英安斑岩具有典型斑状结构和石英眼结构,而花岗岩则具有单向固结结构。在化学成分上,两者属于高钾的钙碱性系列岩石,英安斑岩贫硅、富Al、Fe、Mg、Ca,以及具有较大的Na_2O/K_2O(0.02~0.64)等特点;而花岗岩富硅、贫Al、Ca,以及富碱和具有较小的Na_2O/K_2O(0.02~0.03)等特点。两种类型的岩石具有一致的REE配分曲线。它们均富集大离子亲石元素(Ba、Rb、K),亏损高场强元素(Th、Nd、Ta、Ti)以及元素Sr和P,显示了与俯冲作用有关的岩浆作用。在结构和化学成分上,花岗岩则类似于美国Climax斑岩钼(铜)矿成矿斑岩的性质(如具有单向固结结构、较高的分异指数、富Si、贫Al、Ca、富Na_2O+K_2O以及K_2O>Na_2O)。与英安斑岩有关的蚀变作用主要有夕卡岩化、黑云母化、白云母化、绿泥石化和萤石化,而与花岗岩有关的蚀变作用主要是白云母化和萤石化;相应地,与英安斑岩有关的成矿作用主要为铜,而与花岗岩有关的成矿作用则主要为钼。2件辉钼矿样品的Re-Os年龄分别为156.7±2.8Ma和155.7±3.6Ma,表明与花岗岩有关的钼成矿作用发生在156Ma左右。本文认为,永平铜钼矿的成矿地球动力学背景应是由挤压向伸展的转换环境。 | 李晓峰 Yasushi Watanabe 屈文俊 | 2007 | 岩石学报2007，23，10： | 42 |
| 3 | 铟矿床研究现状及其展望显示文摘铟是一种稀有金属,它在高科技产业中的应用价值越来越受到人们的普遍关注。由于供求矛盾突出,其消费价格水平不断上涨。目前,世界矿业界在铟业投入的技术和资金支持不断增加,以寻求满足日益增长的经济发展的需求。但相对来说,与铟有关的地质工作程度较低,新探明的储量远远跟不上其消费的增长水平,因此,有必要加大地质投入,探求新的资源量,保障世界经济可持续发展的要求。文章在总结前人研究成果的基础上,综述了世界上铟矿床的分布及其地质构造背景,以及铟矿物学、矿床成因和成矿机制等方面的最新研究成果。文章指出,为了寻找潜在的铟资源,必须加强铟的基础地质研究工作,在对铟的成因矿物学、成矿机制及其成矿环境进行深入系统研究的基础上,建立铟矿床的成矿模型和找矿勘查模型。 | 李晓峰 Watanabe Yasushi 毛景文 | 2007 | 矿床地质2007，26，4： | 39 |
| 4 | Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration显示文摘瞄准:在胃肠的基质肿瘤(大意) 的外科手术前的诊断评估内视镜的指导 ultrasonography 的好针渴望(EUS-FNA ) 的角色。方法:从 2002 年 9 月到 2006 年 6 月,有到合适的肌肉层的连续性的上皮的低亚硫酸钠拟声肿瘤由标准 EUS 作为大意怀疑了的官方补给的道潜水艇的 53 连续 EUS-FNAs 有希望地被评估。为最后的诊断的参考标准是外科(n = 31 ) ,或临床的后续(n = 22 ) 。另外,标本的免疫 phenotyping 由 EUS-FNA 获得了,外科的切除术标本被比较。结果:因为解剖问题,没在 2 情况刺被执行。从官方补给的道的足够的标本的收集率与连续性代替上皮的低亚硫酸钠拟声肿瘤到合适的肌肉层是 82%(42/51 ) 。为肿瘤的诊断的率不到 2 厘米, 2 ~ 4 厘米,和 4 厘米或更多是 71%(15/21 ) , 86%(18/21 ) ,并且 100%(9/9 ) 分别地。在 29 通过手术用免疫的 EUS-FNA 的 resected 盒子,敏感,特性,积极预兆的价值,否定预兆的价值,和诊断精确性大意的组织化学的分析是100%( 24/24 ),80%( 4/5 ),96%( 24/25 ),100%( 4/4 ),并且97%( 28/29 )分别地。没有主要复杂并发症被遇到。结论:有免疫的 EUS-FNA 组织化学的分析是在大意的 prethera-peutic 诊断的一个安全、精确的方法。它应该在决策被考虑,特别在跟随为大意的最小的侵略外科的早诊断。 | Kazuya Akahoshi Yorinobu Sumida Noriaki Matsui Masafumi Oya Rie Akinaga Masaru Kubokawa Yasuaki Motomura Kuniomi Honda Masayuki Watanabe Takashi Nagaie | 2007 | World Journal of Gastroenterology2007，13，14： | 34 |
| 5 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 6 | Causal role of Helicobacter pylori infection in gastric cancer显示文摘胃的癌症是在世界,为在亚洲的所有癌症盒子的一个大比例的财务,拉丁美洲,和在欧洲的一些国家上的第二很经常的癌症。Helicobacter pylori (H pylori ) 被认为是在萎缩性胃炎的发展起一个特定的作用,它多代表最公认的小径在走肠类型的胃的致癌作用。最近的研究建议那联合招待基因因素,细菌的毒力因素,并且环境并且生活方式因素决定胃的损坏和 H pylori 感染的最终的临床的结果的严厉。胃的癌症的领先的原因应该导致有效根除策略的 H pylori 的精液的发现。胃的癌症的预防要求更好屏蔽的策略为根除识别候选人。 | Takafumi Ando Yasuyuki Goto Osamu Maeda Osamu Watanabe Kazuhiro Ishiguro Hidemi Goto | 2006 | World Journal of Gastroenterology2006，12，2： | 29 |
| 7 | One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent显示文摘瞄准:为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法,在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法:由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被包括。在这些病人的恶意是很先进的癌或老年的结果。经皮的 transhepatic 胆管造影术在 ultrasonographic 指导下面被执行。在有一个内部金属性的指南的一根导管是先进的进十二指肠以后,一他们被放在胆总管,在一个点之间在到肝的核的 Vater 和入口的乳头状的小突起以外的 1 厘米。在用就一个单身者跨越距离是困难的情况中他们,另外的斯滕特氏印模膏被放。一根排水导管在地方被离开充当一把止血钳子。在胆汁郁积和斯滕特氏印模膏明显的分辨率被证实以后,导管被移开 2 或 3 d 过程以后。结果:EMS 的一步舞插入与 24.4 min 的一过程平均数时间在所有病人被完成。从要求了 2 他们的病人, 4 需要一过程时间超过 30 min。导管的移动的吝啬的时间过程以后是 2.3 d。所有病人与 7.8 瞬间的一吝啬的后续时间死于恶意。没有 stent 相关的复杂并发症或斯滕特氏印模膏阻塞被遇到。结论:他们的一步舞经皮的 transhepatic 插入是为决定胆汁的阻塞和罐头有效地改进病人生命的质量的一个简单过程。 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji Uchida Yasuo Arima Manabu Watanabe Eiichi Uchida Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，15： | 28 |
