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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | Evolutionary history and phylogeography of Scots pine (Pinus sylvestris L.) in Europe based on molecular markers显示文摘In this review we summarized recent historical records and molecular studies on evolutionary history and phylogeography of Scots pine with focus on the European highly fragmented distribution area of the species. Fossilized pollen, plant micro-and macrofossil records provided evidences on the large-scale species' range shifts and demographic changes during the Quaternary. Populations of Scots pine were documented both in the glacial(incl.full glaciation) and interglacial periods. Recolonization of Europe after the glaciation originated from the(Sub)Mediterranean areas like the Balkan Peninsula but also from around the Eastern Alps and the surroundings of the Danube plain. Fennoscandia and northern European Baltic regions were most probably colonized from two main directions, from Western Europe and from the Russian Plain. Modern history of Scots pine was hardly affected by anthropogenic activities that started to strengthen in the Bronze and Iron Age. Along with the fossil records,molecular genetic tools were used to infer the origin and putative history including migration, differentiation and demography of the species. In this paper we compiled the major publications(30) of molecular genetic studies of the past 20 years derived from distinctly inherited organelle genomes(mitochondrial, chloroplast, nuclear) revealed by different marker systems(mt DNA-cox1,-nad1,-nad3,-nad7, ISSR, cp SSR, n SSR, B-SAP, SNP). It is important to consider that different phylogeographic patterns can be drawn by the analysis of different DNA marker types.Accordingly the use of more than one marker simultaneously outlines the most sophisticated phylogeographical pattern on the genetic lineages and can reveal high differentiation of the European distribution. Combined marker systems and markers derived from coding sequences have also been used to detect species' phylogeographic patterns,but these were rarely applied to Scots pine. Although new molecular techniques can provide higher resolution data for populations, the reviewed results can shape the direction of further studies. | Endre Gy. To′th Zolta′n A. Kobolkuti Andrzej Pedryc Ma′ria Hohn | 2017 | Journal of Forestry Research2017，28，4： | 3 |
| 3 | Review of the genotoxicity of formaldehyde exposure显示文摘 | Ma TH Harris MM | 1990 | Pro Am Assoc Cancer Res1990，31，： | 2 |
| 4 | 世界性环境监测计划及展望显示文摘一、世界环境问题 很难得有这个机会与我们祖国同胞们在一起讨论一些环境问题。各位从新闻媒介中,一定也已经知道我们这个地球的健康状况令人担忧。现在,在巴西的里约热内卢,正在召开“联合国环境与发展大会”(1992.6.3—6.14),各国元首和政府首脑出席了会议,共同审议地球和人类所面临的环境与发展问题,寻求积极的对策。与此同时,即1992.6.1—6.5,在葡萄牙召开了“ | Ma,TH 蔡亚娜 | 1993 | 癌变.畸变.突变1993，5，4： | 2 |
| 5 | Organ injury scaling Ⅱ:pancreas , duodenum, small bowel, colon and rectum 显示文摘 | Moore EE Gogbil TH Malangoni MA | 1990 | Trauma1990，30，11： | 1 |
| 6 | Organ injury scaling, lit Pancreas, duodenum, small bowel colon, and rectum 显示文摘 | Moore EE Cogbill TH Malangoni MA | 1990 | J Trauma1990，30，： | 1 |
| 7 | Water channel activity of plasma membrane affects chondrocyte migration and adhesion显示文摘 | Liang HT Feng XC Ma TH | 2008 | Clin Exp Pharmacol Physiol2008，35，： | 1 |
| 8 | Pancreatic cancer pain anti its correlation with changes in tumor vasculature,macrophage infiltration,neuronal innervation,body weight and disease progression显示文摘 | Lindsay TH Jonas BM Sevcik MA | 2005 | Pain2005，119，13： | 1 |
| 9 | Advances in Gastrointesti nal Intervention:The Treatment of Gastroduodenal and Colorectal Obstructions with Metallic Stents显示文摘 | Mauro MA Koehler RE Baron TH | 2000 | Radiology2000，215，3： | 1 |
| 10 | Use of intraoperative ultrasonography to localize islet cell tumors显示文摘 | Zeiger MA Shawker TH Norton JA | 1993 | World J Surg1993，17，4： | 1 |
| 11 | Organ injury scalin II : pancreas, duodenum, small bowel, colon and rectum 显示文摘 | MOORE EE COGBILL TH MALANGONI MA | 1990 | J Trauma1990，30，11： | 1 |
| 12 | Comorbidity as a predictor and moderator of treatment outcome in youth with anxiety, affective,attention deficit/hyperactivity disorder,and oppositional/conduct disorders 显示文摘 | Ollendick TH Jarrett MA Grills - Taquechel AE | 2008 | Clin Psychol Rev2008，28，8： | 1 |
| 13 | Organ injury scaling Ⅱ:pancreas,duodenum,small bowel colon and rectum显示文摘 | Cogbill TH Malangoni MA | 1990 | J Trauma1990，30，： | 1 |
| 14 | Organinjury scaling,Ⅱ,Pancreas,duodenum,small bowel,colon,and rectum显示文摘 | Moore EE Cogbill TH Malangoni MA | 1990 | J Trauma1990，30，： | 1 |
| 15 | Organ injury scaling Ⅱ:pancreas,duodenum,small bowel,colon and rectum显示文摘 | Moore EE Cogbill TH Malangoni MA | 1990 | J Trauma1990，30，11： | 1 |
| 16 | An outcomes analysis of patients undergoing body contouring surgery after massive weight loss显示文摘 | Shermak MA Chang D Magnuson TH et a1 | 2006 | Plast Reconstr Surg2006，118，： | 1 |
| 17 | Cerebral blood velocity and other cardiovascular responses to 2 days of head-down tilt显示文摘 | Frey MA Mader TH Bagian JP | 1993 | J Appl Physiol1993，74，1： | 1 |
| 18 | T cell co-stimulatory molecules other than CD28显示文摘 | Watts TH DeBenedette MA | 1999 | Curr Opin Immunol1999，11，： | 1 |
| 19 | Organ injury scaling,Ⅱ:Pancreas,duodenum,small bowel,colon,and rectum显示文摘 | Moore EE Cogbill TH Malangoni MA | 1990 | J Trauma1990，30，11： | 1 |
| 20 | Functional display of Pseudomonas and Burkholderia lipases using a translocator domain of EstA autotransporter on the cell surface of Escherichia coli显示文摘 | Yang TH Kwon MA Song JK | 2010 | J Biotechno2010，146，3： | 1 |
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