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| 1 | IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome显示文摘Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development. | Xiang Lin Xiaohui Wang Fan Xiao Kongyang Ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 13 |
| 2 | Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity显示文摘B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens andsignals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells.Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switchDNA recombination during B-cell activation and differentiation. Any abnormalities in these complex regulatoryprocesses may contribute to aberrant antibody production, resulting in autoimmune pathogenesis such as systemiclupus erythematosus. Newly generated knowledge from advanced modern technologies such as next-generationsequencing, single-cell sequencing and DNA methylation sequencing has enabled us to better understand B-cellbiology and its role in autoimmune development. Thus this review aims to summarize current research progress inepigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmuneconditions such as lupus, rheumatoid arthritis and type 1 diabetes. | Haijing Wu Yaxiong Deng Yu Feng Di Long Kongyang Ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu | 2018 | Cellular & Molecular Immunology2018，15，7： | 10 |
| 3 | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis显示文摘最近的研究在嗅觉的薄板 propria 作为居民干细胞的一种新类型识别了嗅觉的 ecto 间充质的干细胞(OE-MSCs ) 。然而,它仍然保持不清楚是否 OE-MSCs 拥有任何 immunoregulatory 功能。在这研究,我们发现老鼠 OE-MSCs 比骨头表示了更高转变的生长因素贝它和 interleukin-10 层次导出髓的 MSC。在文化, OE-MSCs 经由直接压制受动器 T 房间增长并且增加规章的 T (Treg ) 房间扩大施加了他们的抑制免疫力的能力。在有导致骨胶原的关节炎的老鼠, OE-MSCs 的采纳转移显著地压制了关节炎发作和疾病严厉,它被增加的 Treg 房间伴随并且在 vivo 减少了 Th1/Th17 房间回答。一起拿,我们的调查结果在调整 T 房间回答识别了 OE-MSCs 的新奇功能,显示那 OE-MSCs 可以为风湿性关节炎和另外的自体免疫的疾病的处理代表新房间治疗。 | Ke Rui Zhijiang Zhang Jie Tian Xiang Lin Xiaohui Wang Jie Ma Xinyi Tang Huaxi Xu Liwei Lu Shengjun Wang | 2016 | Cellular & Molecular Immunology2016，13，3： | 8 |
| 4 | A review of fundamental factors affecting diesel PM oxidation behaviors显示文摘Diesel particulate matter(DPF) is usually employed to meet the stringent regulations on particulate matter(PM) emissions for diesel engine. To resolve the DPF regeneration problem, comprehensive information about the factors influencing PM oxidation behaviors must be understood. Large amounts of factors related to PM oxidation activity have been investigated, however, some relations are still ambiguous. This paper reviews the factors related to PM oxidation activity that the factors are divided into the engine-correlated and engine-uncorrelated factors. The methods with both advantages and disadvantages to test the oxidation behaviors are introduced. The microstructure and ingredient being fundamental factors affecting PM oxidation behaviors are as the principle line to correlate PM oxidation behaviors and engine-correlated factors. The relations of engine-correlated factors with oxidation behaviors are obtained though advanced technologies that are mutual complementation. The engine-uncorrelated factors are also reviewed that these factors are vital to oxidation activity changes. Multiple-factor analysis rather than single-factor analysis should be developed to make the oxidation behaviors of diesel PM more clear. | GAO JianBing MA ChaoChen XING ShiKai SUN LiWei HUANG LiYong | 2018 | Science China(Technological Sciences)2018，61，3： | 8 |
| 5 | Crack behavior in Mg/Al alloy thin sheet during hot compound extrusion显示文摘A novel and effective method to co-extrude metallic alloys is described which named Direct Extrusion and Bending-Shear Deformation.The compound extrusion plates have cracked at 290℃ and 3 mm/s.According to this phenomenon,a model was built to investigate the crack generation and development between the 6061 Al and AZ31 Mg alloy during the compound extrusion process by DEFORM-3D.The cracking behavior of the Mg/Al composite rod with a soft Mg AZ31 core and a hard Al 6061 sleeve were systematically studied to disclose the influence of