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| 1 | Purification and characterization of cholecystokinin from the skin of salamander Tylototriton verrucosus显示文摘As a group of intestinal hormones and neurotransmitters, cholecystokinins(CCKs) regulate and affect pancreatic enzyme secretion, gastrointestinal motility, pain hypersensitivity, digestion and satiety, and generally contain a DYMGWMDFG sequence at the C-terminus. Many CCKs have been reported in mammals. However, only a few have been reported in amphibians, such as Hyla nigrovittata, Xenopus laevis, and Rana catesbeiana, with none reported in urodele amphibians like newts and salamanders. Here, a CCK called CCK-TV was identified and characterized from the skin of the salamander Tylototriton verrucosus. This CCK contained an amino acid sequence of DYMGWMDF-NH2 as seen in other CCKs. A c DNA encoding the CCK precursor containing 129 amino acid residues was cloned from the c DNA library of T. verrucosus skin. The CCK-TV had the potential to induce the contraction of smooth muscle strips isolated from porcine gallbladder, eliciting contraction at a concentration of 5.0x10-11 mol/L and inducing maximal contraction at a concentration of 2.0x10-6 mol/L. The EC50 was 13.6 nmol/L. To the best of our knowledge, this is the first report to identify the presence of a CCK in an urodele amphibian. | Wen-Bin JIANG Ma HAKIM Lei LUO Bo-Wen LI Shi-Long YANG Yu-Zhu SONG Ren LAI Qiu-Min LU | 2015 | Zoological Research2015，36，3： | 2 |
| 2 | Prevalence and risk factors of obesity and overweight in adult Saudi population显示文摘 | Alsaif MA Hakim IA Harris RB | 2002 | Nutrition Research2002，，22： | 1 |
| 3 | 显示文摘 | Huimin Ma Luis F Hakim Christopher N Bowman Robert Davis | 2001 | Membr Sci2001，189，： | 1 |
| 4 | Factors affecting membrane fouling reduction by surface modification and backpulsing显示文摘 | Ma H Hakim L F Bowman C N | 2001 | J Membr Sci2001，189，： | 1 |
| 5 | Factors affecting membrane fouling reduction by surface modification and backpulsing显示文摘 | Ma H Hakim F L Bowman C N | 2001 | Journal of Membrane Science2001，189，2： | 1 |
| 6 | A collagen-based scaffold for a tissue engineered human cornea:physical and physiological properties显示文摘 | Doilon CJ Watsky MA Hakim M Wang J Munger R Osborne R | 2003 | Int J Artif Organs2003，26，8： | 1 |
| 7 | Artificial human corneas:scaffolds for transplantation and host regeneration显示文摘 | Griffith M Hakim M Shimmura S Watsky MA Li F Carlesson D | 2002 | Cornea2002，21，7： | 1 |
| 8 | Tryptophan hydroxy- lase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression显示文摘 | Chen GL Novak MA Hakim S | 2006 | Mol Psychiatry2006，11，10： | 1 |
| 9 | A collagen based scaf- fold for a tissue engineered human cornea:Physieal and physio- logical properties显示文摘 | Doillon CJ Watsky MA Hakim M | 2003 | Int J Artif Organs2003，26，8： | 1 |
| 10 | Effect of topical fluoro- quinolones on the expression of matrix metalloproteinases in the cornea显示文摘 | Reviglio VE Hakim MA Song JK | 2003 | BMC Ophthalmol2003，3，10： | 1 |
| 11 | A collagen-based scaffold for a tissue engineered human cornea:physical and physiological properties显示文摘 | Doillon CJ Watsky MA Hakim M | 2003 | Int J Artif Organs2003，26，8： | 1 |
| 12 | Artificial human corneas:scaffolds for transplantation and host regeneration显示文摘 | Griffith M Hakim M Shimmura S Watsky MA Li F Carlsson D | 2002 | Cornea2002，21，7： | 1 |
| 13 | Outcome and predictive factors of acute renal failure in the intensive care unit显示文摘 | Bemieh B Hakim MA Boobes Y | 2004 | Transplant Proc2004，36，6： | 1 |
| 14 | Association between DHEAS and bone loss in postmenopausal women:a 15 -year longitudinal population-based study 显示文摘 | Ghebre MA Hart DJ Hakim AJ | 2011 | Calcif Tissue Int2011，89，4： | 1 |
| 15 | Factors affecting membrane fouling reduction by surface modification and backpulsing 显示文摘 | Ma H Hakim L F Bowman C N | 2001 | J Membr Sci2001，189，： | 1 |
| 16 | Factors affecting membrane fouling reduction by surface modification and backpulsing显示文摘 | Ma H Hakim L F Bowman C N etal | 2001 | J Membr Sci2001，189，： | 1 |
| 17 | Factors affecting membrane fouling reduction by surface modification and backpulsing显示文摘 | Hakim L F Bowman C N | 2001 | J Membr Sci2001，189，： | 1 |
| 18 | Intracellular pool of vascular endothelial growth factor in human neutrophils显示文摘 | Gaudry M Bregerie O Andrieu V Benna J Pocidalo MA Hakim J | 1997 | Blood1997，41，： | 1 |
| 19 | Intracellular pool of vascular endothelial growth factor in human neutrophils显示文摘 | Gaudry M Bregerie O Andrieu V El-Benna J Pocidalo MA Hakim J | 1997 | Blood1997，90，10： | 1 |
| 20 | Functional outcome of tension band wiring in closed patella fractures显示文摘 | DURRANI MA KHAN MA HAKIM A | 2010 | Pak J Surg2010，26，2： | 1 |
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