| 8 | Risk factors for bleeding after endoscopic mucosal resection显示文摘AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of association.RESULTS: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated type.CONCLUSION: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR. | Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa | 2005 | World Journal of Gastroenterology2005，11，46： | 25 |
| 9 | Spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein显示文摘Preservation of the spleen at distal pancreatectomy has recently attracted considerable attention.Since our first successful trial,spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein for tumors of the pancreas and chronic pancreatitis has been performed more frequently.The technique for spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein are outlined.The splenic vein is identified behind the pancreas and within the thin connective tissue membrane.The connective tissue membrane is cut longitudinally above the splenic vein.An important issue is to remove the splenic vein from the body of the pancreas toward the spleen,since a different approach may be very difficult.The pancreas is preferably removed from the splenic artery toward the head of the pancreas itself.This procedure is much easier than removing the pancreas from the vein side.One patient had undergone distal gastrectomy for duodenal ulcer,with reconstruction by Billroth Ⅱ tehcnique.If distal pancreatectomy with splenectomy had been performed for the lesion of the distal pancreas at the time,the residual stomach would also have to be resected.The potential damage done to the patient by reconstruction of the gastrointestinal tract in combination with distal pancreatectomy and splenectomy would have been much greater than with distal pancreatectomy only with preservation of the spleen and residual stomach.Benign lesions as well as low-grade malignancy of the body and tail of the pancreas may be a possible indication for this procedure. | Wataru Kimura Toshiyuki Moriya Jinfeng Ma Yukinori Kamio Toshihiro Watanabe Mitsukiro Yano Hiroto Fujimoto Koji Tezuka Ichiro Hirai Akira Fuse | 2007 | World Journal of Gastroenterology2007，13，10： | 24 |
| 10 | Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein:A New Food Function of Proso Millet显示文摘We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (HDL) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of HDL-cholesterol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol | N. NISHIZAWA S. SHIMANUKI H. FUJIHASHI H. WATANABE Y. FUDAMOTO AND T. NAGASAWA (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research Laboratory,Nitto Best Co., Ltd, Sagae, Yamagata 991 Ka | 1996 | Biomedical and Environmental Sciences1996，9，2： | 24 |
