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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Plant Small RNAs: Biogenesis, Mode of Action and Their Roles in Abiotic Stresses显示文摘Small RNAs (sRNAs) are 18-30 nt non-coding regulatory elements found in diverse organisms, which were initially identified as small double-stranded RNAs in Caenorhabditis elegans. With the development of new and improved technologies, sRNAs have also been identified and characterized in plant systems. Among them, micro RNAs (miRNAs) and small interfering RNAs (siRNAs) are found to be very important riboregulators in plants. Various types of sRNAs differ in their mode of biogenesis and in their function of gene regulation. sRNAs are involved in gene regulation at both transcriptional and post-transcriptional levels. They are known to regulate growth and development of plants. Furthermore, sRNAs especially plant miRNAs have been found to be involved in various stress responses, such as oxidative, mineral nutrient deficiency, dehydration, and even mechanical stimulus. Therefore, in the present review, we focus on the current understanding of biogenesis and regulatory mechanisms of plant sRNAs and their responses to various abiotic stresses. | Praveen Guleria Monika Mahajan Jyoti Bhardwaj Sudesh Kumar Yadav | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 10 |
| 3 | Interleukin-7 Receptor Signaling Network:An Integrated Systems Perspective显示文摘Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor,the IL-7 receptor (IL-7R),activates multiple pathways that regulate lymphocyte survival,glucose uptake,proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells,including the use of shared receptor components,signaling crosstalk,shared interaction domains,feedback loops,integrated gene regulation,multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology. | Megan J. Palmer Vinay S. Mahajan Lily C. Trajman Darrell J. Irvine Douglas A.Lauffenburger Jianzhu Chen | 2008 | Cellular & Molecular Immunology2008，5，2： | 8 |
| 4 | Psoas muscle metastasis from cervical carcinoma:Correlation and comparison of diagnostic features on FDG-PET/CT and diffusion-weighted MRI显示文摘Psoas muscle metastasis, though rare, is the commonest site of skeletal muscle involvement in cervical carcinoma. The appropriate clinical management of this condition, particularly of the pain related to malignant psoas syndrome, is still evolving and the diagnostic features on conventional morphological imaging modalities are often non specific, with the differential diagnosis lying between sarcoma, hematoma, and abscess. In this report, a comparison of various morphofunctional imaging modalities was made. Fluorodeoxyglucosepositron emission tomography(FDG-PET)/computed tomography(CT) was the first to suspect disease involvement of the psoas muscle, demonstrating intense FDG uptake(compared with the contralateral muscle), while ultrasound showed heterogeneous echotexture, and magnetic resonance imaging(MRI) showed subtle altered signal intensity in the right psoas muscle. Both anatomical imaging modalities and non contrast CT of the PET-CT examination demonstrated a bulky psoas muscle, without any focal abnormality. On diffusionweighted imaging of MRI(DWI-MRI), restricted diffusion of the involved muscle was an important observation. The psoas muscle metastatic involvement was proven histopathologically. Thus, enhanced glucose metabolism and restricted diffusion in the newer noninvasive molecular imaging modalities(e.g., PET/CT and DWI-MRI) could serve as valuable adjunctive parameters in diagnosing this entity in the absence of a focal abnormality in the anatomical modalities. In the treatment response monitoring scenario, FDG-PET/CT demonstrated near complete resolution following administration of 3 cycles of systemic chemotherapy and local external radiotherapy. | Sandip Basu Abhishek Mahajan | 2014 | World Journal of Radiology2014，6，4： | 6 |
