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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Rates and risk factors for suicidal ideation,suicide attempts and suicide deaths in persons with HIV:a systematic review and meta-analysis显示文摘Background People living with HIV/AIDS(PLWHA)must contend with a significant burden of disease.However,current studies of this demographic have yielded wide variations in the incidence of suicidality(defined as suicidal ideation,suicide attempt and suicide deaths).Aims This systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in PLWHA.Methods Publications were identified from PubMed(MEDLINE),SCOPUS,OVID(MEDLINE),Joanna Briggs Institute EBP and Cochrane Library databases(from inception to before 1 February 2020).The search strategy included a combination of Medical Subject Headings associated with suicide and HIV.Researchers independently screened records,extracted outcome measures and assessed study quality.Data were pooled using a random-effects model.Subgroup and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of heterogeneity.Main outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide attempt.Results A total of 185199 PLWHA were identified from 40 studies(12 cohorts,27 cross-sectional and 1 nested case-control).The overall incidence of suicide completion in PLWHA was 10.2/1000 persons(95%CI:4.5 to 23.1),translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 persons.The lifetime prevalence of suicide attempts was 158.3/1000 persons(95%CI:106.9 to 228.2)and of suicidal ideation was 228.3/1000 persons(95%CI:150.8 to 330.1).Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease(AIDS),the risk of suicide completion increased by 34 per 1000 persons.The quality of evidence by Grading of Recommendations,Assessment,Development and Evaluations for the suicide deaths was graded as‘moderate’quality.Conclusions The risk of suicide death is 100-fold higher in people living with HIV than in the general population.Lifetime incidence of suicidal ideation and attempts are substantially high.Suicide risk assessments should be a priority in PLWHA,especially for those with more advanced disease. | Matt Pelton Matt Ciarletta Holly Wisnousky Nicholas Lazzara Monica Manglani Djibril M Ba Vernon M Chinchillli Ping Du Anna E Ssentongo Paddy Ssentongo | 2021 | General Psychiatry2021，34，2： | 3 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 5 | Mixed-genome microarrays reveal multiple serotype and LineageSpecific Differences among Strains of Listeria monocytogene 显示文摘 | DOUGLAS R CALL MONICA K BORUCKI THOMAS E BESSER | 2003 | J Clin Microbiol2003，41，2： | 1 |
| 6 | Study on the selectivity of bleaching with oxygen-containing species 显示文摘 | MONICA E K GIERER J JANSBO K | 1989 | Holzforschung1989，43，： | 1 |
| 7 | Effects of endurance exercise training on heart rate variability and susceptibility to sudden cardiac death:protection is not due to enhanced cardiac vagal regulation显示文摘 | George E Billman Monica Kukielka | 2006 | J Appl Physiol2006，100，： | 1 |
| 8 | Biosynthesis and biochemical properties of the hepatitis C virus core protein显示文摘 | Santolini E Migliaccio G La Monica N | 1994 | J Virol1994，68，： | 1 |
| 9 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Monica L E Elizabeth A D J William E B J | 2001 | Pest Manag sc2001，57，8： | 1 |
| 10 | Cytochrome P4501A1, cigarette smoking, and risk of endometrial cancer (United States) 显示文摘 | Monica McGrath Susan E Hankinson | 2007 | Cancer Causes Control2007，18，： | 1 |
| 11 | Evaluation of nursing students' work technique after proficiency training in patient transfer methods during undergraduate education显示文摘 | Christina E Johnsson A Monica AK | 2006 | Nurse Education Today2006，，4： | 1 |
| 12 | A diverse family of phenylalanine ammonia-lyase genes expressed in pine trees and cell cultures显示文摘 | Stefanie L B Monica L C Brian E E | 1998 | Plant Molecular Biology1998，37，1： | 1 |
| 13 | Optimum voltage control for loss minimization in HVDC multi- terminal transmission systems for large offshore wind farms显示文摘 | Monica A P Agusti E A Oriol G B | 2012 | Electric Power Systems Research2012，，89： | 1 |
| 14 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Monica L E Elizabeth A D J William E B J | | 0，，8： | 1 |
| 15 | Fast STIR whole-body MR imaging in children显示文摘 | Christian JK Monica E Stephn FM | 2004 | Radiology2004，24，： | 1 |
| 16 | Synthesis of potentially anti - inflammatory IPL576,092 - contignasterol and IPL576092 - manoalide hydrids 显示文摘 | IZZO I AVALLONE E MONICA C D | 2004 | Tetrahedron2004，60，： | 1 |
| 17 | Anthocyanin pigment composition of red-fleshed potatoes显示文摘 | LUIS E RODRIGNEZ-SAONA M MONICA G | 1998 | J Food Sci1998，63，3： | 1 |
| 18 | Evaluating high- fidelity human simulators and standardized patients in an undergraduate nursing health assessment course 显示文摘 | Marian E Barbara W Monica L | 2012 | Nurs Edu Today2012，32，4： | 1 |
| 19 | Periorbital skin tightening with a broadband infrared device: Preliminary study resuhs显示文摘 | Monica E | 2010 | J Cosmet Laser Ther2010，12，1： | 1 |
| 20 | Inflammatory response : pathway across he blood brain barrier显示文摘 | MONICA E K ENGBLOM D SAHA S | 2001 | Nature2001，410，6827： | 1 |
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