| 11 | Single-incision laparoscopic cholecystectomy:Single institution experience and literature review显示文摘Single-incision laparoscopic surgery is a rapidly evolving field as a bridge between traditional laparoscopic surgery and natural orifice transluminal endoscopic surgery.We report one of the initial clinical experiences in Japan with this new technique.Four cases of gallbladder diseases were selected for this new technique.A single curved intra-umbilical 25-mm incision was made by pulling out the umbilicus.A 12-mm trocar was placed through an open approach,and the abdominal cavity was explored with a 10-mm semiflexible laparoscope.Two 5-mm ports were inserted laterally from the laparoscope port.A 2-mm mini-loop retractor was inserted to retract the fundus of the gallbladder.Dissection was performed using an electric cautery hook and an Endograsper roticulator.There were two women and two men with a mean age of 50.5 years(range:40-61 years).All procedures were completed successfully without any perioperative complications.In all cases,there was no need to extend the skin incision.Average operative time was 88.8 min.Postoperative follow-up didnot reveal any umbili-cal wound complication.Single-incision laparoscopic cholecystectomy is feasible and a promising alternative method as scarless abdominal surgery for the treatment of some patients with gallbladder disease. | Yasumitsu Hirano Toru Watanabe Tsuneyuki Uchida Shuhei Yoshida Kanae Tawaraya Hideaki Kato Osamu Hosokawa | 2010 | World Journal of Gastroenterology2010，16，2： | 23 |
| 12 | Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute pancreatitis of rats显示文摘瞄准:在尖锐胰腺炎(AP ) 调查细胞间的粘附 molecule-1 (ICAM-1 ) 和它的相反的受体 LFA-1 和 Mac-1 的角色。方法:SD 老鼠随机被分配到 AP 组和控制组(25 只老鼠每) 。AP 被 5% chenodeoxycholic 酸的注入导致进胰腺的管,由胰腺的管的结扎列在后面。老鼠在胰腺炎的正式就职以后在 1, 3, 6, 12 和 24 h 被牺牲。五只老鼠同时被牺牲在在从胰和肺的血和标本前的二个组的点被获得。浆液淀粉酶和腹水被测量在每次指。在点被免疫组织化学在胰和肺估计的不同时间的 ICAM-1 的表示,和在不同时间点的 neutrophils 上的 LAF-1 和 Mac-1 的表示被流动血细胞计数器检测。结果:AP 的正式就职被淀粉酶和组织学的研究的浆液层次证实。在在根本,时间削尖的控制组(P<0.05 或 P<0.01 ) 比那显著地增加的胰的 ICAM-1 的表示,以及在除了在 1 h 的肺的表示。在血的 neutrophil 上的 LFA-1 和 Mac-1 的表达式在几个次点(P<0.05 或 P<0.01 ) 在控制组比那在 AP 组显著地增加了。腹水的数量和 AP 组的浆液淀粉酶水平比根本,时间削尖的控制组(P<0.05 或 P<0.01 ) 的显著地增加了。到这些的平行结果,重要嗜中性的渗入在胰被发现, AP 的肺纸巾组织老鼠。结论:我们的调查结果在调停为 ICAM-1, LFA-1 和 Mac-1 建议重要角色到全身的病的从局部病的 AP 的发展。ICAM-1, LFA-1, Mac-1 和随后的白血球渗入的 Upregulation 看起来是在 AP 的胰腺、肺的损害的重要事件。 | Wei Sun Yasuhiro Watanabe Zhong-Qiu Wang | 2006 | World Journal of Gastroenterology2006，12，31： | 22 |
| 13 | Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation显示文摘AIM To investigate clinicopathological features of early stage gastric cancer with enteroblastic differentiation(GCED).METHODS We retrospectively investigated data on 6 cases of early stage GCED and 186 cases of early stage conventional gastric cancer(CGC: well or moderately differentiated adenocarcinoma) who underwent endoscopic submucosal dissection or endoscopic mucosal resection from September 2011 to February 2015 in our hospital.GCED was defined as a tumor having a primitive intestine-like structure composed of cuboidal or columnar cells with clear cytoplasm and immunohistochemical positivity for either alpha-fetoprotein, Glypican 3 or SALL4. The following were compared between GCED and CGC: age, gender, location and size of tumor, macroscopic type, ulceration, depth of invasion, lymphatic and venous invasion, positive horizontal and vertical margin, curative resection rate.RESULTS Six cases(5 males, 1 female; mean age 75.7 years; 6 lesions) of early gastric