microstructure on crack in the different regions.The simulation results show that the distribution of strain and velocity has significant differences due to the influence of dies structure and material properties at different locations in the same region.The experimental results show that in the same conditions,there are differences in recrystallization and texture weakening of AZ31 Mg alloys and 6061 Al alloy,which are important factors for the formation of crack.Both the Mg layer and the Al layer have a homogeneous microstructure in the region d. | Kun Sheng Liwei Lu Yao Xiang Min Ma Zhiqiang Wu | 2019 | Journal of Magnesium and Alloys2019，7，4： | 8 |
| 6 | Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness显示文摘人的表皮的干细胞(EpSCs ) 的丰富和鉴定具有为基本研究和临床的申请的首要的重要性。尽管为 EpSCs 的丰富的几条途径被建立了,充实可行 EpSCs 的一张纯人口仍然是一项挑战性的任务。一条改进途径值得发展提高 EpSCs 的纯净和生存能力。这里,我们报导那种房间尺寸与骨胶原类型 IV 粘着性结合了能在一条改进途径被使用充实纯、可行的人的 EpSCs。我们分开了很快支持者 keratinocytes 进从 5-7 microm (人口 A )在尺寸 的三张人口到 7-9 microm (人口 B ),到>或在直径的 =9 microm (人口 C ),并且发现人的通常认为的 EpSCs 能进一步与最小的尺寸在人口 A 被充实。在三张人口之中,人口 A 显示了 beta1-integrin 受体的最高的密度,在 G0/G1 阶段包含了房间的最高的百分比,显示出最高的原子核到细胞质比率,并且拥有了最高的殖民地形成效率(CFE ) 。当注入了鼠科的胚囊时,这些房间参予了多织物形成。与根据 beta1-integrin 抗体染色排序通常认为的 EpSCs 的一条以前的途径相比,更显著地, EpSCs 的生存能力由改进途径充实显著地被提高。我们的结果为人的 EpSCs 的丰富提供通常认为的策略,并且在干细胞生物学鼓励进一步的学习进房间尺寸的角色。 | Juxue Li Chenglin Miao Welxiang Guo Liwei Jia Jiaxi Zhou Baohua Ma Sha Peng Shuang Liu Yujing Cao Enkui Duan | 2008 | Cell Research2008，18，3： | 8 |
| 7 | Point-of-Interest Recommendation in LocationBased Social Networks with Personalized Geo-Social Influence显示文摘Point-of-interest(POI) recommendation is a popular topic on location-based social networks(LBSNs).Geographical proximity,known as a unique feature of LBSNs,significantly affects user check-in behavior.However,most of prior studies characterize the geographical influence based on a universal or personalized distribution of geographic distance,leading to unsatisfactory recommendation results.In this paper,the personalized geographical influence in a two-dimensional geographical space is modeled using the data field method,and we propose a semi-supervised probabilistic model based on a factor graph model to integrate different factors such as the geographical influence.Moreover,a distributed learning algorithm is used to scale up our method to large-scale data sets.Experimental results based on the data sets from Foursquare and Gowalla show that our method outperforms other competing POI recommendation techniques. | HUANG Liwei MA Yutao LIU Yanbo | 2015 | China Communications2015，12，12： | 6 |
| 8 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 9 | Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome显示文摘Immunoproteasome activation in immune cells is involved in the modulation of immune responses.Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases,but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren’s syndrome(SS).Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS(ESS)in mice.In this study,we detected high levels of low-molecular-weight protein 7(LMP7),a key subunit of the immunoproteasome,in Th17 cells from ESS mice.Moreover,treatment with bortezomib(BTZ),a proteasome inhibitor,markedly suppressed Th17 differentiation in both murine and human naive T cells in culture.Furthermore,ESS mice treated with BTZ displayed significantly higher saliva flow rates and a reduction in tissue destruction in the salivary glands compared with vehicle-treated ESS mice.Notably,BTZ-treated ESS mice showed markedly decreased Th17 cells,germinal center B cells and plasma cells in the peripheral lymphoid organs.In addition,adoptively transferred wild type naive CD4+T cells rapidly differentiated into Th17 cells and induced salivary dysfunction in IL-17-deficient mice immunized for ESS induction.However,BTZ treatment profoundly suppressed the donor T-cell-derived Th17 response and ameliorated the reduction in salivary secretion in IL-17-deficient recipient mice.Taken together,our findings demonstrate that proteasome inhibition can effectively ameliorate ESS by suppressing the Th17 response,which may contribute to the development of a novel therapeutic strategy for the treatment of SS. | Fan Xiao Xiang Lin Jie Tian Xiaohui Wang Qian Chen Ke Rui Jie Ma Shengjun Wang Qingwen Wang Xiaoqi Wang Dongzhou Liu Lingyun Sun Liwei Lu | 2017 | Cellular & Molecular Immunology2017，14，11： | 6 |
