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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer显示文摘 | Mok T S Wu Y L Yu C J | 2009 | J ClinOneol2009，27，30： | 1 |
| 3 | Decomposition of volatile organic compounds and nitric oxide by non thermal plasma discharge process显示文摘 | Mok Y S Nam C M Cho M H | 2002 | IEEE Transaction on Plasma Science2002，30，1： | 1 |
| 4 | Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma显示文摘 | MOK T S WU Y L THONGPRASERT S | 2009 | N Engl J Med2009，361，10： | 1 |
| 5 | Flue gas treatment using pulsed corona discharge generated by magnetic pulse compression modulator 显示文摘 | MOK Y S LEE H W HYUN Y J | 2001 | Journal of Electrostatics2001，53，3： | 1 |
| 6 | Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma显示文摘 | Mok T S Wu Y L Thongprasert S | 2009 | N Engl J Med2009，361，10： | 1 |
| 7 | A new simulation model of PMSM motor with real back EMF waveform显示文摘 | | 2000 | Proceeding from Computers in Power Electronics2000，，1618： | 1 |
| 8 | Conversion of NO to NO2 in air by a pulsed corona discharge process显示文摘 | Ham S W | 1998 | Chemical Engineering Science1998，53，9： | 1 |
| 9 | New criterion for internal crack fomlation in continuously cast steels显示文摘 | Mok W Y Jung Y T Jin S D | 2000 | Metallurgical and Materials Transactions B2000，31，8： | 1 |
| 10 | Prospectively versus retro- spectively ECG-gated 256-slice CT angiography to assess coro- nary artery bypass gralts comparison of image quality and radia- tion dose显示文摘 | Lee Y W Yang C C Mok G S | 2012 | PLoS one2012，7，49： | 1 |
| 11 | Gefitinib or carboplatin --paclitaxel in pulmonary adenocarcinoma显示文摘 | Mok T S Wu Y L Thongprasert S | 2009 | N Engl J Med2009，361，10： | 1 |
| 12 | Numerical and experimental analysis of penetration grouting in jointed rock masses显示文摘 | LEE J S BANG C S MOK Y J | 2000 | International Journal of Rock Mechanics & Mining Sciences2000，37，： | 1 |
| 13 | A new simulation model of PMSM motor with real back EMF wave form显示文摘 | Jeon Y S Mok H S Choe ET | 2000 | Proceeding from Computers in Power Electronics2000，，1618： | 1 |
| 14 | Absorption - reduction Technique Assisted by Ozone Injec-tion and Sodium Sulfide for NOx Removal from Exhaust Gas 显示文摘 | Mok Y S | 2006 | Chemical Engineering Journal2006，118，12： | 1 |
| 15 | 查看详情显示文摘 | Mok Y S Jo J O | | 0，，： | 1 |
| 16 | Phase Ⅲ randomized open-label first-line study of gefitinib versus carboplatin /paclitaxel in clinically selected patients with advanced non-small-cell lung cancer (IPASS)显示文摘 | Mok T Wu Y L Thongprasent S | 2008 | Ann Oncol2008，19，： | 1 |
| 17 | Numerical and Experimental Analysis of Penetration Grouting in Jointed Rock Masses显示文摘 | Lee J S Bang C S Mok Y J | 2000 | International Journal of Rock Mechanics & Mining Sciences2000，37，： | 1 |
| 18 | Positive pulsed corona discharge process for simultaneous removal of SO2 and NO from iron-ore sintering flue gas显示文摘 | Mok Y S Nam I S | 1999 | IEEE Trans on Plasma Sci1999，27，4： | 1 |
| 19 | De composition of hydrofluorocarbons in a dielectric- packed plasma reactor显示文摘 | MOK Y S DEMIDYUK V WHITEHEAD J C | 2008 | Journal of Physical Chemis- try A2008，112，29： | 1 |
| 20 | Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma显示文摘 | Mok T S Wu Y L Thongprasert S | | 0，，10： | 1 |
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