cancer with a GCED component and 186 cases(139 males, 47 females; mean age 72.7 years; 209 lesions) of early stage CGC were investigated. Mean tumor diameters were similar but rates of submucosal invasion, lymphatic invasion, venous invasion, and non-curative resection were higher in GCED than CGC(66.6% vs 11.4%, 33.3% vs 2.3%, 66.6% vs 0.4%, 83.3% vs 11% respectively, P < 0.01). Deep submucosal invasion was not revealed endoscopically or by preoperative biopsy. Histologically, in GCED the superficial mucosal layer was covered with a CGC component. The GCED component tended to exist in the deeper part of the mucosa to the submucosa by lymphatic and/or venous invasion, without severe stromal reaction. In addition, Glypican 3 was the most sensitive marker for GCED(positivity, 83.3%), immunohistochemically.CONCLUSION Even in the early stage GCED has high malignant potential, and preoperative diagnosis is considered difficult. Endoscopists and pathologists should know the clinicopathological features of this highly malignant type of cancer. | Kohei Matsumoto Hiroya Ueyama Kenshi Matsumoto Yoichi Akazawa Hiroyuki Komori Tsutomu Takeda Takashi Murakami Daisuke Asaoka Mariko Hojo Natsumi Tomita Akihito Nagahara Yoshiaki Kajiyama Takashi Yao Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，36： | 20 |
| 14 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 15 | Optimal treatment for Siewert type Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction: A retrospective cohort study with long-term follow-up显示文摘AIM To determine the optimal treatment strategy for Siewert type Ⅱ and?Ⅲ?adenocarcinoma of the esophagogastric junction.METHODS We retrospectively reviewed the medical records of 83 patients with Siewert type?Ⅱ?and?Ⅲ?adenocarcinoma of the esophagogastric junction and calculated both an index of estimated benefit from lymph node dissection for each lymph node(LN) station and a lymph node ratio(LNR: ratio of number of positive lymph nodes to the total number of dissected lymph nodes). We used Cox proportional hazard models to clarify independent poor prognostic factors. The median duration of observation was 73 mo.RESULTS Indices of estimated benefit from LN dissection were as follows, in descending order: lymph nodes(LN) along the lesser curvature, 26.5; right paracardial LN, 22.8; left paracardial LN, 11.6; LN along the left gastric artery, 10.6. The 5-year overall survival(OS) rate was 58%. Cox regression analysis revealed that vigorous venous invasion(v2, v3)(HR = 5.99; 95%CI: 1.71-24.90) and LNR of > 0.16(HR = 4.29, 95%CI: 1.79-10.89) were independent poor prognostic factors for OS.CONCLUSION LN along the lesser curvature, right and left paracardial LN, and LN along the left gastric artery should be dissected in patients with Siewert type?Ⅱ?or?Ⅲ?adenoca rcinoma of the esophagogastric junction. Patients with vigorous venous invasion and LNR of > 0.16 should be treated with aggressive adjuvant chemotherapy to improve survival outcomes. | Kei Hosoda Keishi Yamashita Hiromitsu Moriya Hiroaki Mieno Masahiko Watanabe | 2017 | World Journal of Gastroenterology2017，23，15： | 19 |