| 5 | Clinical-radiological-pathological correlation of cavernous sinus hemangioma: Incremental value of diffusion-weighted imaging显示文摘AIM To elucidate the clinical, magnetic resonance imaging(MRI), pathological features of these lesions and asses the incremental value of diffusion-weighted imaging(DWI) in diagnosing them.METHODS Fifteen consecutive patients(11 females and 4 males; mean age 40.93 years; age range 13-63 years) with cavernous sinus hemangiomas(CSH) who underwent examination between November 2008 and May 2016 were included for the analysis. MRI, clinical and surgical findings of each patient was retrospectively reviewed. DWI were also analysed and mean-apparent diffusion coefficient(ADC) value was calculated. Eleven patients underwent surgical removal of the lesion and 2 patients had biopsy only. Diagnosis of CSH was confirmed histologically in 13 patients.RESULTS Eleven patients(73%) presented with headaches and 10(66%) had cranial nerve involvement. Extra cavernous sinus extension was noted in 14(94%). Surgery was performed in 13(87%) and post-operative radiation was given to 4(28%) patients. Thirteen patients remained asymptomatic on follow up. Three conspicuous imaging features were highly suggestive of the diagnosis: Lack of diffusion restriction(100%), homogeneous hyperintensity on T2 weighted image sequences(93.3%) and intense post-contrast enhancement(100%). The mean ADC was 1.82 × 10-3 ± 0.2186 cm2/s.CONCLUSION T1-weighted hypointensity with homogeneous hyperintensity on T2-weighted sequences, intense enhancement and absence of hemosiderin within the lesion on GRE sequence favour the diagnosis. Facilitated diffusion on DWI differentiates CSH from other solid cavernous sinus lesions and significantly improves the diagnostic accuracy, a critical factor for planning surgery. | Abhishek Mahajan Vedula Rajni Kanth Rao Gudipati Anantaram Ashwin M Polnaya Sandeep Desai Paresh Desai Rammohan Vadapalli Manas Panigrahi | 2017 | World Journal of Radiology2017，9，8： | 4 |
| 6 | 水刺非织造布的水刺工艺流程及其性能显示文摘非织造布需具备一定的初始强力以承受固结过程中受到由机械力、热和化学反应等引起的应力作用,最终得到所需强力。水刺工艺是通过一系列高速水针使纤维相互抱合缠结的技术。水刺法能够制备出具有特殊物理、力学和其他功能性的非织造布。综述了水刺法工艺参数设置对非织造布性能的影响,包括水针直径、水针间距、管压力及管数对非织造布结构和性能的影响。 | Sujit Gulhane Ranjit Turukmane Chetan Mahajan Mohit Joshi 童艺翾 | 2019 | 国际纺织导报2019，47，10： | 4 |
| 7 | Soil and water conservation measures improve soil carbon sequestration and soil quality under cashews显示文摘Land degradation is becoming a serious problem in the west coast region of India where one of the world's eight biodiversity hotspots,the‘Western Ghats’,is present.Poor land management practices and high rainfall have led to increasing problems associated with land degradation.A long-term(13-year)experiment was done to evaluate the impact of soil and water conservation measures on soil carbon sequestration and soil quality at three different depths under cashew nut cultivation on a 19%slope.Five soil and water conservation measures-continuous contour trenches,staggered contour trenches,halfmoon terraces,semi-elliptical trenches,and graded trenches all with vegetative barriers of Stylosanthes scabra and Vetiveria zizanoides and control were evaluated for their influence on soil properties,carbon sequestration,and soil quality under cashews.The soil and water conservation measures improved significantly the soil organic carbon,soil organic carbon stock,carbon sequestration rate and microbial activity compared to the control condition(without any measures).Among the measures tested,continuous contour trenches with vegetative barriers outperformed the others with respect to soil organic carbon stock,sequestration rate,and microbial activity.The lower metabolic quotient with the measures compared to the control indicated alleviation of environmental stress on microbes.Using principal component analysis and a correlation matrix,a minimum dataset was identified as the soil available nitrogen,bulk density,basal soil respiration,soil pH,acid phosphatase activity,and soil available boron and these were the most important soil properties controlling the soil quality.Four soil quality indices using two summation methods(additive and weighted)and two scoring methods(linear and non-linear)were developed using the minimum dataset.A linear weighted soil quality index was able to statistically differentiate the effect of soil and water conservation measures from that of the control.The highest value of the soil quality index of 0.98 was achieved with continuous contour trenches with a vegetative barrier.The results of the study indicate that soil and water conservation measures for cashews are a potential strategy to improve the soil carbon sequestration and soil quality along with improving crop productivity and reducing the erosion losses. | Gopal Ramdas Mahajan Bappa Das Sandrasekaran Manivannan Begur Lakshminarasimha Manjunath Ram Ratan Verma Sujeet Desai Rahul Mukund Kulkarni Ashish Marotrao Latare Reshma Sale Dayesh Murgaonkar Kiran Puna Patel Shaiesh Morajkar Ashwini Desai Natasha Barnes Heena Mulla | 2021 | International Journal of Sediment Research2021，36，2： | 4 |
