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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Realistic prospects for stem cell therapeutics显示文摘 | Daley GO Goodell MA Snyder EY | 2003 | Hematology Am Soc Hematol Educ Program2003，，： | 1 |
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| 5 | CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus 显示文摘 | Das KM Lee EY Enani MA | 2015 | AJR Am J Roentgenol2015，204，4： | 1 |
| 6 | Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell显示文摘 | Shin EY Ma EK Kim CK | 2002 | J Cancer Res Clin Oncol2002，128，11： | 1 |
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| 10 | Family A- nalysis of Linkage and Association of HLA-DRBI, CTLA4, TG- FB1 ,IL4, CCR5, RANTES, MMP9 and TIMP1 Gene Polymor- phisms with Multiple Sclerosis显示文摘 | Makarycheva OY Tsareva EY Sudomoina MA | 2011 | Acta Naturae2011，3，1： | 1 |
| 11 | Interaction between ( - SEA) alpha - thalassemia deletion and uncommon non - deletional alpha- globin gene mutations in Chinese patients 显示文摘 | Ma ES Chow EY Chan AY Chan LC | 2001 | Haematologi- ca2001，86，5： | 1 |
| 12 | Realistic prospects for stem cell therapeutics显示文摘 | Daley GQ Goodell MA Snyder EY | 2003 | Hematology Am Soc Hematol Educ Program2003，，： | 1 |
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| 15 | Evaluation of fumonisin-aflatoxin co-occurrence in Brazilian corn hybrids by ELISA 显示文摘 | Ono EY Ono MA Funo FY | 2001 | Food Addit Contain2001，18，8： | 1 |
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| 17 | Del -1,an endogenous leukocyte-endothelial adhesion inhibitor, limits in flammatorycell recruitment显示文摘 | Choi EY Chavakis E Czabanka MA | 2008 | Science2008，322，： | 1 |
| 18 | F - 18 FDG versus Ga -67 for detecting splenic involvement in Hodgkins disease显示文摘 | Rini JN Manalili EY Hoffman MA etal | 2002 | Clin Nucl Med2002，27，3： | 1 |
| 19 | Realistic prospects for stem cell therapeutics显示文摘 | Goodell MA Snyder EY | 2003 | Hematology (Am Soc Hematol Educ Program)2003，，： | 1 |
| 20 | CT correlation with out- comes in 15 patients with acute Middle East respiratory syndrome comnavirus 显示文摘 | Das KM Lee EY Enani MA | 2015 | AJR2015，204，4： | 1 |
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