| 16 | Geochemistry of Rare Earth Elements(REE) in the Weathered Crusts from the Granitic Rocks in Sulawesi Island, Indonesia显示文摘We report for the first time the geochemistry of rare earth elements(REE) in the weathered crusts of I-type and calc-alkaline to high-K(shoshonitic) granitic rocks at Mamasa and Palu region, Sulawesi Island, Indonesia. The weathered crusts can be divided into horizon A(lateritic profile) and B(weathered horizon). Quartz, albite, kaolinite, halloysite and montmorrilonite prevail in the weathered crust. Both weathered profiles show that the total REE increased from the parent rocks to the horizon B but significantly decrease toward the upper part(horizon A). LREE are enriched toward the upper part of the profile as shown by La/YbN value. However, HREE concentrations are high in horizon B1 in Palu profile. The total REE content of the weathered crust are relatively elevated compared to the parent rocks, particularly in the lower part of horizon B in Mamasa profile and in horizon B2 in Palu profile. This suggests that REE-bearing accessory minerals may be resistant against weathering and may remain as residual phase in the weathered crusts. The normalized isocon diagram shows that the mass balance of major and REE components between each horizon in Mamasa and Palu weathering profile are different. The positive Ce anomaly in the horizon A of Mamasa profile indicated that Ce is rapidly precipitated during weathering and retain at the upper soil horizon. | Adi Maulana Kotaro Yonezu Koichiro Watanabe | 2014 | Journal of Earth Science2014，25，3： | 18 |
| 17 | Xanthogranulomatous cholecystitis:Difficulty in differentiating from gallbladder cancer显示文摘AIM: To compare cases of xanthogranulomatous cholecystitis(XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical options.METHODS: From April 2000 to December 2013, 6 XGC patients received extended surgical resections. During the same period, 16 patients were proven to have gallbladder(GB) cancer, according to extended surgical resection. Subjects chosen for analysis in this study were restricted to cases of XGC with indistinct borders with the liver as it is often difficult to distinguish these patients from those with advanced GB cancer. We compared the clinical features and computed tomography findings between XGC and advanced GB cancer. The following clinical features were retrospectively assessed: age, gender, symptoms, and tumor markers. As albumin and the neutrophil/lymphocyte ratio(NLR) are prognostic in several cancers, we compared serum albumin levels and the NLR between the two groups. The computerized tomography findings were used to compare the two diseases, determine the coexistence of gallstones, the pattern of GB thickening(focal or diffuse), the presence of a hypoattenuated intramural nodule, and continuity of the mucosal line.RESULTS: Based on the preoperative image findings, we suspected GB carcinoma in all cases includingXGC in this series. In addition, by pathological examination, we found that the group of patients with XGC developed inflammatory disease after surgery. Patients with XGC tended to have abdominal pain(4/6, 67%). However, there was no significant difference in clinical symptoms, including fever, between the two groups. Serum albumin