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| 1 | Treatment of laryngopharyngeal reflux disease: A systematic review显示文摘BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success rate.AIM To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD treatment.METHODS Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of LPRD.Clinical prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed LPRD.The criteria for considering studies for the review were based on the population,intervention,comparison,and outcome framework.RESULTS The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk.The most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor antagonists.CONCLUSION Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux. | Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun Sven Saussez | 2019 | World Journal of Clinical Cases2019，7，19： | 9 |
| 2 | A comparative study of Fas and Fas-ligand expression during melanoma progression显示文摘 | Soubrane C Mouawad R Antoine EC | | 0，，： | 2 |
| 3 | Plasma Tie-2 and its ligand Ang-2 in metastatic malignant melanoma:Relationships to clinicopathological parameters and tumor burden显示文摘 | Mouawad R Thery JC Vignot S | 2011 | J Clin Oncol:2011ASCO Annual Meeting Abstracts Part 12011，29，15： | 1 |
| 4 | Skin Manifestations and vascular endothelial growth factor levels in POEMS syndrome:impact of autologous hematopoietic stem cell transplantation显示文摘 | Barete S Mouawad R Choquet S | | Archives of Dermatology0，，： | 1 |
| 5 | Plasma Fas ligand, an inducer of apoptosis, and plasma solube Fas, an inhibitor of apoptosis, in advanced melanoma 显示文摘 | Mouawad R Khayat D Soubrane C | 2000 | Melanoma Research2000，10，5： | 1 |
| 6 | Treatment for metastatic malignant melanoma: old drugs and new strategies 显示文摘 | Mouawad R Sebert M Michels J | 2010 | Crit Rev Oncol Hematol2010，74，1： | 1 |
| 7 | Serum interleukin-6 concentrations as predictive factor of time to progression in metastatic malignant melanoma treated by biochemotherapy:a retrospective study显示文摘 | Mouawad R Rixe O Meric JB | 2002 | Cytokines Cell Mol Ther2002，7，4： | 1 |
| 8 | Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signalling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells显示文摘 | Mouawad R Li Y Anand-Srivastava MB | 2004 | Mol Pharmacol2004，65，40： | 1 |
| 9 | Actions of HSVtk and connexin43 gene delivery on gap junctional communication and drug sensitization in hepatocellular carcinoma 显示文摘 | Ghoumari AM Mouawad R Zerrouqi A | 1998 | C ene Ther1998，5，8： | 1 |
| 10 | Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptorsis, in advanced melanoma显示文摘 | Mouawad R Khayat D Soubrane C | 2000 | Melanoma Res2000，10，5： | 1 |
| 11 | A comparative study of Fas and Fas-ligand expression during melanoma progression 显示文摘 | Mouawad R Antoine EC | 2000 | Br J Dermatol2000，143，2： | 1 |
| 12 | A star in a 15,2-year orbit around the supermassive black bole at the centre of the Milky Way显示文摘 | Sch(o)del R Ott T Genzel R Hofmann R Lehnert M Eckart A Mouawad N Alexander T Reid M J Lenzen R Hartung M Lacombe F Rouan D Gendron E Rousset G Lagrange A M Brandner W Ageorges N Lidman C Moorwood A F M Spyromilio J Hubin N Menten K M | | 0，，6908： | 1 |
| 13 | Treatment for metastatic malignant melanoma:old drugs and new strategies显示文摘 | Mouawad R Sebert M Michels J | 2010 | Crit Rev Oncol Hematol2010，74，1： | 1 |
| 14 | Treatment for metastatic malignant melanoma:old drugs and new strategies显示文摘 | Mouawad R Sebert M Michels J | 2010 | Crit Rev Oncol Hematol2010，74，1： | 1 |
| 15 | Treatment for metastatic malignant melanoma:Old drugs and new strategies显示文摘 | MOUAWAD R SEBERT M MICHELS J | 2010 | Crit Rev Oncol Hematol2010，74，1： | 1 |
| 16 | Acute gallbladder torsion - a continued pre-operative diagnostic dilemma显示文摘 | Mouawad NJ Crofis B Streu R | 2011 | World J Emerg Surg2011，6，1： | 1 |
| 17 | Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in advanced melanoma 显示文摘 | Mouawad R Khayat D Soubrane C | 2000 | Melanoma Res2000，10，： | 1 |
| 18 | Tumoural ex- pression and circulating level of VEGFR - 3 ( Fit - 4) in metastat- ic melanoma patients: Correlation with clinical parameters and out- come显示文摘 | MOUAWAD R SPANO J P COMPERAT E | 2009 | Eur J Cancer2009，45，8： | 1 |
| 19 | Skin manifestations and vascular endothelial growth factor levels in POEMS syn- drome:impact of autologous hematopoietic stem cell trans- plantation 显示文摘 | Barete S Mouawad R Choquet S | 2010 | Arch Dermato12010，146，6： | 1 |
| 20 | Treatment for metastatic malignant melanoma: old drugs and new strategies显示文摘 | Mouawad R Sebert M Michels J | 2010 | Criti Rev Oncol/Hematol2010，74，1： | 1 |
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