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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Identification of novel soybean microRNAs involved in abiotic and biotic stresses 显示文摘 | Kulcheski F R de Oliveira L F Molina L G | 2011 | BMC Genomics2011，12，： | 1 |
| 3 | Hydroconversion of heptane over a Colombian montmorillonite modified with mixed pillars of Al Zr and Al-Si显示文摘 | Molina M F Molina R Moreno S | 2005 | Catalysis Today2005，，： | 1 |
| 4 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 5 | Mineralization of phenol by a heterogeneous uhrasound/Fe-SBA-15/H2O2 process: Multivariate study by factorial design of experiments显示文摘 | Molina R Martinez F Melero J A | 2006 | Appl Catal B: Environ2006，，66： | 1 |
| 6 | Tumor markers in response monitoring and prognosis of non small cell lung cancer:preliminary report显示文摘 | Vinolas N Molina R Galan M C Casas F Callejas M A Filella X | 1998 | Anticancer Res1998，18，1： | 1 |
| 7 | Clinical evaluation of the simultaneous determination of tumor markers in fluid and serum and their ratio in the differential diagnosis of serous effusions显示文摘 | Trapé J Molina R Sant F | 2004 | Tumour Biol2004，25，56： | 1 |
| 8 | Detection of oecult liver metastases in Colorectal cancer by measurement of biliary carcinoembryonic antigen显示文摘 | Novell F Trias LM Molina R | 1997 | Anticancer Res1997，17，4： | 1 |
| 9 | 2011, Ploidy manipulation and polyploid de- tection in the white shrimp Litopenaeus vannamei (Boone 1931 ) ( Decapoda, Penaeidae ) 显示文摘 | Aloise D A Maia-Lima Fde A de Oliveira R M Cabral Tde M Molina W F | 2011 | Marine Biotechnology2011，13，1： | 1 |
| 10 | Effect of Different Non-ionic Surfactants on the Biodegradation of PAHs by Diverse Aerobic Bacteria显示文摘 | Bautista L F Sanz R Molina M C | 2009 | lnt Biodeterior Biodegrad2009，63，7： | 1 |
| 11 | Identification of novel soybean microRNAs involved in abiotic and biotic stresses显示文摘 | Kulcheski F R de Oliveira L F Molina L G | 2011 | BMC Genomics2011，12，： | 1 |
| 12 | Mineralization of phenol by aheterogeneous ultrasound/Fe-SBA-15/H2O2process:Multivariate study by factorial design of experiments显示文摘 | MOLINA R MARTINEZ F MELERO J A | 2006 | Appl Catal B2006，66，： | 1 |
| 13 | Shrink-resistance and wetting properties of keratin fibers treated by glow discharge显示文摘 | Molina R Comelles F Bertran E | 2002 | Journal of Adhesion Science & Technology2002，16，11： | 1 |
| 14 | Pollen production in anemophilous trees显示文摘 | Tormo Molina R Munoz Rodriguez A Silva Palacios I Gallardo Lopez F | | 0，，： | 1 |
| 15 | Zooplanktophagy in the natural diet and selectivity of the invasive mollusk Limnopema fortunei显示文摘 | MOLINA F R DEVERCELLI M | 2010 | Biol Invasions2010，，12： | 1 |
| 16 | Clinical evaluation of the simultaneous determination of tumor markers in fluid and serum and their ratio in the differential diagnosis of serious effusions显示文摘 | Trape J Molina R Sant F | 2004 | Tumor Biol2004，25，56： | 1 |
| 17 | Clinical evaluation of the simultaneous determination of tumor markers in fluid and serum and their ratio in the differential diagnosis of serous effusions显示文摘 | Trape J Molina R Sant F | 2004 | Tumour Biol2004，25，56： | 1 |
| 18 | Best-possible bounds on sets of bivariate distribution functions显示文摘 | Nelsen R B Quesada Molina J J Rodríguez Lallena J A (U)beda F M | | 0，，： | 1 |
| 19 | Clinical valuation of the simultaneous determination of tumor markers in fluid and serum and their ratio in the differential diagnosis of serour effusions显示文摘 | Trape J Molina R Sant F | 2004 | Tumor Biol2004，25，526： | 1 |
| 20 | Clinical evaluation of the simultaneous determination of tumor markers in fluid and serum and their ratio in the differential diagnosis of serous effusions显示文摘 | Trape J Molina R Sant F | 2004 | Turnout Biol2004，25，56： | 1 |
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