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| 1 | Thalidomide induces mucosal healing in Crohn's disease: Case report显示文摘Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract that is defi ned by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn's disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn's disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximabafter three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response. | Márcio Rios Leite Sandra Sousa Santos André Castro Lyra Jaciane Mota Genoile Oliveira Santana | 2011 | World Journal of Gastroenterology2011，17，45： | 9 |
| 2 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 3 | Finite element dynamic analysis of practical disc 显示文摘 | Mota Soares C A Petyt M | 1978 | J Sound Vibr1978，61，： | 2 |
| 4 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 5 | Studies on the properties of Celluclast/Eudragit L-100 conjugate显示文摘 | Dourado F M Bastos M Mota | 2002 | Journal of Biotechnology2002，99，： | 1 |
| 6 | Genetic polymorphism,medical therapy and sequential cardiac function in patients with heart failure显示文摘 | CUOCO M A PEREIRA A C MOTA GDE F | 2008 | Arq Bras Cardiol2008，90，： | 1 |
| 7 | Improvement for Mass-exchange Networkr Design显示文摘 | Castro P Motas H Femandes M C | 1999 | Chemical Engineering Science1999，54，11： | 1 |
| 8 | Optimal design for active damping in sandwich structures using the Direct MultiSearch method 显示文摘 | Araujo A L Madeira J F A Mota Soares C M | 2013 | Composite Structures2013，105，： | 1 |
| 9 | Fed- batch cultivation of Saccharomyces cerevisiae in a hyperbaric bioreactor 显示文摘 | Belo I Pinheiro R Mota M | 2003 | Biotechnology Progress2003，19，2： | 1 |
| 10 | Preferential ammonium uptake during growth cycle and identification of ammonium transporter genes in young pear trees 显示文摘 | Mota M Neto C B Monteiro A A | 2011 | Journal of Plant Nutrition2011，34，6： | 1 |
| 11 | Must deacidification with an induced flocculant yeast strain of Schizosaccharomyces pombe显示文摘 | SOUSA MJ TEIXEIRA JA MOTA M | | 0，，02： | 1 |
| 12 | Biodegradation of colorants in refinery effluents : potential use of the fungus Phanerochaete chrysosporium显示文摘 | Guimaraes C Bento L S M Mota M | 1999 | International Sugar Journal1999，101，： | 1 |
| 13 | The metabolic syndome-a multifaced disease显示文摘 | Mota M Panus C Mota E | 2004 | Rom J Intern Med2004，42，2： | 1 |
| 14 | Development of a finite element model for the identification of mechanical and piezoelectric properties through gradient optimization and experimental vibration data显示文摘 | Araujo A L Mota Soares C M Herskovits J | 2002 | Composite Structures2002，58，： | 1 |
| 15 | Anti-D alloimmunization by weak D type 1 red blood cells with a very low antigen density显示文摘 | Mota M Fonseca NL Rodrigues A | 2005 | Vox Sang2005，88，： | 1 |
| 16 | Molecular typing of Pyrus based on RAPD markers显示文摘 | Oliveira C M Mota M Monte Corvo L | 1999 | Sci Hort1999，79，： | 1 |
| 17 | The thyroid and autoimmtmity显示文摘 | Lichiardopol C Mota M | 2009 | Rom J Intern Med2009，47，3： | 1 |
| 18 | Induction of protective antibodies against dengue virus by tetravalent DNA immunization of mice with domain Ⅲ of the envelope protein显示文摘 | Mota J Acosta M Argotte R | 2005 | Vaccine2005，23，26： | 1 |
| 19 | A high-resolution time interpolator based on a Delay Locked Loop and an RC delay line显示文摘 | Mota M | 1999 | IEEE Journal of Solid-State Circuits1999，34，10： | 1 |
| 20 | Effect of different toxic compounds on ATP content and acid phosphatase activity in axenic cultures of Tetrahymena pyriformis 显示文摘 | Nicolau A Mota M Lima N | 2004 | Ecotoxicology andEnv#vnmental Safety2004，57，2： | 1 |
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