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| 1 | Advances in diagnosis,treatment and palliation of cholangiocarcinoma:1990-2009显示文摘Several advances in diagnosis,treatment and palliation of cholangiocarcinoma(CC)have occurred in the last decades.A multidisciplinary approach to this disease is therefore recommended.CC is a relatively rare tumor and the main risk factors are:chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree.While the incidence of intra-hepatic CC is increasing,the incidence of extra-hepatic CC is trending down.The only curative treatment for CC is surgical resection with negative margins.Liver transplantation has been proposed only for selected patients with hilar CC that cannot be resected who have no metastatic disease after a period of neoadjuvant chemo-radiation therapy.Magnetic resonance imaging/magnetic resonance cholangiopancreatography,positron emission tomography scan,endoscopic ultrasound and computed tomography scans are the most frequently used modalities for diagnosis and tumor staging.Adjuvant therapy,palliative chemotherapy and radiotherapy have been relatively ineffective for inoperable CC.For most of these patients biliary stenting provides effective palliation.Photodynamic therapy is an emerging palliative treatment that seems to provide pain relief,improve biliary patency and increase survival. The clinical utility of other emerging therapies such as transarterial chemoembolization,hepatic arterial chemoinfusion and high intensity intraductal ultrasound needs further study. | Murad Aljiffry Mark J Walsh Michele Molinari | 2009 | World Journal of Gastroenterology2009，15，34： | 82 |
| 2 | Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010显示文摘Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic. | Chakshu Sharma Karim M Eltawil Paul D Renfrew Mark J Walsh Michele Molinari | 2011 | World Journal of Gastroenterology2011，17，7： | 28 |
| 3 | Discrimination between active and inactive neurocysticercosis by metacestode excretory/secretory antigens of Taenia solium in an enzymelinked immunosorbent assay 显示文摘 | Molinari J L Garc i a-Mendoza E de la Garza Y | 2002 | Am J Trop Med Hyg2002，66，6： | 1 |
| 4 | Role of tryptase in immediate cutaneous responses in allergic sheep显示文摘 | Moore WR Clark J | 1995 | J Appl Physiol1995，79，： | 1 |
| 5 | Correlation betweenmotor performance and cognitive functions in childrenborn<1250g at school age显示文摘 | Seitz J Jenni OG Molinari L | 2006 | Neuropediatrics2006，37，1： | 1 |
| 6 | Influence of the meso-structure in dynamic fracture simulation of concrete under tensile loading显示文摘 | Snozzi L Caballero A Molinari J F | 2011 | Cement and Concrete Research2011，41，11： | 1 |
| 7 | Are 2 cages needed with instrumented PLIF?a comparison of 1 versus 2 interbody cages in a military population显示文摘 | Molinari RW Sloboda J Johnstone FL | 2003 | Am J Orthop2003，32，7： | 1 |
| 8 | Finite element modeling of elasto-plastic contact between rough surfaces 显示文摘 | PEI L HYUN S MOLINARI J F | 2005 | Journal of the Mechanics and Physics of Solids2005，53，11： | 1 |
| 9 | Effect of advancedglycation endproducts on gene expression profiles of humandermal fibroblasts显示文摘 | Molinari J Ruszova E Velebny V | 2008 | Biogerontology2008，9，3： | 1 |
| 10 | A new methodology for ranking sci- entific institutions 显示文摘 | Molinari J F Molinari A | 2008 | Scientometrics2008，75，1： | 1 |
| 11 | Mathematical aspects of a new criterion for ranking scientific institutions based on the h-index显示文摘 | MOLINARI A MOLINARI J F | 2008 | Scientometrics2008，75，2： | 1 |
| 12 | Role of tryptase in immediate cutaneous responses in allergic sheep显示文摘 | Moore WR Clark J | 1995 | J Appl Physiol1995，79，： | 1 |
| 13 | A critique of Bulla's paper on diversity indicies 显示文摘 | Molinari J | 1996 | Oikos1996，76，： | 1 |
| 14 | Intima-Media Thickness: Setting a Standard for a Completely Automated Method of Ultrasound Measure- ment显示文摘 | Molinari F Zeng G Snri J S | 2010 | Ultrasonics Ferroelectrics and Frequency Control IEEE Transactions on2010，57，5： | 1 |
| 15 | Finite element simulation of shaped char- ges显示文摘 | J F Molinari | 2002 | Finite Elements in Analysis and Design2002，38，10： | 1 |
| 16 | A new methodology for rank- ing scientific institutions 显示文摘 | MOLINARI J F MOLINARI A | 2008 | Scientometrics2008，75，1： | 1 |
| 17 | Multiscale modeling of two-dimensional contacts显示文摘 | LUAN B Q HYUN S MOLINARI J F | 2006 | Physical Review E2006，74，04： | 1 |
| 18 | The effects of vertical wind shear on the distribution of convection in tropical cyclones显示文摘 | CORBOSIERO K L MOLINARI J | 2002 | Mon Wea Rev2002，130，8： | 1 |
| 19 | Liq- uid phase sintering of a boron alloyed austenitic stain- less steel 显示文摘 | MOLINARI A MENAPACE C KAZIOR J | 2007 | Materials Science Forum2007，，： | 1 |
| 20 | Are 2 cages needed with instrumented PLIF?A comparison of 1 versus 2 interbody cages in a military population 显示文摘 | Molinari RW Sloboda J Johnstone FL | 2003 | Am J Orthop (Belle Mead NJ)2003，32，43： | 1 |
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