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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | P450 BM3:the very model of a modern flavocytochrome 显示文摘 | MUNRO A W LEYS D G MCLEAN K J | 2002 | Trends Biochem Sci2002，27，5： | 1 |
| 3 | Determingtion of Sulfon-amide Residues in the Tissues of Food Animals Using Automated Precolumn Derivatization and Liquid Chromatography with Fluorescence Detection显示文摘 | Salisburk C D C Sweet J C Munro R | 2004 | J AOAC Int2004，87，5： | 1 |
| 4 | SLC2A9 is a high-capacity urate transporter in humans 显示文摘 | Caulfield M J Munroe P B O'Neill D | 2008 | PLoS Med2008，5，10： | 1 |
| 5 | SLC2A9 is a high-capacity urate transporter in humans显示文摘 | Caulfield M J Munroe PB O' Neill D | 2008 | PLoS Med2008，5，： | 1 |
| 6 | Gender and age affect balance performance in primary school-aged children显示文摘 | Mickle KJ Munro B J Steele JR | | 0，，： | 1 |
| 7 | Once more on the comparison of growth in fishes and invertebrates显示文摘 | Pauly D Munro J L | | 0，，： | 1 |
| 8 | The impact of NHS Di rect on the demand for out-of-hours primary and emer- gency care显示文摘 | Munro J Sampson F Nicholl J | 2005 | Br J Gen Pract2005，55，519： | 1 |
| 9 | Effects of mastiffs on milk yield, milk composition, processing properties and yield and quality of milk products Aust 显示文摘 | MUNRO E L GRIEVE P A KITCHEN B J | 1984 | Dairy Technol1984，39，： | 1 |
| 10 | 显示文摘 | PALMER J BURGI D S MUNRO N J | 2001 | Anal Chem2001，73，： | 1 |
| 11 | Marine natural prod- uets显示文摘 | Blunt J W Copp B R Munro M G H | 2004 | Nat Prod Rep2004，21，1： | 1 |
| 12 | Enhancement of marine fisheries resources显示文摘 | Munro J L Bell J D | | 0，，05： | 1 |
| 13 | Laboratory study of the influence of prey size on vulnerability to cannibalism in snow crab Chinonoecetes opilio ( Fabricius 1780) 显示文摘 | Dutil J D Munro J Peloquin M | 1997 | Journal of Experimental Marine Biology and Ecology1997，14，： | 1 |
| 14 | Threshold criteria for incipient sediment motion on an inclined bedform in the presence of oscillating-grid turbulence显示文摘 | WAN MOHTAR W H M MUNRO R J | 2013 | Physics of Fluids2013，25，01： | 1 |
| 15 | Cancer research in the global vil-lage显示文摘 | MUNRO A J NIBLOCK P G | 2010 | Lancet2010，376，9742： | 1 |
| 16 | Association of lymphadenectomy and survival in stage I ovarian cancer patients 显示文摘 | CHAN J K MUNRO E G CHEUNG M K | 2007 | Obstet Gynecol2007，109，1： | 1 |
| 17 | Observations on the use of rigid fixation for craniofacial deformities in infants and young children显示文摘 | Fearon J A Munro I R Bruce D A | 1995 | Plast Reconstr Surg1995，5，4： | 1 |
| 18 | Analysis of the Fecal Microflora of Human Subjects Consuming a Probiotic Product Containing Lac- tobacillus rhamnosus DR20显示文摘 | TANNOCK G W MUNRO K HARMSEN H J M | 2000 | Appl Environ Micro-biol2000，66，： | 1 |
| 19 | Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissellaspecies in human feces by using group-specific PCR primers anddenaturing gradient gel electrophoresis 显示文摘 | Walter J Hertel C Tannock GW Lis CM Munro K Hammes WP | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 20 | Exploring the limits of the National Ignition Facility’s capsule coupJing显示文摘 | Suter L Rothenberg J Munro D | 2000 | Physics of Plasmas2000，7，5： | 1 |
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