and NLR were also similar in the two groups. Serum tumor markers, such as carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9), tended to increase in patients with GB cancer. However, no significant differences in tumor markers were identified. On the other hand, gallstones were more frequently observed in patients with XGC(5/6, 83%) than in patients with GB cancer(4/16, 33%)(P = 0.0116). A hypoattenuated intramural nodule was found in 3 patients with XGC(3/6, 50%), but in only 1 patient with GB cancer(1/16, 6%)(P = 0.0024). The GB thickness, continuous mucosal line, and bile duct dilatation showed no significant differences between XGC and GB cancer.CONCLUSION: Although XGC is often difficult to differentiate from GB carcinoma, it is possible to obtain an accurate diagnosis by careful intraoperative gross observation, and several intraoperative frozen sections. | Hideki Suzuki Satoshi Wada Kenichiro Araki Norio Kubo Akira Watanabe Mariko Tsukagoshi Hiroyuki Kuwano | 2015 | World Journal of Gastroenterology2015，21，35： | 18 |
| 18 | Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization显示文摘AIM: To determine the role of interleukin (IL)-17 in gastric ulcerogenesis. METHODS: Thirty-six gastric ulcer (GU) patients and 29 non-ulcer (NU) patients were enrolled in this study. Mucosal biopsy samples were obtained from the gastric antrum and GU site during endoscopy. Samples were used in in situ stimulation for 48 h in the presence of 10 μg/mL phytohemagglutinin-P (PHA), histological examination, and Helicobacter pylori(H pylori) culture. IL-17 and IL-8 protein levels in culture supernatants were assayed by ELISA. IL-17 mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). H pylori cagA and vacA status was assessed by reverse hybridization using a line probe assay (LiPA). IL-8 levels in culture supernatants were assayed after AGS cells were co-cultured with H pylori strain 26 695 or recombinant human (rh) IL-17. RESULTS: All 36 GU patients and 15 of 29 NU patients were found to be H pylori-positive, while 14 NU patients were H pylori-negative. All 51 H pylori strains from both GU and NU patients were cagA- and vacAs1/m1-positive. Antral mucosal tissues from H pylori-positive patients contained significantly (H pylori-positive NU patients: median 467 pg/mg/protein, range 53-2 499; H pylori-negative NU patients: median 104 pg/mg/protein, range 16-312, P<0.0005) higher levels of IL-17 than those from uninfected patients. IL-17 levels at the ulcer site were significantly (ulcer site: median 1356 pg/mg/protein, range 121-1 3730; antrum: median 761 pg/mg/protein, range 24-7 620, P<0.005) higher than those at distant sites in the antrum. Biopsies from H pylori-positive GU and NU patients showed IL-17 mRNA expression in all samples whereas those from the antrum of the H pylori-negative controls showed no detectable expression. A significant correlation was seen between IL-17 and IL-8 levels at each biopsy site (ulcer: r= 0.62, P<0.0001; antrum: r = 0.61, P<0.0001) in GU patients. RhIL-17 and H pylori strain 26 695 each stimulated IL-8 production from AGS cells. CONCLUSION: IL-17 may play an important role in the inflammatory response to H pylori colonization, and may ultimately influence the outcome of H pylori-associated diseases that arise within the context of gastritis. | Tomokazu Mizuno Takafumi Ando Kazuo Nobata Tomoyuki Tsuzuki Osamu Maeda Osamu Watanabe Masaaki Minami Kenji Ina Kazuo Kusugami Richard M. Peek Hidemi Goto | 2005 | World Journal of Gastroenterology2005，11，40： | 18 |
