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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Activity of antioxidant en-zymes in response to cadmium in Crotalaria juncea显示文摘 | Pereira G J G Molina S M G Lea P J | 2002 | Plant andSoil2002，239，： | 1 |
| 3 | Activity of antioxidant enzymes in response to cadmium in Crotalariajuncea显示文摘 | PEREIRA G J G MOLINA S M G LEA P J | 2002 | Plant and Soil2002，，239： | 1 |
| 4 | Scale-up of tubu- lar photobioreactors 显示文摘 | Molina E M Fernandez F G Camacho F G | 2000 | J Appl Phycol2000，12，3： | 1 |
| 5 | A prospective trial of sustained-release bupropion for depression in HIV-seropositive and AIDS patients 显示文摘 | CURRIER MB MOLINA G KATO M | 2003 | Psychosomatics2003，44，2： | 1 |
| 6 | A destination-branding model:An empirical analysis based on stakeholders显示文摘 | Garcia J.A G(o)mez M Molina A | | 0，，： | 1 |
| 7 | Review of 64 cases of death in children with Prader-Willi syndrome (PWS) 显示文摘 | Tauber M Diene G Molinas C | 2008 | Am J Med Genet A2008，146，7： | 1 |
| 8 | Systemic acquired resistance显示文摘 | RYALS J A NEUENSCHWANDER U H WILLITS M G MOLINA A STEINER H-Y HUNT M D | 1996 | The Plant Cell1996，8，： | 1 |
| 9 | The incidence of main pancreatic duct disruption in severe biliary pancreatitis显示文摘 | Uomo G Molina D Viscoriti M | 1998 | Am J Surg1998，176，： | 1 |
| 10 | Design of in-novative power conditioning system for the grid integra-tion of thermoelectric generators显示文摘 | Molina M G Juanico L E Rinalde G F | | 0，，13： | 1 |
| 11 | Docosahexaenoic acid signalolipidomics in nutrition:significance in aging,neuroinflammation,macular degeneration,Alzheimer's,and other neurodegenerative diseases显示文摘 | Bazan N G Molina M F Gordon W C | 2011 | Annu Rev Nutr2011，31，： | 1 |
| 12 | Mycorrhizal fungi associated with Festuca in the western United States and Canada显示文摘 | Molina R J Trappe J M Strickler G S | 1978 | Canadian Journal of Botany1978，56，： | 1 |
| 13 | Steam gasification of coal at low-medium (600 ℃ 800 ℃ ) temperature with simultaneous CO2 capture in fluidized bed at atmospheric pressure: The effect of inorganic species: 1 Literature review and comments显示文摘 | CORELLA J TOLEDO J M MOLINA G | 2006 | Ind Eng Chem Res2006，45，18： | 1 |
| 14 | Degradation ofchlorophenols by means of advanced oxidation processes:a general review显示文摘 | Pera-Titus M Molina V G Baeos M A | | 0，，： | 1 |
| 15 | Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer显示文摘 | Allred D C Clark G M Molina R | 1992 | Hum Pathol1992，23，9： | 1 |
| 16 | miR 29b and miR-125a regulate podoplanin and suppress invasion in glioblastomap显示文摘 | Cortez M A Nicoloso M S Shimizu M Rossi S Gopisetty G Molina J R | 2010 | Genes Chromosomes Cancer2010，49，： | 1 |
| 17 | Improving the in- tegration of wind power generation into AC microgrids using fly- wheel energy storage 显示文摘 | SUVIRE G O MOLINA M G MERCADO P E | 2012 | IEEE Transactions on Smart Grid2012，3，4： | 1 |
| 18 | A rapid field procedure for screening trace elements in polluted soil using portable X ray fluorescence (PXRF)显示文摘 | Peinado F M Ruano S M Gonzalez M G B Molina C E | 2010 | Geoderma2010，159，： | 1 |
| 19 | Activity of anfioxidant enzymes in response to cadmium in Crotalariajuncea显示文摘 | Pereira G J G Molina S M G Lea P J | 2002 | Plant Soil2002，239，： | 1 |
| 20 | Power flow stabilization and con- trol of microgrid with wind generation by superconducting magnetic energy storage 显示文摘 | MOLINA M G MERCADO P E | 2011 | IEEE Transactions on Power Electronics2011，26，3： | 1 |
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