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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | High rates of HBsAg seroconversion in HBeAg-positive chronic hepatitis B patients responding to interferon: A long-term follow-up study显示文摘 | Rami Moucari Anneke Korevaar Olivier Lada Michelle Martinot-Peignoux Nathalie Boyer Vincent Mackiewicz Agnes Dauvergne Ana C. Cardoso Tarik Asselah Marie-Hélène Nicolas-Chanoine Michel Vidaud Dominique Valla Pierre Bedossa Patrick Marcellin | 2009 | Journal of Hepatology2009，，6： | 2 |
| 3 | Phenotypic plasticity can explain evolution of sympatric polymorphism in the hairy snail Trochulus hispidus (Linnaeus, 1758)显示文摘 | Matgorzata PROCKOW Elzbieta KUZNIK-KOWALSKA Pawet MACKIEWICZ | 2017 | Current Zoology2017，63，4： | 2 |
| 4 | Localization of intraocular foreign bodies using computed tomography 显示文摘 | Mackiewicz J Krupski W Haszcz D | 2001 | Klin Oczna2001，103，1： | 1 |
| 5 | Growth and early bearing of apple trees as affected by the type of nursery trees used for planting 显示文摘 | Sadowski A Mackiewicz M Dziuban R | 2007 | Acta Horticulturae2007，732，： | 1 |
| 6 | Isolation and characterisation of KP34-a novel phiKMV-like bacteriophage for Nlebsiella pneumoniae 显示文摘 | Drulis-Kawa Z Mackiewicz P Kesik-Szeloch A | 2011 | App Microbiol Biotechnology2011，90，4： | 1 |
| 7 | Intedeukin-6 and oncostatin M-induced growth inhibition of uman A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1 显示文摘 | Kortylewski M Heinrich PC Mackiewicz A | 1999 | Oncogene1999，18，25： | 1 |
| 8 | Localization of intraocular foreign bodies using computed tomography显示文摘 | Mackiewicz J Krupski W Haszcz D | 2001 | Klin Oczna2001，103，1： | 1 |
| 9 | Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients显示文摘 | Moucari R Mackiewicz V Lada O | 2009 | Hepatology2009，49，22： | 1 |
| 10 | Design of clinical trials for therapeutic cancer vaccines development 显示文摘 | Mackiewicz J Mackiewicz A | 2009 | Eur J Pharmacol2009，625，13： | 1 |
| 11 | Molecular signatures of obstructive sleep apnea in adults: a re'view and perspective显示文摘 | Arnardottir ES Mackiewicz M Gislason T | 2009 | Sleep2009，32，4： | 1 |
| 12 | Early serum HBsAg drop:a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients显示文摘 | Moucari R Mackiewicz V Lada O | | 0，，4： | 1 |
| 13 | Early serum HBsAg drop:A strong predictor of sustained virological response to pe-gylated interferon alfa-2a in HBeAg-negative patients显示文摘 | Moucari R Mackiewicz V Lada O | | 0，，04： | 1 |
| 14 | Molecular signatures of obstructive sleep apnea in aduhs:a review and perspective显示文摘 | Amardottir ES Mackiewicz M Gislason T | 2009 | Sleep2009，32，4： | 1 |
| 15 | Copolymerization of CO2 and epoxides catalyzed by metalsalencomplexes显示文摘 | DARENSBOURG D J MACKIEWICZ R M PHELPS A L | 2004 | AccounlsChemRes2004，37，11： | 1 |
| 16 | Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR- 34a microRNA 显示文摘 | Mackiewicz M Huppi K Pitt JJ | 2011 | Breast Cancer Res Treat2011，130，2： | 1 |
| 17 | Asphalt mixes deformationsensitivity to change in rheological parameters显示文摘 | Szydlo A Mackiewicz P | 2005 | Journal of Materials in Civil Engineering2005，17，1： | 1 |
| 18 | Briefpostinfarction calcineurin blockade affects left ventricularremodeling and Ca2+handling in the rat显示文摘 | Mackiewicz U Maczewski M Klemenska E | 2010 | J Mol CellCardiol2010，48，6： | 1 |
| 19 | Principal components analysis (PCA) 显示文摘 | Mackiewicz A Ratajczak W | 1993 | Computers and Geosciences1993，19，： | 1 |
| 20 | Intestine and Colon Tissue Discriminators for Wireless Capsule Endoscopy hnages 显示文摘 | Mackiewicz Michal Bell | 2005 | Medical imaging2005，5747，1： | 1 |
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