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| 1 | Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study显示文摘Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway,thus affecting the development of levodopa-induced dyskinesia in Parkinson’s disease(PD).In the present study,we analyzed whether the use of this class of medication was associated with a reduced occurrence of levodopa-induced dyskinesia,using electronically-stored information of idiopathic PD patients enrolled at Novara University Hospital“Maggiore della Carità”.We conducted a retrospective case-control study identifying PD patients with dyskinesias(PwD;n=47)as cases.For each PwD we selected a non-dyskinetic control(NoD),nearly perfectly matched according to sex,Unified Parkinson’s Disease Rating Scale(UPDRS)part III score,and duration of antiparkinsonian treatment.Binary logistic regression was used to evaluate whether dyskinesias were associated with ACEi/ARBs use.Ninety-four PD patients were included,aged 72.18±9 years,with an average disease duration of 10.20±4.8 years and 9.04±4.9 years of antiparkinsonian treatment.The mean UPDRS part III score was 18.87±7.6 and the median HY stage was 2.In the NoD group,25(53.2%)were users and 22(46.8%)non-users of ACEi/ARBs.Conversely,in the PwD group,11(23.4%)were users and 36 non-users(76.6%)of this drug class(Pearson chi-square=8.824,P=0.003).Concerning general medication,there were no other statistically significant differences between groups.After controlling for tremor dominant phenotype,levodopa equivalent daily dose,HY 3-4,and disease duration,ACEi/ARBs use was a significant predictor of a lower occurrence of dyskinesia(OR=0.226,95%CI:0.080-0.636,P=0.005).Therefore,our study suggests that ACEi/ARBs may reduce levodopa-induced dyskinesia occurrence and,thanks to good tolerability and easy management,represent a feasible choice when dealing with the treatment of hypertension in PD patients.The study was approved by the Ethics Committee of Novara University Hospital“Maggiore della Carità”(CE 65/16)on July 27,2016. | Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca Marino Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 2 | The Yin-Yang of osteopontin in nervous system diseases: damage versus repair显示文摘Osteopontin is a broadly expressed pleiotropic protein,and is attracting increased attention because of its role in the pathophysiology of several inflammatory,degenerative,autoimmune,and oncologic diseases.In fact,in the last decade,several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion,but also increasing their survival.The detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions(i.e.,multiple sclerosis,Parkinson’s,and Alzheimer’s diseases).Intriguingly,recent findings show that osteopontin is involved not only in promoting tissue damage(the Yin),but also in repair/regenerative mechanisms(the Yang),mostly triggered by the inflammatory response.These two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule,which are exposed after thrombin or metalloproteases cleavages.Such functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix interactions.This review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system diseases.Understanding the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein. | Giuseppe Cappellano Domizia Vecchio Luca Magistrelli Nausicaa Clemente Davide Raineri Camilla Barbero Mazzucca Eleonora Virgilio Umberto Dianzani Annalisa Chiocchetti Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，6： | 2 |
| 3 | A soluble form of CTLA--4 generated by alternative splicing is expressed by nonstimulated human T cells 显示文摘 | Magistrelli G Jeannin P Herbault N | 1999 | Eur J Immunol1999，29，11： | 1 |
| 4 | Pancreatic resection for periampullary cancer in elderly patients显示文摘 | Magistrelli P Masetti R Coppola R | 1988 | Hepatogastroenterology1988，45，19： | 1 |
| 5 | A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated humanT cells显示文摘 | Magistrelli G Jeannin P Herbault N etal | 1999 | Eur J Immunol1999，29，11： | 1 |
| 6 | Outer membrane protein A (OmpA) : a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies显示文摘 | Jeannin P Magistrelli G Goestsch L | 2002 | Vaccine2002，20，： | 1 |
| 7 | 显示文摘 | Jeannin P Magistrelli G Aubry JP | 2000 | Immunity2000，13，3： | 1 |
| 8 | Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma显示文摘 | Magistrelli P Coppola R Tonini G | 2006 | J Cell Biochem2006，97，1： | 1 |
| 9 | Diffusion-weighted imaging in breast lesion evaluation显示文摘 | P. Belli M. Costantini E. Bufi A. Magistrelli G. Torre L. Bonomo | 2010 | La radiologia medica2010，，1： | 1 |
| 10 | Detection of circulating soluble CD28 in patients with systemic lupus erythematosus,primary Sjogren's syndrome and systemic sclerosis显示文摘 | Hebbar M Jeannin P Magistrelli G | 2004 | Clin Exp Immunol2004，136，： | 1 |
| 11 | Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells-lmpact on vacine strategies显示文摘 | Jeannin P Magistrelli G Goetsch L | 2002 | Vaccine2002，20，4： | 1 |
| 12 | Paediatric tubercu- lar spinal abscess involving the dorsal, lumbar and sacral regions and causing spinal cord compression 显示文摘 | Bozzola E1 Bozzola M Magistrelli A | 2013 | Infez Med2013，21，3： | 1 |
| 13 | Outer membrane protein A (OmpA) : a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies显示文摘 | Pascale Jeannin Giovanni Magistrelli Liliane Goestsch | 2002 | Vaccine2002，204，： | 1 |
| 14 | A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells显示文摘 | Magistrelli G Jeannin P Herbault N | 1999 | Eur J Immunol1999，29，： | 1 |
| 15 | Combined modality therapy in low risk (T2N0) rectal cancer显示文摘 | Coco C Magistrelli P Netri G | 1995 | Rays1995，20，2： | 1 |
| 16 | Surgical treatment of metachronous rectal liver and lungmetastases: A combined videolaparoscopic andvideothoracoscopic approach显示文摘To the Editor:We read with tremendous interest the paper by Del Fabbro et al.[1].In this thorough article,the authors meticulously underline the advantages of a modified j-shaped incision for the simultaneous treatment of difficult liver colorectal metastases(CRM)and right-lung CRM,reporting their experience in a cohort of 11 patients.The thoracophrenolaparotomy described by Del Fabbro implicates the prolongation of the traditional j-shaped laparotomy along the 9th intercostal space,with the partial removal of the | francesco sucameli elisa francone laura dova prospero magistrelli emilio falco stefano berti | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 1 |
| 17 | Involvement of LOX-1 in dendritic cell-mediated antigen cress-presen- tation显示文摘 | Delneste Y Magistrelli G Gauchat J | 2002 | Immunity2002，17，3： | 1 |
| 18 | Outer membrane protein A (ompA):a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies显示文摘 | Jeannin P Magistrelli G Goetsch L | 2002 | Vaccine2002，20，1： | 1 |
| 19 | Conservative surgery for early cancer of the distal rectum显示文摘 | COco C Magistrelli P Granone P | 1992 | Dis Colon Rectum1992，35，2： | 1 |
| 20 | 显示文摘 | Jeannin P Magistrelli G Aubry JP | 2000 | Immunity2000，13，3： | 1 |
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