| 8 | Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”显示文摘'Personalized oncology' is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of 'radiomics/radiogenomics'. Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that 'one size fits all'. It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in 'personalized oncology'. | Abhishek Mahajan Sneha S Deshpande Meenakshi H Thakur | 2017 | World Journal of Radiology2017，9，6： | 3 |
| 9 | Agricultural waste material as potential adsorbent for sequestering heavy metal ions from aqueous solutions – A review显示文摘 | Dhiraj Sud Garima Mahajan M.P. Kaur | 2007 | Bioresource Technology2007，，14： | 3 |
| 10 | Modified Atmosphere Packaging Technology of Fresh and Fresh-cut Produce and the Microbial Consequences—A Review显示文摘 | Oluwafemi J. Caleb Pramod V. Mahajan Fahad Al-Julanda Al-Said Umezuruike Linus Opara | 2013 | Food and Bioprocess Technology2013，，2： | 3 |
| 11 | Review of current progress in hole-transporting materials for perovskite solar cells显示文摘Recent advancements in perovskites’ application as a solar energy harvester have been astonishing. The power conversion efficiency(PCE) of perovskite solar cells(PSCs) is currently reaching parity(>25 percent), an accomplishment attained over past decades. PSCs are seen as perovskites sandwiched between an electron transporting material(ETM) and a hole transporting material(HTM). As a primary component of PSCs, HTM has been shown to have a considerable effect on solar energy harvesting, carrier extraction and transport, crystallization of perovskite, stability, and price. In PSCs, it is still necessary to use a HTM.While perovskites are capable of conducting holes, they are present in trace amounts, necessitating the use of an HTM layer for efficient charge extraction. In this review, we provide an understanding of the significant forms of HTM accessible(inorganic, polymeric and small molecule-based HTMs), to motivate further research and development of such materials. The identification of additional criteria suggests a significant challenge to high stability and affordability in PSC. | Prerna Mahajan Bhavya Padha Sonali Verma Vinay Gupta Ram Datt Wing Chung Tsoi Soumitra Satapathi Sandeep Arya | 2022 | Journal of Energy Chemistry2022，31，5： | 3 |
| 12 | Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status显示文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC. | James Wei Tatt Toh Angela L Ferguson Kevin J Spring Hema Mahajan Umaimainthan Palendira | 2021 | World Journal of Clinical Oncology2021，12，4： | 2 |
| 13 | Cold, salinity and drought stresses: An overview显示文摘 | Shilpi Mahajan Narendra Tuteja | 2005 | Archives of Biochemistry and Biophysics2005，，2： | 2 |
| 14 | Lymphocytic Colitis and Collagenous Colitis: A Review of Clinicopathologic Features and Immunologic Abnormalities显示文摘 | Dipti Mahajan John R. Goldblum Shu-Yuan Xiao Bo Shen Xiuli Liu | 2012 | Advances In Anatomic Pathology2012，，1： | 2 |
| 15 | Automated Identification Algorithm Using CNN for Computer Vision in Smart Refrigerators显示文摘Machine Learning has evolved with a variety of algorithms to enable state-of-the-art computer vision applications.In particular the need for automating the process of real-time food item identification,there is a huge surge of research so as to make smarter refrigerators.According to a survey by the Food and Agriculture Organization of the United Nations(FAO),it has been found that 1.3 billion tons of food is wasted by consumers around the world due to either food spoilage or expiry and a large amount of food is wasted from homes and restaurants itself.Smart refrigerators have been very successful in playing a pivotal role in mitigating this problem of food wastage.But a major issue is the high cost of available smart refrigerators