| 10 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 11 | Full automorphism group of the generalized symplectic graph显示文摘Let Fq be a finite field of odd characteristic, m, ν the integers with 1≤m≤ν and Ka 2ν× 2ν nonsingular alternate matrix over Fq. In this paper, the generalized symplectic graph GSp2ν (q, m) relative to K over Fq is introduced. It is the graph with m-dimensional totally isotropic subspaces of the 2ν-dimensional symplectic space F(2ν)q as its vertices and two vertices P and Q are adjacent if and only if the rank of PKQT is 1 and the dimension of P ∩ Q is m-1. It is proved that the full automorphism group of the graph GSp2ν(q, m) is the projective semilinear symplectic group PΣp(2ν, q). | ZENG LiWei CHAI Zhao FENG RongQuan MA ChangLi | 2013 | Science China Mathematics2013，56，7： | 4 |
| 12 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 13 | Impact of Land Use Change on Vegetation Carbon Storage During Rapid Urbanization:A Case Study of Hangzhou,China显示文摘Land use changes have significant impacts on the carbon balance in an urban ecosystem.When there is rapid development in urbanizing regions,land use changes have a dramatic effect on vegetation carbon storage(VCS).This study investigates the impact of land use change on VCS in a period of rapid urbanization in Hangzhou,China.The results show that:1)from 2000 to 2015,land use in Hangzhou underwent huge changes,mainly reflected in decrease in cropland and wetland and the increased settlement.More than 34.58%of the land was transformed,and the land use changes are primarily characterized by a significant decrease in cropland due to the occupation by settlement.2)over the 15 years,changes in land use led to a decrease of 3.93×10^(5) t of VCS in the urban ecosystem.The large-scale transformation of cropland and wetland,which have a comparatively high carbon density,into land for settlement exerted a negative impact on VCS.3)The central city,which with the Circle-E/I/O mode,had the lowest comprehensive land use dynamic degree,leading to moderate land use change and an increase in VCS;Yuhang and Xiaoshan,which with Multicore-E/O/I mode and Fan-E/O/I modes,had a higher comprehensive land use dynamic degree,drastic changes in land use,and a decrease in VCS.This study proposes a reliable method of estimating changes in VCS,clarifies the relationship between land use change and VCS during rapid urbanization,and provides recommendations for sustainable urban development. | WANG Zhi XU Lihua SHI Yijun MA Qiwei WU Yaqi LU Zhangwei MAO Liwei PANG Enqi ZHANG Qi | 2021 | Chinese Geographical Science2021，31，2： | 3 |
| 14 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 15 | REMOTE SENSING OF ALGAL BLOOMS USING A TURBIDITY-FREE FUNCTION FOR NEAR-INFRARED ANDRED SIGNALS显示文摘This article presents a method for real- time mapping of algal blooms in turbid coastal waters using the remote sensing reflectance of red band (Channel 1, 580-680 nm) and near-infrared band (Channel 2, 720-1100 nm) of the AVHRR sensor on the NOAA series satellites. A turbidity-free function for near-infrared and red signals, α0 = (bb(1)/bb(2))(a(2)/ a(1)) based on the first order bb/(a+bb) model deduc-ing equation Rrs(2)?1 = α0 Rrs(1) ?1+ g?1 (1?α0), were se-lected as a chlorophyll-a related index for detecting algal blooms, and the algal blooms with chlorophyll-a concentration of 64-256 mg/L could be defined by window of 1.6 < α0 < 5.2 and 0.01< Rrs(2)/g < 0.2. Such turbidity-free two-band method is supported by both sea-truth data and remote sensing experiment for an algal blooms event on the near-shore water off the Minjiang estuary of southeastern China during early June of 2003. Comparisons of this algorithm with other published algorithms, one-band method (i.e. method of bright water) or two-band methods (i.e. method of ratio, method of NDVI, and method of subtracting) have suggested that the turbidity-free function method could be regarded as a standard algorithm in capabilities of AVHRR imagery or other high resolution but wide near-infrared and red band imagery for detecting algal blooms events in coastal waters. | LI Yan SHANG Shaoling ZHANG Caiyun MA Xiaoxin HUANG Liwei WU Jingyu ZENG Yindong | 2006 | Chinese Science Bulletin2006，51，4： | 2 |
