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| 1 | A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia显示文摘AIM:To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease(NAFLD)and hyperferritinemia,a frequent feature associated with more severe liver damage,despite at least 6 mo of lifestyle changes.METHODS:Eligible subjects had to be 18-75 years old who underwent liver biopsy for ultrasonographically detected liver steatosis and hyperferritinemia,ferritin levels≥250 ng/mL,and NAFLD activity score>1.Iron depletion had to be achieved by removing 350 cc of blood every 10-15 d according to baseline hemoglobin values and venesection tolerance,until ferritin<30 ng/mL and/or transferrin saturation(TS)<25%.Thirty-eight patients were randomized 1:1 to phlebotomy(n=21)or lifestyle changes alone(n=17).The main outcome of the study was improvement in liver damage according to the NAFLD activity score at 2 years,secondary outcomes were improvements in liver enzymes[alanine aminotransferases(ALT),aspartate aminotransferase(AST),and gamma-glutamyl-transferases(GGT)].RESULTS:Phlebotomy was associated with normalization of iron parameters without adverse events.In the21 patients compliant to the study protocol,the rate of histological improvement was higher in iron depleted vs control subjects(8/12,67%vs 2/9,22%,P=0.039).There was a better improvement in steatosis grade in iron depleted vs control patients(P=0.02).In patients followed-up at two years(n=35),ALT,AST,and GGT levels were lower in iron-depleted than in control patients(P<0.05).The prevalence of subjects with improvement in histological damage or,in the absence of liver biopsy,ALT decrease≥20%(associated with histological improvement in biopsied patients)was higher in the phlebotomy than in the control arm(P=0.022).The effect of iron depletion on liver damage improvement as assessed by histology or ALT decrease≥20%was independent of baseline AST/ALT ratio and insulin resistance(P=0.0001).CONCLUSION:Iron depletion by phlebotomy is likely associated with a higher rate of improvement of histological liver damage than lifestyle changes alone in patients with NAFLD and hyperferritinemia,and with amelioration of liver enzymes. | Luca Valenti Anna Ludovica Fracanzani Paola Dongiovanni Serena Rovida Raffaela Rametta Erika Fatta Edoardo Alessandro Pulixi Marco Maggioni Silvia Fargion | 2014 | World Journal of Gastroenterology2014，20，11： | 8 |
| 2 | NOTES transvaginal cholecystectomy: preliminary clinical application显示文摘 | R. Zorron L. C. Maggioni L. Pombo A. L. Oliveira G. L. Carvalho M. Filgueiras | 2008 | Surgical Endoscopy2008，，2： | 5 |
| 3 | Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis显示文摘AIM: To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3 ) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH). METHODS: We studied 174 consecutive unrelated homozygous for the C282Y HFE mutation of HH (C282Y+/+ HH) patients from Northern Italy, for whom the presence of cirrhosis could be determined based on histological or clinical criteria, without excessive alcohol intake (< 30/20 g/d in males or females) or hepatitis B virus and hepatitis C virus viral hepatitis. Steatosis was evaluated in 123 patients by histology (n = 100) or ultrasound (n = 23). The PNPLA3 rs738409 single nucleotide polymorphism, encoding for the p.148M protein variant, was genotyped by a Taqman assay (assay on demand, Applied Biosystems). The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis. RESULTS: PNPLA3 genotype was not associated with metabolic parameters, including body mass index (BMI), the presence of diabetes, and lipid levels, but the presence of the p.148M variant at risk was independently associated with steatosis [odds ratio (OR) 1.84 per p.148M allele, 95% confidence interval (CI): 1.05-3.31; P = 0.037], independently of BMI and alanine amino-transaminase (ALT) levels. The p.148M variant was also associated with higher aspartate aminotransferase (P = 0.0014) and ALT levels (P = 0.017) at diagnosis, independently of BMI and the severity of iron overload. In patients with liver biopsy, the 148M variant was independently associated with the severity (stage) of fibrosis (estimated coefficient 0.56 ± 0.27, P = 0.041). In the