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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Natural killer cells promote long -term hepatobiliary inflammation in a low - dose rotavirus model of experimental biliary atresia 显示文摘 | SQUIRES JE SHIVAKUMAR P MOURYA R | 2015 | PLoS One2015，10，5： | 1 |
| 3 | Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2显示文摘 | Mohanty SK Ivantes CA Mourya R | 2010 | Pediatr Res2010，67，4： | 1 |
| 4 | Behaviour of Steam Generator Bolted Flange Joints at Elevated Temperatures 显示文摘 | Vinod V Mourya R K Sreedhar B K | 2013 | Annals of Nuclear Energy2013，51，30： | 1 |
| 5 | Inhibition of Mild Steel Corrosion in Hydrochloric and Sulfuric Acid Media Using a Thiosemicarbazone Derivative显示文摘 | Mourya P Banerjee S Rastogi R B | 2013 | lnd Eng Chem Res2013，52，12： | 1 |
| 6 | Primary mediastinal large B-cell lymphoma显示文摘 | Bhatt VR Mourya R Shrestha R | 2015 | Cancer Treat Rev2015，68，3： | 1 |
| 7 | Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2显示文摘 | Mohanty S K Ivantes C A Mourya R | 2010 | Pediatr Res2010，67，4： | 1 |
| 8 | Isola- tion of chikungunya virus from aedes aegypti mosquitoes collected in the town of Yawat, Pune District, Maharashtra State, India 显示文摘 | MOURYA D T THAKARE J R GOKHALE M D | 2001 | Acta Yirol2001，45，： | 1 |
| 9 | Primary mediastinal large B-cell lymphoma显示文摘 | Bhatt VR Mourya R Shrestha R | 2015 | Cancer Treat Rev2015，41，6： | 1 |
| 10 | Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell line显示文摘 | Pratt J Mourya R | 2007 | Cell Signal2007，19，6： | 1 |
| 11 | Inhibition of mild steel corrosion in hydrochloric and sulfuric acid media using a thiosemicarbazone derivative 显示文摘 | Mourya P Banerjee S Rastogi R B | 2013 | Ind Eng Chem Res2013，52，12： | 1 |
| 12 | West Nile virus: the In- dian scenario显示文摘 | Paramasivan R Mishra AC Mourya DT | 2003 | Indian J Med Res2003，1，18： | 1 |
| 13 | Perforin and granzymes' work in synergy to mediate cholangiocyte injury in experimental biliary atresia 显示文摘 | Shivakunmr P Mourya R Bezerra JA | 2014 | J Hepatol2014，60，： | 1 |
| 14 | Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype显示文摘 | Li J Bessho K Shivakumar P Mourya R Mohanty S K Dos Santos J L | 2011 | J Clin Invest2011，121，： | 1 |
| 15 | Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2显示文摘 | Mohanty SK Ivantes CAP Mourya R | | 0，，04： | 1 |
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