and the lack of accurate design algorithms which can help achieve computer vision in any ordinary refrigerator.To address these issues,this work proposes an automated identification algorithm for computer vision in smart refrigerators using InceptionV3 and MobileNet Convolutional Neural Network(CNN)architectures.The designed module and algorithm have been elaborated in detail and are considerably evaluated for its accuracy using test images on standard fruits and vegetable datasets.A total of eight test cases are considered with accuracy and training time as the performance metric.In the end,real-time testing results are also presented which validates the system’s performance. | Pulkit Jain Paras Chawla Mehedi Masud Shubham Mahajan Amit Kant Pandit | 2022 | Computers, Materials & Continua2022，，5： | 2 |
| 16 | Total Laparoscopic Hysterectomy with Earlier Uterine Artery Ligation显示文摘 | Rakesh Sinha Meenakshi Sundaram Yogesh A. Nikam Aparna Hegde Chaitali Mahajan | 2008 | The Journal of Minimally Invasive Gynecology2008，，： | 2 |
| 17 | Aerosol printing and photonic sintering of bioresorbable zinc nanoparticle ink for transient electronics manufacturing显示文摘Bioresorbable electronics technology can potentially lead to revolutionary applications in healthcare, consumer electronics, and data security. This technology has been demonstrated by various functional devices. However, majority of these devices are realized by CMOS fabrication approaches involving complex and time-consuming processes that are high in cost and low in yield. Printing electronics technology represents a series of printing and post processing techniques that hold promise to make high performance bioresorbable electronics devices. But investigation of printing approaches for bioresorbable electronics is very limited. Here we demonstrate fabrication of conductive bioresorbable patterns using aerosol printing and photonic sintering approaches. Experimental results and simulation reveals that ink compositions, photonic energy, film thickness, and ventilation conditions may influence the effect of photonic sintering. A maximum conductivity of 22321.3 S/m can be achieved using 1 flash with energy of 25.88 J/cm^2 with duration of 2 ms. By combining two cascaded sintering procedures using flash light and laser further improve the conductivity to 34722.2 S/m. The results indicate that aerosol printing and photonic sintering can potentially yield mass fabrication of bioresorbable electronics, leading to prevalence of printable bioresorbable technology in consumer electronics and biomedical devices. | Bikram Kishore MAHAJAN BrANDon LUDWIG Wan SHOU Xiaowei YU Emmanuel FREGENE Hang XU Heng PAN Xian HUANG | 2018 | Science China(Information Sciences)2018，61，6： | 2 |
| 18 | Consumer switching costs: A typology, antecedents, and consequences显示文摘 | Thomas A. Burnham Judy K. Frels Vijay Mahajan | 2003 | Journal of the Academy of Marketing Science2003，，2： | 2 |
| 19 | Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease显示文摘 | Brian A. Ference Wonsuk Yoo Issa Alesh Nitin Mahajan Karolina K. Mirowska Abhishek Mewada Joel Kahn Luis Afonso Kim Allan Williams John M. Flack | 2012 | Journal of the American College of Cardiology2012，，25： | 2 |
| 20 | Synthesis of RE(OH)_2Cl and REOCl (RE=Eu, Tb) nanostructures显示文摘Anisotropic structures, nanoneedles, and nanospindles of rare earth hydroxychloride (RE(OH)2Cl) and oxychloride (REOCl) (rare earth=Eu and Tb) were synthesized. The rare earth hydroxychloride nanostructures were formed via a thermally assisted hydrolysis of the rare-earth sesquioxide nanocrystals. The morphological evolution of the nanostructures was studied using high-resolution transmission elec- tron microscopy and scanning electron microscopy, while the structural evolution was investigated using X-ray diffraction techniques. The thermal stability of the rare earth hydroxychlorides was investigated using thermogravimetric analysis. The rare earth oxychloride nanospin- dles were synthesized via a simple heat-treatment of rare earth hydroxychloride nanospindles. | S. V. Mahajan J. Hart J. Hood A. Everheart M. L. Redigolo D. S. Koktysh E. A. Payzant J. H. Dickerson | 2008 | Journal of Rare Earths2008，26，2： | 2 |
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