overall series of patients, the p.148M variant was associated with cirrhosis in lean (P = 0.049), but not in overweight patients (P = not significant). At logistic regression analysis, cirrhosis was associated with BMI ≥ 25 (OR 1.82, 95% CI: 1.02-3.55), ferritin > 1000 ng/mL at diagnosis (OR 19.3, 95% CI: 5.3-125), and with the G allele in patients with BMI < 25 (OR 3.26, 95% CI: 1.3-10.3). CONCLUSION: The PNPLA3 I148M polymorphism may represent a permissive factor for fibrosis progression in patients with C282Y+/+ HH. | Luca Valenti Paolo Maggioni Alberto Piperno Raffaela Rametta Sara Pelucchi Raffaella Mariani Paola Dongiovanni Anna Ludovica Fracanzani Silvia Fargion | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 4 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma显示文摘 | R. Pugliese D. Maggioni F. Sansonna I. Scandroglio G. C. Ferrari S. Lernia A. Costanzi J. Pauna P. Martini | 2007 | Surgical Endoscopy2007，，1： | 3 |
| 5 | Electronic fiber-optic technology: future options for permanent reservoir monitoring显示文摘 | Giovanni Botto Bruno Maggioni Adelmo Schenato | 1994 | SPE paper 284841994，，： | 2 |
| 6 | Total and subtotal laparoscopic gastrectomy for adenocarcinoma显示文摘 | Pugliese R Maggioni D Sansonna F | | 0，，01： | 2 |
| 7 | Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction显示文摘 | Alejandro Macchia Simona Monte Fabio Pellegrini Marilena Romero Daniel Ferrante Hernán Doval Antonio D'Ettorre Aldo Pietro Maggioni Gianni Tognoni | 2008 | European Journal of Clinical Pharmacology2008，，6： | 2 |
| 8 | Statin use and non-alcoholic steatohepatitis in at risk individuals显示文摘 | Paola Dongiovanni Salvatore Petta Ville Mannisto Rosellina Margherita Mancina Rosaria Pipitone Vesa Karja Marco Maggioni Pirjo Kakela Olov Wiklund Enrico Mozzi Stefania Grimaudo Dorota Kaminska Raffaela Rametta Antonio Craxi Silvia Fargion Valerio Nobili | 2015 | Journal of Hepatology2015，，3： | 2 |
| 9 | Valsartan reduces the incidence of artrial fibrillation in patients with heart failure:results from the Valsartan Heart Failure Trail(Val -HeFT)显示文摘 | Latini R Carson PE | 2005 | Am Heart J2005，149，3： | 1 |
| 10 | Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma显示文摘 | Augello C Caruso L Maggioni M | 2009 | BMC Cancer2009，9，： | 1 |
| 11 | Catechol and hydroquinone from catalytic hydroxylation of phenol by hydrogen peroxide显示文摘 | MAGGIONI P MINISCI F | 1977 | Chim Ind( Milano)1977，59，： | 1 |
| 12 | Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure ( the GISSI-HF trial ) : a randomised, double-blind, placebo-con- trolled trial 显示文摘 | GISSI-HF Investigators Tavazzi L Maggioni AP | 2008 | Lancet2008，372，9645： | 1 |
| 13 | Clinical implications of QRS duration in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction显示文摘 | Wang NC Maggioni AP Konstam MA | 2008 | JAMA2008，99，22： | 1 |
| 14 | Randomized study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis 显示文摘 | MAGGIONI A BENEDETTI PP ANNA TD | 2006 | Br J Cancer2006，95，6： | 1 |
| 15 | Statins and symptomatic chronic systolic heart failure a post-hoc analysis of 5 010 patients enrolled in Val-HeFT显示文摘 | Krum H Latini R Maggioni AP | 2007 | Int J Cardiol2007，119，1： | 1 |
| 16 | Valsartan reduces the incidence of atrial fibrillation in patients with heart failure:results from the Valsartan Heart Failure Trial (Val-HeFT)显示文摘 | Maggioni AP Latini R Carson PE | 2005 | Am Heart J2005，149，： | 1 |
| 17 | Valsartan reduces the incidence of atrial fibrillation in patients with heart failure:results from valsartan heart failure trial(Val-HeFT) 显示文摘 | Maggioni AP Latini R Carson PE | 2005 | Am Heart J2005，149，： | 1 |
| 18 | Effects of rosuvastatin in patients with chronic heart failure:the GISSI-HF trial:a randomised,double-blind,placebo controlled trial显示文摘 | Gissi-HF Investigators Tavazzi L Maggioni AP | 2008 | Lancet2008，372，9645： | 1 |
| 19 | Blood levels of cytokines in elderly patients with major depressive disorder显示文摘 | Brambilla F Maggioni M | 1998 | Acta Psychiatr Scand1998，97，： | 1 |
| 20 | Age-re- lated increase in mortality among patients with first myo- cardial infarctiont reated with thrombolysis显示文摘 | MAGGIONI A P MASERI A FRESCO C | 1993 | N Engl J Med1993，329，： | 1 |
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