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| 1 | Influences of multiphoton absorption and freecarrier effects on frequency-comb generation in normal dispersion silicon microresonators显示文摘We investigate frequency-comb generation in normal dispersion silicon microresonators from the near-infrared to mid-infrared wavelength range in the presence of multiphoton absorption and free-carrier effects. It is found that parametric oscillation is inhibited in the telecom wavelength range resulting from strong two-photon absorption.On the contrary, beyond the wavelength of 2200 nm, where three-and four-photon absorption are less detrimental,a comb can be generated with moderate pump power, or free-carriers are swept out by a positive-intrinsic-negative structure. In the temporal domain, the generated combs correspond to flat-top pulses, and the pulse duration can be easily controlled by varying the laser detuning. The reported comb generation process shows a high conversion efficiency compared with anomalous dispersion regime, which can guide and promote comb formation in materials with normal dispersion. As the comb spectra cover the mid-infrared wavelength range, they can find applications in comb-based radiofrequency photonic filters and mid-infrared spectroscopy. | MULONG LIU LEIRAN WANG QIBING SUN SIQI LI ZHIQIANG GE ZHIZHOU LU WEIQIANG WANG GUOXI WANG WENFU ZHANG XIAOHONG HU WEI ZHAO | 2018 | Photonics Research2018，6，4： | 4 |
| 2 | Flat soliton microcomb source显示文摘Mode-locked microcombs with flat spectral profiles provide the high signal-to-noise ratio and are in high demand for wavelength division multiplexing(WDM)-based applications,particularly in future high-capacity communication and parallel optical computing.Here,we present two solutions to generate local relatively flat spectral profiles.One microcavity with ultra-flat integrated dispersion is pumped to generate one relatively flat single soliton source spanning over 150 nm.Besides,one extraordinary soliton crystal with single vacancy demonstrates the local relatively flat microcomb lines when the inner soliton spacings are slightly irregular.Our work paves a new way for soliton-based applications owing to the relatively flat spectral characteristics. | Xinyu Wang Xuke Qiu Mulong Liu Feng Liu Mengmeng Li Linpei Xue Bohan Chen Mingran Zhang Peng Xie | 2023 | Opto-Electronic Science2023，2，12： | 1 |
| 3 | Genetic variants in the Hedgehog signaling pathway genes are associated with gastric cancer risk in a Chinese Han population显示文摘The Hedgehog signaling pathway participates in the occurrence and progression of cancers including gastric cancer.We conducted this study to evaluate whether genetic variants in the Hedgehog signaling pathway genes would affect gastric cancer risk.Multi-marker Analysis of GenoMic Annotation(MAGMA)was used to investigate the aggregated genetic effects of single nucleotide polymorphisms(SNPs)assigned to candidate genes.The relationship between SNPs and gastric cancer risk was estimated by multivariate logistic regression analyses.Gene expression was calculated using databases obtained from The Cancer Genome Atlas(TCGA)and The Gene Expression Omnibus(GEO).Kaplan‐Meier plotter was used to evaluate the association between gene expression with gastric cancer survival.Tumor Immune Estimation Resource 2.0(TIMER 2.0)was applied to determine the correlation between selected gene expression and the immune cell infiltration degree.We identified that the G allele of rs2990912 in KIF27 was associated with higher gastric cancer risk,especially in the young and male subgroups.The expression of KIF27 in gastric cancer tissues was higher than that in normal tissues,leading to poor survival in gastric cancer patients.Besides,KIF27 expression was related to immune cell infiltration and positively correlated with PD-L1 expression.Our findings highlight the key role of genetic variation in the Hedgehog signaling pathway genes in gastric cancer susceptibility,which may provide important insights into the diagnosis,prognosis,and treatment of gastric cancer. | Yujuan Zhang Kai Lu Xu Wu Hanting Liu Junyi Xin Xiaowei Wang Weida Gong Qinghong Zhao Meilin Wang Haiyan Chu Mulong Du Guoquan Tao Zhengdong Zhang | 2022 | The Journal of Biomedical Research2022，36，1： | 1 |
| 4 | Alternative polyadenylation-related genetic variants contribute to bladder cancer risk显示文摘Aberrant alternative polyadenylation(APA)events play an important role in cancers,but little is known about whether APA-related genetic variants contribute to the susceptibility to bladder cancer.Previous genome-wide association study performed APA quantitative trait loci(apaQTL)analyses in bladder cancer,and identified 17955 single nucleotide polymorphisms(SNPs).We found that gene symbols of APA affected by apaQTL-associated SNPs were closely correlated with cancer signaling pathways,high mutational burden,and immune infiltration.Association analysis showed that apaQTL-associated SNPs rs34402449 C>A,rs2683524 C>T,and rs11540872 C>G were significantly associated with susceptibility to bladder cancer(rs34402449:OR=1.355,95%confidence interval[CI]:1.159-1.583,P=1.33×10^(−4);rs2683524:OR=1.378,95%CI:1.164-1.632,P=2.03×10^(−4);rs11540872:OR=1.472,95%CI:1.193-1.815,P=3.06×10^(−4)).Cumulative effect analysis showed that the number of risk genotypes and smoking status were significantly associated with an increased risk of bladder cancer(P_(trend)=2.87×10^(−12)).We found that PRR13,being demonstrated the most significant effect on cell proliferation in bladder cancer cell lines,was more highly expressed in bladder cancer tissues than in adjacent normal tissues.Moreover,the rs2683524 T allele was correlated with shorter 3′untranslated regions of PRR13 and increased PRR13 expression levels.Collectively,our findings have provided informative apaQTL resources and insights into the regulatory mechanisms linking apaQTL-associated variants to bladder cancer risk. | Ting Liu Jingjing Gu Chuning Li Mengfan Guo Lin Yuan Qiang Lv Chao Qin Mulong Du Haiyan Chu Hanting Liu Zhengdong Zhang | 2023 | The Journal of Biomedical Research2023，37，6： | 0 |
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