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| 1 | Identification of a new natural Ara h 6 isoform and of its proteolytic product as major allergens in peanut显示文摘 | BERNARD H MONDOULET L DRUMARE M F | 2007 | J Agric Food Chore2007，55，： | 1 |
| 2 | Influence of thermal processing on the allergenicity of peanut proteins显示文摘 | MONDOULET L PATY E DRUMARE M F | | 0，，11： | 1 |
| 3 | Identification of a new natural Ara h 6 isoform and of its proteolyticproduct as major allergens in peanut显示文摘 | BERNARD H MONDOULET L DRUMARE M F | 2007 | J Agric Food Chem2007，55，： | 1 |
| 4 | Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy显示文摘 | Mondoulet L Dioszeghy V Ligouis M | 2010 | Clin Exp Allergy2010，40，4： | 1 |
| 5 | picutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts显示文摘 | Mondoulet L Dioszeghy V Vanoirbeek JA | | 0，，： | 1 |
| 6 | Influence of thermal processing on the allergenicity of peanut proteins 显示文摘 | Mondoulet L Paty E Drumare M F | 2005 | Journal of agricultural and food chemistry2005，53，11： | 1 |
| 7 | Influ- ence of thermal processing on the allergenicity of peanut proteins显示文摘 | MONDOULET L PATY E DRUMARE M F | 2005 | J Agric Food Chem2005，53，： | 1 |
| 8 | Differences in phenotype,homing properties and suppressive activities of regulatory T cells induced by epicutaneous,oral or sublingual immunotherapy in mice sensitized to peanut显示文摘Allergen-specific immunotherapy has been proposed as an attractive strategy to actively treat food allergy using the following three different immunotherapy routes:oral(OIT),sublingual(SLIT)and epicutaneous(EPIT)immunotherapy.Regulatory T cells(Tregs)have been shown to have a pivotal role in the mechanisms of immunotherapy.The aim of this study was to compare the phenotype and function of Tregs induced in peanut-sensitized BALB/c mice using these three routes of treatment.We show that although EPIT,OIT and SLIT were all able to effectively desensitize peanut-sensitized mice,they induced different subsets of Tregs.Foxp3+Tregs were induced by the three treatment routes but with greater numbers induced by EPIT.EPIT and OIT also increased the level of LAP+Tregs,whereas SLIT induced IL-10+cells.The suppressive activity of EPIT-induced Tregs did not depend on IL-10 but required CTLA-4,whereas OIT acted through both mechanisms and SLIT was strictly dependent on IL-10.Moreover,the three routes influenced the homing properties of induced Tregs differently,with a larger repertoire of chemokine receptors expressed by EPIT-induced Tregs compared with OIT-and SLIT-induced cells,resulting in different protective consequences against allergen exposure.Furthermore,whereas OIT-or SLIT-induced Tregs lost their suppressive activities after treatment was discontinued,the suppressive activities of EPIT-induced Tregs were still effective 8 weeks after the end of treatment,suggesting the induction of a more long-lasting tolerance.In summary,EPIT,OIT and SLIT mediated desensitization through the induction of different subsets of Tregs,leading to important differences in the subsequent protection against allergen exposure and the possible induction of tolerance. | Vincent Dioszeghy Lucie Mondoulet Emilie Puteaux Véronique Dhelft Mélanie Ligouis Camille Plaquet Christophe Dupont Pierre-Henri Benhamou | 2017 | Cellular & Molecular Immunology2017，14，9： | 1 |
| 9 | Influence of Thermal Processing on the Allergenicity of Peanut Proteins显示文摘 | Mondoulet L Paty E Drumaro MF | | 0，，11： | 1 |
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