| 16 | Short body length phenotype is compensated by the upregulation of nidogen family members in a deleterious nid1a mutation of zebrafish显示文摘To decode biological processes,interfering with gene functions is a widely used strategy.There are a number of ways to interfere with gene functions.For instance,small interfering RNAs(siRNAs)are used to induce mRNA degradation;morpholinos are used to block protein translation(Nasevicius and Ekker,2000);CRISPR interference/inactive CRISPR-associated 9 nuclease(CRISPR-i/dCas9)is used to block mRNA transcription(Qi et al.,2013); | Peipei Zhu Zhipeng Ma Liwei Guo Wei Zhang Qinghe Zhang Ting Zhao Kunpeng Jiang Jinrong Peng Jun Chen | 2017 | Journal of Genetics and Genomics2017，44，11： | 2 |
| 17 | Progress of Optical Fiber Sensors and Its Application in Harsh Environment显示文摘Fiber sensors have been developed for industry application with significant advantages.In this paper,Fiber sensors for oil field service and harsh environment monitoring which have been investigated in Tsinghua University are demonstrated.By discussing the requirements of practical applications,the key technologies of long-period fiber grating(LPFG)based fiber sensor,optical spectrum analyzer for oil detection,laser induced breakdown spectroscopy(LIBS)system for soil contamination monitoring,and seismic sensor arrays are described. | Min ZHANG Xiaohong MA Liwei WANG Shurong LAI Hongpu ZHOU Huafeng ZHAO Yanbiao LIAO | 2011 | Photonic Sensors2011，1，1： | 2 |
| 18 | The expanding functional diversity of plasma cells in immunity and inflammation显示文摘The generation and function of plasma cells have been well recognized as the central events in humoral immunity.In particular,long-lived plasma cells,characterized by a long lifespan and the lack of cell division,persistently secrete high-affinity antibodies to maintain serum antibody titers in the immune response and autoimmune inflammation.Although the significant expansion of plasma cells is observed during the aging process,autoimmune diseases and chronic infections,the expanding functional diversity and underlying mechanisms of plasma cells remain incompletely understood.Here,we describe recent advances in revealing new functional subsets and phenotypic features of plasma cells in aging and autoimmunity. | Kongyang Ma Xiaohui Wang Xiaofei Shi Xiang Lin Fan Xiao Xin Ma Dongzhou Liu Liwei Lu | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 19 | New insights into the significance of the BCR repertoire in B-1 cell development and function显示文摘As an important player of innate immunity,B-1 cells have been characterized by natural antibody production and rapid immune response.Based on their expression or lack of CD5,B-1 cells are further separated into B-1a and B-1b subsets.1 Although extensive studies have demonstrated a pivotal role of conventional B cells in adaptive immunity,there is increasing evidence indicating the close associations of B-1a cells with self-reactivity,autoimmunity,infection,and even leukemia.2–4 Here,we describe recent advances that lead to a clearer understanding of B-1 cell development with a focus on new insights into the significance of the B-cell receptor(BCR)repertoire in B-1a cell biology and discuss the potential strategies for specific targeting of B-1a cells under pathological settings. | Xiaohui Wang Cong Ye Xiang Lin Kongyang Ma Fan Xiao Lingli Dong Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，9： | 2 |
| 20 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
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