|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer,gastric carcinoma,and non-ulcer dyspepsia subjects with histological changes显示文摘AIM: To investigate the presence of the cay-pathogenicity island and the associated histological damage caused by strains with complete cay-PAI and with partial deletions in correlation to the disease status.METHODS: We analyzed the complete cag-PAI of 174representative Helicobacter pylori (H pylori ) clinical isolates obtained from patients with duodenal ulcer,gastric ulcer, gastric cancer, and non-ulcer dyspepsia using eight different oligonucleotide primers viz cagA1,cagA2, cagAP1, cagAP2, cagE, cagT, LEC-1, LEC-2spanning five different loci of the whole cag-PAI by polymerase chain reaction (PCR).RESULTS: The complete screening of the genes comprising the cag-PAI showed that larger proportions of subjects with gastric ulcer (97.8%) inhabited strains with complete cag-PAI, followed by gastric cancer (85.7%),non-ulcer dyspepsia (7.1%), and duodenal ulcer (6.9%),significant differences were found in the percentagedistribution of the genes in all the clinical groups studied.It was found that strains with complete cag-PAI were able to cause severe histological damage than with the partially deleted ones.CONCLUSION: The cay-PAI is a strong virulent marker in the disease pathogenesis as it is shown that a large number of those infected with strain with complete cag-PAI had one or the other of the irreversible gastric pathologies and interestingly 18.5% of them developed gastric carcinoma. The presence of an intact cayPAI correlates with the development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease. Partial deletions of the cag-PAI appear to be sufficient to render the organism less pathogenic. | Mahaboob Ali Aleem A Khan Santosh K Tiwari Niyaz Ahmed L Venkateswar Rao CM Habibullah | 2005 | World Journal of Gastroenterology2005，11，43： | 15 |
| 2 | Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice显示文摘Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in mice.Methods:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of acetaminophen.After 4 h,the mice were decapitated.Activities of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental mice.Results:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant status.Piperine and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant status.Conclusions:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin. | Evan Prince Sabina Annie Deborah Harris Souriyan Deborah Jackline Mahaboob Khan Rasool | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 7 |
| 3 | Studies on thermally grown oxide as an interface between plasma-sprayed coatings and a nickel-based superalloy substrate显示文摘A thermally grown oxide layer formed by hot corrosion was investigated as an interface between plasma-sprayed coatings and a nickel-based superalloy substrate. The hot corrosion mechanism of NiCr–Cr_2O_3 and Al_2O_3–40wt% TiO_2(A40T) plasma coated Inconel 617 was evaluated. The experiments were carried out at 1000°C using a combination of Na_2SO_4, NaCl, and V_2O_5 salts to simulate the conditions of a gas turbine in a marine environment. The hot corrosion results revealed the spallation and dissolution of oxides upon prolonged exposure. Optical images and scanning electron micrographs of the exposed samples revealed the formation of oxide scale and provided details of its morphology in NiCr–Cr_2O_3 coated samples. Microstructure characterization of A40T coatings demonstrated a thermally grown oxide(TGO) layer at 1000°C. Increasing the thickness of the TGO layer decreased the corrosion resistance. The elemental analysis and image mapping revealed the migration of active elements from the substrate and coatings toward the corrosive environment. | Adam Khan Mahaboob Basha Sundarrajan Srinivasan Natarajan Srinivasan | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，6： | 2 |
| 4 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | KHAN A A PARVEEN N MAHABOOB V S | 2008 | Transplantat Proc2008，40，4： | 1 |
| 5 | Safety and effica- cy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver fail- ure : a preliminary study 显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 6 | Safety and efficacyof autologous bone marrow stem cell transplantation throughhepatic artery for the treatment of chronic liver failure:a prelimi-nary study显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 7 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | KHAN AA PARVEEN N MAHABOOB VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 8 | Safety and effi- cacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure: a prelimina- ry study显示文摘 | KHAN AA PARVEEN N MAHABOOB VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 9 | Safety and efficacy of autologons bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | Khan AA Parveen N Mahaboob VS | | 0，，04： | 1 |
| 10 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure: a preliminary study 显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 11 | Management ofhyperbilirubinemia in biliary atresia by hepatic progenitor celltransplantation through hepatic artery: a case report 显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | TransplantProc2008，40，4： | 1 |
| 12 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure: a preliminary study显示文摘 | KHAN AA PARVEEN N MAHABOOB VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 13 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplantation Proceedings2008，，04： | 1 |
| 14 | Safety and Efficacy of Autologous Bone Marrow Stem Cell Transplantation Through Hepatic Artery for the Treatment of Chronic Liver Failure : A Preliminary Study 显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 15 | Fluoride Toxicity and Status of Serum Thyroid Hormones, Brain Histopathology, and Learning Memory in Rats: A Multigenerational Assessment显示文摘 | Piler Mahaboob Basha Puja Rai Shabana Begum | 2011 | Biological Trace Element Research2011，，1： | 1 |
| 16 | Safety and Efficacy of Autologous Bone Marrow Stem Cell Transplantation Through Hepatic Artery for the Treatment of Chronic Liver Failure: A Preliminary Study显示文摘 | A.A. Khan N. Parveen V.S. Mahaboob A. Rajendraprasad H.R. Ravindraprakash J. Venkateswarlu S.G.A. Rao M. Lakshmi Narusu M.N. Khaja R. Pramila A. Habeeb C.M. Habibullah | 2008 | Transplantation Proceedings2008，，4： | 1 |
| 17 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | KHAN AA PARVEEN N MAHABOOB VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 18 | Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplant Proc2008，40，4： | 1 |
| 19 | Safety and efficacy of autologous bone marow stem cell transplantation through hepat- ic artery for the treatment of chronic liver failure:a preliminary study显示文摘 | Khan AA Parveen N Mahaboob VS | 2008 | Transplant Proe2008，40，4： | 1 |
| 20 | Hepatoprotective and antioxidant effects of gallic acid in paracetamol‐induced liver damage in mice显示文摘 | Mahaboob KhanRasool Evan PrinceSabina Segu R.Ramya PranatharthiharanPreety SmitaPatel NiharikaMandal Punya P.Mishra JaisySamuel | 2010 | Journal of Pharmacy and Pharmacology2010，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员