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| 1 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation. | Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy | 2017 | World Journal of Diabetes2017，8，2： | 8 |
| 2 | Assessment of nasal and paranasal sinus masses by diffusion-weighted MR imaging 显示文摘 | Razek AA Sieza S Maha B | 2009 | J Neuroradiol2009，36，： | 1 |
| 3 | A new approach to determine eddy current losses in the tank walls of a power transformer显示文摘 | Szabados B Mahas I EI SobkiM S EI | 1987 | IEEE Transactions on Power Delivery1987，2，3： | 1 |
| 4 | Antibiotic-associated bloody diarrhea in infants: clinical, endoscopic, and histopathologic profiles 显示文摘 | Maha B Zeinab E Mohamed M | 2011 | JPGN2011，52，1： | 1 |
| 5 | Effect of particle size、 chemical mechanical poishing slurries for enhanced polishing with minmial defects显示文摘 | Basmi G B Adler J J Maha jan U | | 0，，09： | 1 |
| 6 | Experimental investigation and computer simulation of thermal behaviour of wallboards containing a phase change material显示文摘 | MAHA A ANDR(E) B H(E)BERT S | 2006 | Energy and Buildings2006，38，4： | 1 |
| 7 | Co-dellvery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer 显示文摘 | MAHA S OLGA B G TAMARA M | 2008 | Nanomedicine2008，3，6： | 1 |
| 8 | Assessment of nasal and paranasal sinus masses by diffusion-weighted MR imaging显示文摘 | Razek A Sieza S Maha B | 2009 | J Neuroradiol2009，36，4： | 1 |
| 9 | Petri-net based formulation and algorithm for short-term scheduling of batch plants显示文摘 | Mahas G Parisa A B Peter L | 2005 | Computers and Chemical Engineering2005，29，： | 1 |
| 10 | Assessment of nasal and paranasal si- nus masses by diffusion-weighted MR imaging显示文摘 | Razek AA Sieza S Maha B | 2009 | J Neuroradiol2009，36，4： | 1 |
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