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3篇 您的检索式：作者名="Ma Yangyun"

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		题名	作者	年代	出处	被引量
	1	High-quality MeV protons from laser interaction with umbrellalike cavity target显示文摘	Ma Yangyun Sheng Zhengming Gu Yuqiu	2009	Physics of Plasmas2009，16，03：	1
	2	Quasimonoenergetic proton beam from ultraintense-laser irradiation of a target with holed backside显示文摘	Yu Tongpu Ma Yangyun Chen Ming	2009	Physics of Plasmas2009，16，03：	1
	3	Visualizable Delivery of Nanodisc Antigen-Conjugated Adjuvant for Cancer Immunotherapy显示文摘Engineering synthetic vaccines is promising for improving the efficacy of cancer immunotherapy.One of the major challenges in the development of vaccines is achieving controllable codelivery of antigen and adjuvant to lymph nodes for maximizing the antitumor immune responses.To address this issue,we herein developed an innovative visualizable nanodisc vaccine based on ovalbumin(OVA)and short-stranded oligodeoxynucleotides containing unmethylated cytosine-phosphate-guanine(CpG)motifs.The nanovaccine was fabricated by covalently attaching CpG onto the surface of a nanodisc antigen formed upon self-assembly of amphiphilic molecular conjugates of OVA and cypate(Cy),a near-infrared(NIR)fluorescent dye,for noninvasively visualizing the delivery of the resulting nanovaccines.Systematic in vitro experiments demonstrated that the engineered nanovaccines can specifically locate to dendritic cells(DCs)via toll-like receptor 9 and membrane thiols,and then efficiently activate DCs.The animal experiments combining NIR fluorescence imaging with the lymphatic T-cell phenotype and key cytokine secretion analyses revealed that targeted lymphatic homing of the mature DCs and consequent priming of CD8^(+)T cells were enabled to initiate strong tumor-specific T-cell responses with robust immune memory effects.Thus,this study offers a visualizable platform for optimizing the efficacy of nanovaccines toward cancer immunotherapies.	Yangyun Wang Subin Lin Hanqiu Jiang Yuan Gu Yanxian Wu Jie Ma Yubin Ke Leshuai W.Zhang Yong Wang Mingyuan Gao	2022	CCS Chemistry2022，4，4：	0

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