| 19 | Performance Test and Flow Measurement of Contra-Rotating Axial Flow Pump显示文摘contra-rotating 转子的一个应用程序对对开发更高特定的速度的一个要求被建议了轴的流动泵。在现在的纸,使用 contra-rotating 转子的优点和劣势与转子定子的常规类型比较被描述,基于理论、试验性的调查。优点如下:(1 ) 泵内在地作为更小被设计缩放并且以更低的旋转速度。(2 ) 为有否定斜坡的流动率的一条稳定的头特征曲线出现。(3 ) 作为后面的转子,旋转速度作为前面转子的独立控制被改变,高效操作的更宽的范围被后面的转子速度控制除了前面转子速度控制获得。劣势如下:(1 ) 两倍柄系统的结构变得复杂。(2 ) 泵表演是劣等的在在是的流动率上,装载的后面的转子被削弱。(3 ) 片更强烈从后面的转子划相互作用到前面转子出现。当时,后面的转子设计是一把钥匙完成更高的泵性能。克服这些劣势的一些方法将向 contra-rotating 的更宽的用法更详细地被讨论各种各样的工业地里的轴的流动泵。 | Akinori Furukawa Toru Shigemitsu Satoshi Watanabe | 2007 | Journal of Thermal Science2007，16，1： | 18 |
| 20 | Predictive findings forHelicobacter pylori-uninfected, -infected and -eradicated gastric mucosa: Validation study显示文摘AIM:To validate the usefulness of screening endoscopy findings for predictingHelicobacter pylori (H. pylori) infection status. METHODS:H. pylori infection status was determined by histology, serology, and the urea breast test in 77 consecutive patients who underwent upper endoscopy. Based on the findings, patients were categorized as H. pylori -uninfected, -infected, or -eradicated cases. Using six photos of certain sites in the stomach per case, we determined the presence or absence of the following endoscopic findings:regular arrangement of collecting venules (RAC), linear erythema, hemorrhage, fundic gland polyp (FGP), atrophic change, rugal hyperplasia, edema, spotty erythema, exudate, xanthoma, and mottled patchy erythema (MPE). The diagnostic odds ratio (DOR) and inter-observer agreement (Kappa value) for these 11 endoscopic findings used in the determination of H. pylori infection status were calculated. RESULTS:Of the 77 patients [32 men and 45 women; mean age (SD), 39.7 (13.4) years] assessed, 28 were H. pylori uninfected, 28 were infected, and 21 were eradicated. DOR values were significantly high (< 0.05) for the following H. pylori cases:uninfected cases with RAC (11.5), linear erythema (24.5), hemorrhage (4.1), and FGP (34.5); for infected cases with atrophic change (8.67), rugal hyperplasia (15.8), edema (14.2), spotty erythema (11.5), and exudate (3.52); and for eradicated cases with atrophic change (32.4) and MPE (103.0). Kappa values were excellent for FGP (0.93), good for RAC (0.63), hemorrhage (0.79), atrophic change (0.74), and MPE (0.75), moderate for linear erythema (0.51), rugal hyperplasia (0.49), edema (0.58), spotty erythema (0.47), and exudate (0.46), and poor for xanthoma (0.19). CONCLUSION:The endoscopic findings of RAC, hemorrhage, FGP, atrophic change, and MPE will be useful for predicting H. pylori infection status. | Kazuhiro Watanabe Naoyoshi Nagata Ryo Nakashima Etsuko Furuhata Takuro Shimbo Masao Kobayakawa Toshiyuki Sakurai Koh Imbe Ryota Niikura Chizu Yokoi Junichi Akiyama Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，27： | 17 |
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